Chang, Chi-Kwong

Inorganic Chemistry

Chang, Chi-Kwong (張啟光)

B.S, 1969, Fu Jen Catholic University (Taiwan); Ph.D., 1973, University of California-San Diego. Postdoctoral, University of California-San Diego. Postdoctoral,University of British Columbia;Professor, Department of Chemistry, Michigan State University; Professor, Head, 1998-2004, Department of Chemistry, The Hong Kong University of Science & Technology; Distinguished Chair Professor, 2009-2014, National Taiwan University;Alfred P. Sloan Fellow, 1980-1982; Camille and Henry Dreyfus Teacher-Scholar Award, 1981-1985; Distinguished Faculty Award, Michigan State University, 1991.;
Research Interests

Porphyrins and Porphyrinoidal Ligands
Biological Oxygen Binding and Activation
Metalloenzymes Models
Monooxygenation Catalysis
Photodynamic Therapy using Porphyrin Tumorcidal Agents

Selected Publications
  1. Chang, C. K. Paul Rothemund and S. Ferguson MacDonald, and their Namesake Reactions - the Influence of the Fischer School on my Life in Porphyrin Chemistry. Israel J. Chem. 2015, 55, DOI: 10.1002/ijch.201500043.
  2. Zoi, H.-B.; Yang, H.; Liu, Z.-Y.; Mahmood, M. H. R.; Mei, G.-Q.; Liu, H.-Y; Chang, C. K. Iron(IV)-Corrole Catalyzed Stereoselective Olefination of Aldehydes with Ethyl Diazoacetate. Organometallics 2015, 34, 2791
  3. Nga, N.-C.; Mahmood, M. H. R.; Liu, H. Y.; Yam, F.; Yeung, L.-L.; Chang, C. K. Appended corrole manganese complexes: Catalysis and axial-ligand effect. Chin. Chem. Lett. 2014, 25, 571-574.
  4. Liu, H. Y.; Mahmood, M. H. R.; Qiu, S.-X.; Chang, C.-K. Recent Developments in Manganese Corrole Chemistry. Coord. Chem. Rev. 2013, 257, 1306.
  5. Mahmood, M. H. R.; Liu, H. Y.; Wang, H. H.; Jiang, Y. Y.; Chang, C.- K. Unexpected One-Pot Synthesis of A3-Type Unsymmetrical Porphyrin. Tetrahedron Lett. 2013, 54, 5853.
  6. Ying, X.; Long, X. Y.; Mahmood, M. H. R.; Hu, Q. Y.; Liu, H. Y.; Chang, C.-K. Second-Order Nonlinear Optical Properties of Corroles: Experimental and Theoretical Investigations. Porphyrins Phthalocyanines 2012, 16, 1276.
  7. Xing, B.; Jiang, T.; Bi, W.; Yang, Y.; Li, L.; Ma, M.; Chang, C.-K.; Xu, B.; Yeow, E. K. L. Multifunctional Divalent Vancomycin: the Fluorescent Imaging and Photodynamic Antimicrobial Properties for Drug Resistant Bacteria. Chem. Commun. 2011, 47(5), 1601.
  8. Lu, J.; Liu, H. Y.; Shi, L.; Wang, X. L.; Ying, X.; Zhang, L.; Ji, L. N.; Zang, L. Q.; Chang, C.-K. DNA Cleavage Mediated by Water-Soluble Manganese Corrole. Chin. Chem. Lett. 2011, 22(1), 101.
  9. Koon, H. K.; Chan, P. S.; Wu, Z. G.; Wong, R. N. S.; Lung, M. L.; Chang, C.-K.; Mak, N. K. Role of Mitogen-Activated Protein Kinase in Zn-Bc-Am Pdt-Induced Apoptosis in Nasopharyngeal Carcinoma Cells. Cell Biochem. Funct. 2010, 28(3), 239.
  10. Koon, H.-K.; Lo, K.-W.; Leung, K.-N.; Lung, M. L.; Chang, C. C.-K.; Wong, R. N.-S.; Leung, W.-N.; Mak, N.-K. Photodynamic Therapy-Mediated Modulation of Inflammatory Cytokine Production by Epstein-Barr Virus-Infected Nasopharyngeal Carcinoma Cells. Cell. Mol. Immunol. 2010, 7(4), 323.
  11. Shi, L.; Liu, H.-Y.; Shen, H.; Hu, J.; Zhang, G.-L.; Wang, H.; Ji, L. N.; Chang, C.-K.; Jiang, H.-F. Fluorescence Properties of Halogenated Mono-Hydroxyl Corroles: The Heavy-Atom Effects. J. Porphyrins Phthalocyanines 2009, 13(12), 1221.
  12. Liu, H.-Y.; Yam, F.; Xie, Y.-T.; Li, X.-Y; Chang, C.-K. A Bulky Bis-pocket Manganese (V)-Oxo Corrole Complex: Observation of Oxygen Atom Transfer between Triply Bonded MnVO and Alkene. J. Am. Chem. Soc. 2009131, 12890.
  13. Wang, Q.; Yang, Z.; Ma, M.; Chang, C.-K.; Xu, B. High Catalytic Activities of Artificial Peroxidases Based on Supramolecular Hydrogels that Contain Heme Models. Chem. Eur. J. 200814, 5073.
  14. Liu, H.-Y.; Lai, T.-S.; Yeung, L.-L.; Chang, C.-K. First Synthesis of Perfluorinated Corrole and Its Mn=O Complex. Org. Lett. 20035, 617.
  15. Deng, Y.; Chang, C.-K.; Nocera, D. Facile Synthesis ofβ-Derivatized Porphyrins-Structural Characterization of aβ-β-Bis-Porphyrin. Angew. Chem. Int. Ed. Engle. 200039, 1066.
  16. Kessel, D.; Luo, Y.; Deng, Y.; Chang, C.-K. The Role of Sub-cellular Localization in Initiation of Apoptosis by Photodynamic Therapy. Photochem. Photobiol. 199765, 422.
  17. Liang, Y.; Chang, C.-K.; Peng, S.-M. Molecular Recognition with C-Clamp Porphyrins: Synthesis, Structural, and Complexation Studies. J. Mol. Recogn. 19969, 149.
  18. Chang, C.-K.; Liang, Y.; Aviles, G.; Peng, S.-M. Conformational Control of Intramolecular H-Bonding in Heme Models: Maximal Co(II)-O2Binding in a C-Clamp Porphyrin. J. Am. Chem. Soc. 1995117, 4191.
  19. Chang, C.-K.; Aviles, G.; Bag, N. Verdoheme-like Oxaporphyrin Formation by Oxygenation of a Co(II) Porphyrinyl Naphthoic Acid. A New Model of Heme Degradation. J. Am. Chem. Soc. 1994116, 12127.

Update: 2016-01-06