Hsiao-hua Yu

Organic and Polymer Materials, Nanobiotechnology, Cell Materials Interface

Hsiao-hua Yu (尤嘯華)

Associate Research Fellow (2014-);B.S., Department of Chemistry, National Taiwan University (1992-1996);Teaching assistant, Department of Chemistry, National Taiwan University (1996-1997); Ph.D., Department of Chemistry, Massachusetts Institute of Technology (1997-2003);Postdoctoral Researcher, Department of Chemical Engineering, Massachusetts Institute of Technology (2003-2004);Senior Research Scientist, Institute of Bioengineering and Nanotechnology, Singapore (2004-2008); Initiative Research Scientist, RIKEN, Japan(2008-2013);Associate Chief Scientist, RIKEN, Japan(2013-2014); Visiting Undergraduate Researcher, The Scripps research Institute (1995);Adjunct Assistant Professor, Division of Materials Technology, School of Materials Science and Engineering, Nanyang Technological University, Singapore (2008);Adjunct Associate Professor, Department of Electronic Chemistry, Interdisciplinary Graduate School of Science and Technology, Tokyo Institute of Technology, Japan (2010-2014);Academic Year 2nd Term Young Scholar Abroad Oustanding Scholarship from Foundation For The Advancement of Oustanding Scholarship(2013);
Research Interests

Design molecular architecture toward target functions and utilize green and efficient approaches to synthesize these molecules.
Control the nanostructure assembly for formation of nanomaterials and add in additional property-control components to derive desired properties.
Demonstrate the target functions (biomedical applications, energy, catalysis) and direct the materials for real applications.

Selected Publications
  1. Lin, H.-A.; Luo, S.-C.; Zhu, B.; Chen, C.; Yamashita, Y.; Yu, H.-h. Molecular structures or nano-assemblies? the deciding factor of surface properties in poly(3,4-ethylenedioxythiophene) nanorod array. Adv. Funct. Mater. 2013, 23, 3212.
  2. Hou, S.; Zhao, H.; Zhao, L.; Shen, Q.; Wei, K. S.; Suh D. Y.; Nakao, A.; Xiong B.; Luo, S.-C.; Tseng, H.-R.; Yu, H.-h. Capture and stimulated release of circulating tumor cells on polymer grafted silicon nanostructures. Adv. Mater. 2013, 25, 1547. (Press coverage by National Cancer Institute, Nanowerk.com, Sciencedaily.con, Nikkan Kogyo Shimbun, Nihon Keizai Shimbun, Yahoo Japan News, etc. RIKEN Research "Highlight of the Month". Selected as inside cover for Advanced Materials)
  3. Zhao, H.; Liu, C.-H.; Luo, S.-C.; Zhu, B.; Wang, T.-H.; Hsu, H.-F.; Yu, H.-h. Facile syntheses of dioxythiophene-based conjugated polymers by direct C-H arylation. Macromolecules 2012, 45, 7783.
  4. Luo, S.-C.; Zhu, B.; Kantchev, E. A. B.; Zhu, B.; Siang, Y. W.; Yu, H.-h. Tunable, dynamic and electrically stimulated lectin-carbohydrate recognition on a glycan-grafted conjugated polymer. Chem. Commun. 2012, 48, 6942.
  5. Sekine, J.; Luo, S.-C.; Wang, S.; Zhu, B.; Tseng, H.R.; Yu, H.-h. Functionalized conducting polymer nanodots for enhanced cell capturing: the synergistic effect of capture agents and nanostructures. Adv. Mater. 2011, 23, 4788. (Highlighted by RIKEN Research)
  6. Liu, C.-Y.; Zhao, H.; Yu, H.-h. Efficient synthesis of 3,4-Ethylenedioxythiophene (EDOT)-based functional π-conjugated molecules through direct C-H bond arylations. Org. Lett. 2011, 13, 4068.
  7. Luo, S.-C.; Zhu, B.; Nakao, A.; Nakatomi, R.; Yu, H.-h. Functionalized conducting polymer nano-networks from controlled oxidation polymerization toward cell engineering. Adv. Eng. Mater. (Advanced Biomaterials) 2011, 13, B423. (Invited article by E-MRS 2010 Spring Meeting. Selected as section cover for Advanced Biomaterials)
  8. Luo, S.-C.; Liour, S. S.; Yu, H.-h. Perfluoro-functionalized PEDOT films with controlled morphology as superhydrophobic coatings and biointerfaces with enhanced cell adhesion. Chem. Commun. 2010, 46, 4731.
  9. Luo, S.-C.; Mohamed Ali, E.; Tansil, N. C.; Yu, H.-h.; S. Gao, Kantchev, E. A. B.; Ying, J. Y. PEDOT nanobiointerfaces: thin, ultrasmooth, and functionalized poly(3,4-ethylenedioxythiophene) films with in vitro and in vivo biocompatibility. Langmuir 2008, 24, 8071.

