Hsiung-Lin Tu

表面物理及材料化學,化學與系統生物

涂熊林 (Hsiung-Lin Tu)

    886-2-27898622
    886-2-27831237
    hltu
    涂熊林 實驗室
加州柏克萊分校化學博士(97-102年);台灣大學化學碩士(92-94年);交通大學應用化學系學士(88-92车);芝加哥大學分子工程所博士後研究員(105-106年)(ETH實驗室搬遷);蘇黎世聯邦理工學院EMBO長期資助博士後研究員(103-105年);加州定量生物科學中心博士後研究員(102-103年);
代表作
  1. Christensen, S.*; Tu, H.-L.*; Jun, J.*; Alvarez, S.; Triplet, M.; Iwig, J.; Yadav, K.; Bar-Sagi, D.; Roose, J.; Groves, J. One-way membrane trafficking of SOS in receptor- triggered Ras activation. Nat. Struct. Mol. Biol. 2016, 23, 838. (*: equal contribution).
  2. Huang, W. Y.-C.; Yan, Q.; Lin, W.-C.; Chung, J.; Hansen, S.; Christensen, S.; Tu, H.-L.; Kuriyan, J.; Groves, J. Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS. Proc. Natl. Acad. Sci. 2016, 113, 8218.
  3. Christensen, S.; Triplet, M.; Rhodes, C.; Iwig, J.; Tu, H.-L.; Stamou, D.; Groveset, J. Monitoring the waiting time sequence of single Ras GTPase activation events using liposome functionalized zero mode waveguides. Nano Lett. 2016, 16, 2890.
  4. Iversen, L.*; Tu, H.-L.* et al. Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics. Science 2014, 345, 50. (*: equal contribution)
  5. Lin, W.-C.*; Iversen, L.*; Tu, H.-L. et al. H-Ras forms dimers on membrane surfaces via a protein-protein interface. Proc. Natl. Acad. Sci. 2014, 111, 2996. (*: equal contribution)
  6. Lohmüller, T.; Iversen, L.; Schmidt, M.; Rhodes, C.; Tu, H.-L.; Lin, W.-C.; Groves, J. Single molecule tracking on supported membranes with arrays of optical nanoantennas. Nano Lett. 2012, 12, 1717.
  7. Tu, H.-L.; Lin, Y.-S.; Lin, H.-Y.; Hung, Y.; Lo, L.-W.; Chen, Y.-F.; Mou, C.-Y. In-vitro studies of functionalized mesoporous silica nanoparticles for photodynamic therapy. Adv. Mater. 2009, 21, 172.
  8. Tu, H.-L.; Tsai, F.-Y.; Mou, C.-Y. One step synthesis of ordered mesostructural organic/silica nanocomposite with tunable fluorescence surfactants. J. Mater. Chem. 2008, 18, 1771.
  9. Tsai, F.-Y.; Tu, H.-L.; Mou, C.-Y. Nonionic fluorescent oligomeric surfactant for ordered mesoporous silica structure. J. Mater. Chem. 2006, 16, 348.

Update: 2017-07-28

期刊論文
  1. Sune M. Christensen, Meredith G. Triplet, Christopher Rhodes, Jeffrey S. Iwig, Hsiung-Lin Tu, Dimitrios Stamou, Jay T. Groves Monitoring The Waiting Time Sequence of Single Ras GTPase Activation Events Using Liposome Functionalized Zero Mode Waveguides. NANO LETTERS 201616, 2890-2895.
  2. Sune M Christensen, Hsiung-Lin Tu, Jesse E Jun, Steven Alvarez, Meredith G Triplet, Jeffrey S Iwig, Kamlesh K Yadav, Dafna Bar-Sagi, Jeroen P Roose, Jay T Groves One-way Membrane Trafficking of SOS in Receptor-Triggered Ras Activation. NATURE STRUCTURAL & MOLECULAR BIOLOGY 201623, 838-846.
  3. William Y. C. Huang, Qingrong Yan, Wan-Chen Lin, Jean K. Chung, Scott D. Hansen, Sune M. Christensen, Hsiung-Lin Tu, John Kuriyan, Jay T. Groves Phosphotyrosine-mediated LAT Assembly on Membranes Drives Kinetic Bifurcation in Recruitment Dynamics of The Ras Activator SOS. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2016113, 8218-8223.
  4. Wan-Chen Lin, Lars Iversen, Hsiung-Lin Tu, Christopher Rhodes, Sune M. Christensen, Jeffrey S. Iwig, Scott D. Hansen, William Y. C. Huang, Jay T. Groves H-Ras Forms Dimers on Membrane Surfaces via A Protein-Protein Interface. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2014111, 2996-3001.
  5. Lars Iversen, Hsiung-Lin Tu, Wan-Chen Lin, Sune M. Christensen, Steven M. Abel, Jeff Iwig, Hung-Jen Wu, Jodi Gureasko, Christopher Rhodes, Rebecca S. Petit, Scott D. Hansen, Peter Thill, Cheng-Han Yu, Dimitrios Stamou, Arup K. Chakraborty, John Kuriyan, Jay T. Groves Ras Activation by SOS: Allosteric Regulation by Altered Fluctuation Dynamics. SCIENCE 2014345, 50-54.
  6. T. Lohmüller, L. Iversen, M. Schmidt, C. Rhodes, Hsiung-Lin Tu, W.-C. Lin, J. T. Groves Single Molecule Tracking on Supported Membranes with Arrays of Optical Nanoantennas. NANO LETTERS 201212, 1717-1721.
  7. Hsiung-Lin Tu, Yu-Shen Lin, Hsia-Yu Lin, Yann Hung, Leu-Wei Lo, Yang-Fang Chen, Chung-Yuan Mou In-vitro Studies of Functionalized Mesoporous Silica Nanoparticles for Photodynamic Therapy. ADVANCED MATERIALS 200921, 172-177.
  8. Hsiung-Lin Tu, Fu-Yu Tsai, C.-Y. Mou One Step Synthesis of Ordered Mesostructural Organic/silica Nanocomposite with Tunable Fluorescence Surfactants. JOURNAL OF MATERIALS CHEMISTRY 200818, 1771-1778.
  9. Fu-Yu Tsai, Hsiung-Lin Tu, Chung-Yuan Mou. Nonionic Fluorescent Oligomeric Surfactant for Ordered Mesoporous Silica Structure. JOURNAL OF MATERIALS CHEMISTRY 200616, 348-350.