Chein, Rong-Jie

Organic Synthesis, Asymmetric Catalysis, Natural Products Synthesis

Chein, Rong-Jie (陳榮傑)

    886-2-27898526
    886-2-27831237
    rjchein
    Chein, Rong-Jie 's Lab
Associate Research Fellow(2015-);Assistant Research Fellow (2009-2015);B.S., National Chiao Tung University (1994);Ph.D., National Chiao Tung University (2005);Postdoctoral Fellow, Harvard University, USA (2007-2009) ;
Research Interests

Development of new synthetic strategies and methods
Asymmetric Catalysis - interdisciplinary research that combines organic, inorganic, organometallic, and biomimetic chemistry
Total synthesis of natural products and designed molecules
Drug Discovery - Type 2 Diabetes, Neurodegenerative Disease



Selected Publications
  1. King, K.; Lin, N.-P.; Cheng, Y.-H.; Chen, G.-H.; Chein, R.-J. Isolation of a Positive Modulator of GLP-1 Signaling from the Seed of Trigonella foenum-graecum (Fenugreek). J. Biol. Chem. 2015, 290, 26235.
  2. Wang, S.-H.; Chein, R.-J. (Thiolan-2-yl)diphenylmethyl Benzyl Ether/N,N'-diarylurea Cocatalyzed Asymmetric Aziridination of Cinnamyl Bromide and Aryl Aldimine. Tetrahedron (Symposium-in-Print, Invited Article), 2015, DOI:10.1016/j.tet.2014.12.063.
  3. Wang, D.; Chen, M.; Chein, R.-J.; Ching, W.-M.; Hung, C.-H.; Tzou, D.-L. M. Cations Specifically Induce a Conformational Change in trans-Dehydroandrosterone: A Solid-State NMR Study. Steroids, 2015, 96, 73.
  4. Lo, H.-J.; Lin, C.-Y.; Tseng, M.-C.; Chein, R.-J. Lithiation of a Silyl Ether; Formation on an ortho-Fries Hydroxyketone. Angew. Chem. Int. Ed. 2014, 53, 9026.
  5. Lin, C.-Y.; Chein, R.-J. Lithiation of a Silyl Ether: Anionic Si→C Alkyl Migration. SYNLETT 2014, 25, 2827.
  6. Kumar, C. N. S. S. P.; Chein, R.-J. Synthesis of Labdane Diterpenes Galanal A and B from (+)-Sclareolide Org. Lett. 2014, 16, 2990.
  7. Siddappa, R. K. G.; Chang, C.-W.; Chein, R.-J. From Precursor to Catalyst: The Involvement of [Ru(ƞ5-Cp*)Cl2>]2 in Highly Branch Selective Allylic Etherfication of Cinnamyl Chloride Tetrahedron Lett. 2014, 55, 1031.
  8. Huang, M.-T.; Wu, H.-Y.; Chein, R.-J. Enantioselective Synthesis of Diaryl Aziridines Using Tetrahydrothiophene-Based Chiral Sulfides as Organocatalysts Chem. Commun. 2014, 50, 1101.
  9. Wu, H.-Y.; Chang, C.-W.; Chein, R.-J. Enantioselective Synthesis of (Thiolan-2-yl)diphenylmethanol and Its Application in Asymmetric, Catalytic Sulfur Ylide-Mediated Epoxidation J. Org. Chem. 2013, 78, 5788.
  10. Chang, C.-W.; Chein, R.-J. Absolute Configuration of Anti-HIV-1 Agent (−)-Concentricolide: Total Synthesis of (+)-(R)-Concentricolide. J. Org. Chem. 2011, 76, 4154.
  11. Chein, R.-J.; Corey, E. J. Strong Conformational Preferences of Heteroaromatic Ethers and Electron Pair Repulsion. Organic Letters 2010, 12, 132.
  12. Chein, R.-J.; Yeung, Y.-Y.; Corey, E. J. Highly Enantioselective Oxazaborolidine-Catalyzed Reduction of 1,3-Dicarbonyl Compounds: Role of the Additive Diethylaniline. Organic Letters 2009, 11, 1611.
  13. Kurti, L.; Chein, R.-J.; Corey, E. J. Conformational Energetics of Cationic Backbone Rearrangements in Triterpenoid Biosynthesis Provide an Insight into Enzymatic Control of Product. J. Am. Chem. Soc. 2008, 130, 9031.
  14. Yeung, Y.-Y.; Chein, R.-J.; Corey, E. J. Conversion of Torgov’s Synthesis of Estrone into a Highly Enantioselective and Efficient Process. J. Am. Chem. Soc. 2007, 129, 10346.
  15. Ho, T.-L.; Chein, R.-J. Ritter Reaction of 1-Aryl-1-fluoro-2-haloethanes. J. Chin. Chem. Soc. 2006, 53, 429.
  16. Ho, T.-L.; Chein, R.-J. Total Synthesis of (+)-β-Himachalene. Helv. Chim. Act. 2006, 89, 231.
  17. Ho, T.-L.; Chein, R.-J. Unusual Thionation via Fragmentation. J. Chin. Chem. Soc. 2005, 52, 1223.
  18. Ho, T.-L.; Chein, R.-J. Intervention of Phenonium Ion in Ritter Reactions. J. Org. Chem. 2004, 69, 591.
  19. Ho, T.-L.; Kung, L.-R.; Chein, R.-J. Total Synthesis of (±)-2-Isocyanoallopupukeanane. J. Org. Chem. 2000, 65, 5774.
  20. Ho, T.-L.; Chein, R.-J. A Synthesis of 6-Myoporol. J. Nat. Prod. 1997, 60, 493.
  21. Ho, T.-L.; Chein, R.-J. Synthesis of (-)-Furodysinin from (+)-Limonene. Chem. Commun. 1996, 1147.