Update: 2015-03-23

Journal Paper
  1. Xiaomeng Liu, Tongfang Xiao, Fei Wu, Mo-Yuan Shen, Meining Zhang*, Hsiao-hua Yu*, Lanqun Mao* Ultrathin Cell-Membrane-Mimic Phosphorylcholine Polymer Film Coating Enables Large Improvements for In Vivo Electrochemical Detection. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2017-08-0356, 11802-11806.
  2. Shuang Hou, Jie-Fu Chen, Min Song, Yazhen Zhu, Yu Jen Jan, Szu Hao Chen, Tzu-Hua Weng, Dean-An Ling, Shang-Fu Chen, Tracy Ro, An-Jou Liang, Tom Lee, Helen Jin, Man Li, Lian Liu, Yu-Sheng Hsiao, Peilin Chen, Hsiao-Hua Yu, Ming-Song Tsai*, 
Margareta D. Pisarska*, Angela Chen*, Li-Ching Chen*, Hsian-Rong Tseng* Imprinted NanoVelcro Microchips for Isolation and Characterization of Circulating Fetal Trophoblasts: Toward Noninvasive Prenatal Diagnostics. ACS NANO 2017-07-1911, 8167-8177.
  3. Zha Li, Pan He, Hui Chong, Akihiro Furube, Kazuhiko Seki, Hsiao-hua Yu, Keisuke Tajima, Yoshihiro Ito*, Masuki Kawamoto* Direct Aqueous Dispersion of Carbon Nanotubes Using Nanoparticle-Formed Fullerenes and Self-Assembled Formation of p/n Heterojunctions with Polythiophene. ACS Omega 20172(4), 1625-1632.
  4. Jin-sil Choi, Yazhen Zhu, Hongsheng Li, Parham Peyda, Thuy Tien Nguyen, Mo Yuan Shen, Yang Michael Yang, Jingyi Zhu, Mei Liu, Mandy M. Lee, Shih-Sheng Sun, Yang Yang, Hsiao-hua Yu, Kai Chen*, Gary S. Chuang*, and Hsian-Rong Tseng* Cross-Linked Fluorescent Supramolecular Nanoparticles as Finite Tattoo Pigments with Controllable Intradermal Retention Times. ACS NANO 2016-11-3011, 153-162.
  5. Pan He, Kyoji Hagiwara, Hui Chong, Hsiao-hua Yu*, Yoshihiro Ito* Low-Molecular-Weight Polyethyleneimine Grafted Polythiophene for Efficient siRNA Delivery. BIOMED RESEARCH INTERNATIONAL 2015-06, Article ID 406389.
  6. Ching-Yuan Liu , Hui Chong , Hsing-An Lin , Yoshiro Yamashita , Bin Zheng , Kuo-Wei Huang , Daisuke hashizume and Hsiao-hua Yu* Palladium-Catalyzed Direct C-H Arylations of Dioxythiophenes Bearing Reactive Functional Groups: A Step-Economical Approach for Functional π-Conjugated Oligoarenes. ORGANIC & BIOMOLECULAR CHEMISTRY 2015-0613, 8505-8511.
  7. Hui Chong, Hsing-An Lin, Mo-Yuan Shen, Ching-Yuan Liu, Haichao Zhao, and Hsiao-hua Yu* Step-Economical Syntheses of Functional BODIPY-EDOT π-Conjugated Materials through Direct C–H Arylation. ORGANIC LETTERS 2015-0617 (13), 3198-3201.
