My laboratory is interested in elucidating the structure and function of biological macromolecules in yeast and human cells, especially these molecules governing the transfer of genetic information, such as RNA polymerase I, II, III, DNA repair enzymes, splicing particles, and various kinds of infectious virus such as influenza and EV71. How these macromolecules interact with their partners and how these molecules change their conformations when they act upon their targets? These questions have to be answered by a combination of various techniques. To this end, our lab is developing chemical methods to label these macromolecules in vitro and also in vivo and aiming to image them with single molecule microscopy, such as FRET, PALM, and cryo electron microscopy. We are also applying yeast genetics and chemical synthesis to design novel bio-conjugation strategies, and developing new image analysis algorithm for analyzing single particle electron microscope images. We welcome students and postdocs with the background of chemistry, biology, physics, mathematics, and electric engineering to join our venture at this frontier.