Update: 2016-01-06

Journal Paper
  1. Singam Naveen Kumar, Isaac Furay Yu, Rong-Jie Chein* Oxathiaborolium: a Type of Chiral Lewis Acid Catalyst and Its Application in Catalytic and Highly Enantioselective Diels−Alder Reactions. ORGANIC LETTERS 2017-0119, 22-25.
  2. Shih-Che Lin, Rong-Jie Chein* Total Synthesis of the Labdane Diterpenes Galanal A and Galanal B from Geraniol. JOURNAL OF ORGANIC CHEMISTRY 2016-182, 1575-1583.
  3. Shang-Hua Wang, and Rong-Jie Chein* (Thiolan-2-yl)diphenylmethyl Benzyl Ether/N,N'-diarylurea Cocatalyzed Asymmetric Aziridination of Cinnamyl Bromide and Aryl Aldimine. TETRAHEDRON 2016-0372, 2607-2615.
  4. Chia-I Yen, Szu-Mam Liu, Wei-Shang Lo, Jhe-Wei Wu, Yi-Hsin Liu, Rong-Jie Chein, Renqiang Yang, Kevin C.-W. Wu, Jih Ru Hwu, Nianhan Ma,* Fa-Kuen Shieh* Cytotoxicityof Postmodified Zeolitic-Imidazolate Framework-90 (ZIF-90) Nanocrystals: Correlation between Functionality and Toxicity. CHEMISTRY-A EUROPEAN JOURNAL 2016-0122, 2925-2929.
  5. Klim King*, Nai-Pin Lin, Yu-Hong Cheng, Gao-Hui Chen, Rong-Jie Chein* Isolation of Positive Modulator of Glucagon-like Peptide-1 Signaling from Trigonella foenum-graecum (Fenugreek) Seed. JOURNAL OF BIOLOGICAL CHEMISTRY 2015-09, doi:10.1074/jbc.M115.684274.
  6. Darong Wang, Meiman Chen, Rong-Jie Chein, Wei-Min Ching, Chen-Hsiung Hung, Der-Lii M. Tzou* Cation ion specifically induces a conformational change in trans-dehydroandrosterone – A solid-state NMR study. STEROIDS 2015-0496, 73-80.
  7. Chin-Yin Lin, Rong-Jie Chein* Lithiation of a Silyl Ether: Anionic Si→C Alkyl Migration. SYNLETT 2014-1225, 2827–2830.
  8. Chebolu Naga Sesha Sai Pavan Kumar, Rong-Jie Chein* Synthesis of Labdane Diterpenes Galanal A and B from (+)–Sclareolide. ORGANIC LETTERS 2014-0616, 2990−2992.
  9. Meng-Ting Huang, Hsin-Yi Wu, Rong-Jie Chein* Enantioselective Synthesis of Diaryl Aziridines Using Tetrahydrothiophene-Based Chiral Sulfides as Organocatalysts. CHEMICAL COMMUNICATIONS 2014-0150, 1101-1103.
  10. Ravi Kumara Guralamatta Siddappa, Chih-Wei Chang, Rong-Jie Chein From Precursor to Catalyst: The Involvement of [Ru(ƞ5-Cp*)Cl2]2 in Highly Branch Selective Allylic Etherfication of Cinnamyl Chloride. TETRAHEDRON LETTERS 2014-0155, 1031-1035.
  11. Hong-Jay Lo, Chin-Yin Lin, Mei-Chun Tseng, and Rong-Jie Chein* Lithiation of a Silyl Ether; Formation on an ortho-Fries Hydroxyketone. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 201453, 9026 –9029.
  12. Hsin-Yi Wu, Chih-Wei Chang, Rong-Jie Chein* Enantioselective Synthesis of (Thiolan-2-yl)diphenylmethanol and Its Application in Asymmetric, Catalytic Sulfur Ylide-Mediated Epoxidation. JOURNAL OF ORGANIC CHEMISTRY 2013-0578, 5788-5793.
  13. Chih-Wei Chang, Rong-Jie Chein* The Absolute Configuration of Anti-HIV-1 Agent (-)-Concentricolide : Total Synthesis of (+)-(R)-Concentricolide. JOURNAL OF ORGANIC CHEMISTRY 2011-0476(10), 4154-4157.
  14. Rong-Jie Chein, E. J. Corey* Strong Conformational Preferences of Heteroaromatic Ethers and Electron Pair Repulsion. ORGANIC LETTERS 2010-0112(1), 132-135.