  8. Yu-Sheng Hsiao*, Bo-Cheng Ho, Hong-Xin Yan, Chiung-Wen Kuo, Di-Yen Chueh, Hsiao-hua Yu and Peilin Chen* Integrated 3D conducting polymer-based bioelectronics for capture and release of circulating tumor cells. JOURNAL OF MATERIALS CHEMISTRY B 2015-053, 5103-5110.
  9. Zunfu Ke*, Millicent Lin, Jie-Fu Chen, Jin-sil Choi, Yang Zhang, Anna Fong, An-Jou Liang, Shang-Fu Chen, Qingyu Li, Wenfeng Fang, Pingshan Zhang, Mitch A. Garcia, Tom Lee, Min Song, Hsing-An Lin, Haichao Zhao, Shyh-Chyang Luo, Shuang Hou*, Hsiao-hua Yu*, Hsian-Rong Tseng* Programming Thermoresponsiveness of NanoVelcro Substrates Enables Effective Purification of Circulating Tumor Cells in Lung Cancer Patients. ACS Nano 2015-019(1), 62-70.
  10. Jae-Eun Lee, Shyh-Chyang Luo, Bo Zhu, Joon Won Park*, Hsiao-hua Yu* Nanoscale analysis of functionalized polythiophene surfaces: the effects of electropolymerization methods and thermal treatment. RSC Advances 2014-114, 62666-62672.
  11. Bo Zhu, Shyh-Chyang Luo, Haichao Zhao, Hsing-An Lin, Jun Sekine, Aiko Nakao, Chi Chen, Yoshiro Yamashita, Hsiao-hua Yu* Large enhancement in neurite outgrowth on a cell membrane-mimicking conducting polymer. Nature Communications 2014-075 , 4523.
  12. Jae-Eun Lee, Ju-Won Kwak, Joon Won Park, Shyh-Chyang Luo, Bo Zhu, Hsiao-hua Yu* Nanoscale Analysis of a Functionalized Polythiophene Surface by Adhesion Mapping. ANALYTICAL CHEMISTRY 2014-0686, 6865−6871.
  13. Bor-Ran Li, Mo-Yuan Shen, Hsiao-hua Yu, Yaw-Kuen Li* Rapid construction of an effective antifouling layer on a Au surface via electrodeposition. CHEMICAL COMMUNICATIONS 2014-0550, 6793-6796.
  14. Yu-Sheng Hsiao*, Shyh-Chyang Luo, Shuang Hou, Bo Zhu, Jun S ekine, Chiung-Wen Kuo, Di-Yen Chueh, Hsiao-hua Yu*, Hsian-Rong Tseng*, Peilin Chen* 3D Bioelectronic Interface: Capturing Circulating Tumor Cells onto Conducting Polymer-Based Micro/Nanorod Arrays with Chemical and Topographical Control. SMALL 2014-0410(15), 3012–3017.
  15. Zha Li, Takanori Uzawa, Haichao Zhao, Shyh-Chyang Luo, Hsiao-hua Yu, Eiry Kobatake, Yoshihiro Ito* In vitro selection of peptide aptamers using a ribosome display for a conducting polymer. JOURNAL OF BIOSCIENCE AND BIOENGINEERING 2014117(4), 501-503.