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張啟光 (Chi-Kwong Chang)

無機化學

張啟光 (Chi-Kwong Chang)

    886-2-55728668
    886-2-27831237
    changc*
特聘講座(103年-);臺灣大學特聘講座教授(98-103年);香港科技大學化學系教授、系主任(87-93年); 輔仁大學化學系學士(58年);美國加州大學聖地牙哥分校博士(62年);美國加州大學聖地牙哥分校、英屬哥倫比亞大學博士後研究;密西根州立大學化學系教授;Alfred P. Sloan Fellow(69-71年); Camille and Henry Dreyfus Teacher-Scholar Award(70-74年);Michigan State University Distinguished Faculty Award(80年);
研究領域

紫質及其金屬錯合物(合成、化性、催化、光譜等)
紫質衍生物應用在光動力效應治療癌腫瘤

研究圖片1

代表作
  1. Chang, C. K. Paul Rothemund and S. Ferguson MacDonald, and their Namesake Reactions - the Influence of the Fischer School on my Life in Porphyrin Chemistry. Israel J. Chem. 2015, 55, DOI: 10.1002/ijch.201500043.
  2. Zoi, H.-B.; Yang, H.; Liu, Z.-Y.; Mahmood, M. H. R.; Mei, G.-Q.; Liu, H.-Y; Chang, C. K. Iron(IV)-Corrole Catalyzed Stereoselective Olefination of Aldehydes with Ethyl Diazoacetate. Organometallics 2015, 34, 2791
  3. Nga, N.-C.; Mahmood, M. H. R.; Liu, H. Y.; Yam, F.; Yeung, L.-L.; Chang, C. K. Appended corrole manganese complexes: Catalysis and axial-ligand effect. Chin. Chem. Lett. 2014, 25, 571-574.
  4. Liu, H. Y.; Mahmood, M. H. R.; Qiu, S.-X.; Chang, C.-K. Recent Developments in Manganese Corrole Chemistry. Coord. Chem. Rev. 2013, 257, 1306.
  5. Mahmood, M. H. R.; Liu, H. Y.; Wang, H. H.; Jiang, Y. Y.; Chang, C.- K. Unexpected One-Pot Synthesis of A3-Type Unsymmetrical Porphyrin. Tetrahedron Lett. 2013, 54, 5853.
  6. Ying, X.; Long, X. Y.; Mahmood, M. H. R.; Hu, Q. Y.; Liu, H. Y.; Chang, C.-K. Second-Order Nonlinear Optical Properties of Corroles: Experimental and Theoretical Investigations. Porphyrins Phthalocyanines 2012, 16, 1276.
  7. Xing, B.; Jiang, T.; Bi, W.; Yang, Y.; Li, L.; Ma, M.; Chang, C.-K.; Xu, B.; Yeow, E. K. L. Multifunctional Divalent Vancomycin: the Fluorescent Imaging and Photodynamic Antimicrobial Properties for Drug Resistant Bacteria. Chem. Commun. 2011, 47(5), 1601.
  8. Lu, J.; Liu, H. Y.; Shi, L.; Wang, X. L.; Ying, X.; Zhang, L.; Ji, L. N.; Zang, L. Q.; Chang, C.-K. DNA Cleavage Mediated by Water-Soluble Manganese Corrole. Chin. Chem. Lett. 2011, 22(1), 101.
  9. Koon, H. K.; Chan, P. S.; Wu, Z. G.; Wong, R. N. S.; Lung, M. L.; Chang, C.-K.; Mak, N. K. Role of Mitogen-Activated Protein Kinase in Zn-Bc-Am Pdt-Induced Apoptosis in Nasopharyngeal Carcinoma Cells. Cell Biochem. Funct. 2010, 28(3), 239.
  10. Koon, H.-K.; Lo, K.-W.; Leung, K.-N.; Lung, M. L.; Chang, C. C.-K.; Wong, R. N.-S.; Leung, W.-N.; Mak, N.-K. Photodynamic Therapy-Mediated Modulation of Inflammatory Cytokine Production by Epstein-Barr Virus-Infected Nasopharyngeal Carcinoma Cells. Cell. Mol. Immunol. 2010, 7(4), 323.
  11. Shi, L.; Liu, H.-Y.; Shen, H.; Hu, J.; Zhang, G.-L.; Wang, H.; Ji, L. N.; Chang, C.-K.; Jiang, H.-F. Fluorescence Properties of Halogenated Mono-Hydroxyl Corroles: The Heavy-Atom Effects. J. Porphyrins Phthalocyanines 2009, 13(12), 1221.
  12. Liu, H.-Y.; Yam, F.; Xie, Y.-T.; Li, X.-Y; Chang, C.-K. A Bulky Bis-pocket Manganese (V)-Oxo Corrole Complex: Observation of Oxygen Atom Transfer between Triply Bonded MnVO and Alkene. J. Am. Chem. Soc. 2009131, 12890.
  13. Wang, Q.; Yang, Z.; Ma, M.; Chang, C.-K.; Xu, B. High Catalytic Activities of Artificial Peroxidases Based on Supramolecular Hydrogels that Contain Heme Models. Chem. Eur. J. 200814, 5073.
  14. Liu, H.-Y.; Lai, T.-S.; Yeung, L.-L.; Chang, C.-K. First Synthesis of Perfluorinated Corrole and Its Mn=O Complex. Org. Lett. 20035, 617.
  15. Deng, Y.; Chang, C.-K.; Nocera, D. Facile Synthesis ofβ-Derivatized Porphyrins-Structural Characterization of aβ-β-Bis-Porphyrin. Angew. Chem. Int. Ed. Engle. 200039, 1066.
  16. Kessel, D.; Luo, Y.; Deng, Y.; Chang, C.-K. The Role of Sub-cellular Localization in Initiation of Apoptosis by Photodynamic Therapy. Photochem. Photobiol. 199765, 422.
  17. Liang, Y.; Chang, C.-K.; Peng, S.-M. Molecular Recognition with C-Clamp Porphyrins: Synthesis, Structural, and Complexation Studies. J. Mol. Recogn. 19969, 149.
  18. Chang, C.-K.; Liang, Y.; Aviles, G.; Peng, S.-M. Conformational Control of Intramolecular H-Bonding in Heme Models: Maximal Co(II)-O2Binding in a C-Clamp Porphyrin. J. Am. Chem. Soc. 1995117, 4191.
  19. Chang, C.-K.; Aviles, G.; Bag, N. Verdoheme-like Oxaporphyrin Formation by Oxygenation of a Co(II) Porphyrinyl Naphthoic Acid. A New Model of Heme Degradation. J. Am. Chem. Soc. 1994116, 12127.

Update: 2016-01-06