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Wen-Shan Li (李文山)

Medicinal and Bioorganic Chemistry

Wen-Shan Li (李文山)

    886-2-27898662
    886-2-27831237
    wenshanemail圖片
    Wen-Shan Li 's Lab
Associate Research Fellow (2007-);Assistant Research Fellow (2001-2007);B.S., National Taiwan Normal University (1981-1986);M.S., National Taiwan Normal University (1986-1989);Teaching and Research Assistant (1985-1989, 1991-1992);Ph.D., Case Western Reserve University (1992-1997);Postdoctoral Research Fellow, Purdue University (1997-1999);Postdoctoral Research Fellow, Texas A&M University (1999-2001) ;
Research Interests

Drug Discovery in Antimetastatic and Antiproliferative Agents: Expanding access to lead identification through natural product screening and organic synthesis allows the discovery of invaluable new chemical entities against cancers.
Cellular (Animal) Studies: Identification of cellular target protein, pathway and drug metabolites in vitro (via strategy of bionanotechnology) and in vivo.
Enzyme Kinetics and Mechanism: Elucidation of catalytic mechanism for proton relay system and its biological role in vitro and in vivo.
Enzymatic Bioremediation: Discovery of new functions of proteins to detoxify the environmental contaminants (insecticides) and exploration of detoxification pathways.
Artificial enzyme: Establishing the catalytic power of artificial catalyst, mimic of the active site complex of metalloenzyme.

研究圖片1

Selected Publications
  1. Chen, J. –Y.; Tang, Y. –A.; Huang, S. –M.; Juan, H. –F.; Wu, L. –W.; Sun, Y. –C.; Wang, S. –C.; Wu, K.-W.; Balraj, G.; Chang, T. –T.; Li, W. –S.; Cheng, H. –C.; Wang, Y. –C. A novel sialyltransferase inhibitor suppresses FAK/Paxillin signaling and cancer angiogenesis and metastasis pathways. Cancer Res. 2011, 71, 473.
  2. Chiang, C. –H.; Wang, C. –H.; Chang, H. –C.; More, S. V.; Li, W. –S.; Hung, W. –C. A novel sialyltransferase inhibitor AL10 suppresses invasion and metastasis of lung cancer cells by inhibiting integrin-mediated signaling. J. Cell. Physiol. 2010, 223, 492.
  3. Li, W. –S.; Lam, W. S.; Liu, K. –C.; Wang, C. –H.; Chang, H. C.; Jen, Y. C.; Hsu, Y. –T.; Shivatare, S.; Jao, S. –C. Overcoming the Drug Resistance in Breast Cancer Cells by Rational Design of Efficient Glutathione S-Transferase Inhibitors. Organic Lett. 2010, 12, 20.
  4. Li, W. –S.; More, S. V.; Wang, C. –H.; Jen, Y. C.; Yao, C. –F.; Wang, T. –F.; Hung, C. –C.; Jao, S. –C. Synthesis and Structure-activity Relationships of Novel Furazan-3,4-diamide Analogs as Potent Anti-cancer Agents. Bioorg. Med. Chem. Lett. 2010, 20, 1148.
  5. Li, W.-S.; Wang, Y.-C.; Juan, H.-F. Preparation of Lithocholic Acid Analogs that Inhibit Sialyltransferase. 2008, U.S. Pat. Appl. Publ. 35pp. CODEN: USXXCO US 2008119443 A1 20080522.
  6. Hsu, Y.-T.; Su, C.-Y.; Du, H.-C.; Jao, S.-C.; Li, W.-S. Evaluation of Organophosphorus Chemicals-Degrading Enzymes: A Comparison of Escherichia coli and Human Cytosolic Aminopeptidase P. Chem. Biodivers 2008, 5, 1401.
  7. Ling, K.-Q.; Li, W.-S.; Sayre, L. M. Oxidations of N-(3-Indoleethyl) Cyclic Aliphatic Amines by Horseradish Peroxidase: The Indole Ring Binds to the Enzyme and Mediates Electron-Transfer Amine Oxidation. J. Am. Chem. Soc. 2008, 130, 933.
  8. Lo, W.-J.; Chiou, Y.-C.; Hsu, Y.-T.; Lam, W. S.; Chang, M.-Y.; Jao, S.-C.; Li, W.-S. Enzymatic and Nonenzymatic Synthesis of Glutathione Conjugates: Application to the Understanding of Parasite’s Defense System and Alternative to the Discovery of Potent Glutathione S-Transferase Inhibitors. Bioconjugate Chem. 2007, 18, 109.
  9. Lee, L.; Chang, K. H.; Valiyev, F.; Liuc, H. J.; Li, W.-S. Synthesis and Biological Evaluation of 5'-Triazole Nucleosides. J. Chin. Chem. Soc. 2006, 53, 1547.
  10. Jao, S.-C.; Chen, J.; Yang, K.; Li, W.-S. Design of Potent Inhibitors for Schistosoma Japonica Glutathione S-Transferase. Bioorg. Med. Chem. 2006, 14, 304.
  11. Du, H.-C.; Liu, K.-C.; Li, W.-S. Catalytic Hydrogenation of Halo-Steroidal Derivatives by Bipyridine or Phenanthroline Complexes of Copper(II) in Hydrazine Aqueous Media. Synth. Commun. 2006, 36, 621.
  12. Huang, L.-F.; Su, B.; Jao, S.-C.; Liu, K.-T.; Li, W.-S. Aminopeptidase P-mediated Detoxification of Organophosphonate Analogues of Sarin: Mechanistic and Stereochemical Study at Phosphorus Atom of Substrate. ChemBioChem, 2006, 7, 506.
  13. Chang, K.-H.; Lee, L.; Chen, J.; Li, W.-S. Lithocholic Acid Analogues, New and Potent a-2,3-Sialyltransferase Inhibitors. Chem Comm. 2006, 629. (This communication will be highlighted in the supplement Chemical Biology of Royal Society of Chemistry, 2006( http://www.rsc.org/Publishing/Journals/cb/Volume/2006/3/Index.asp ).
  14. Jao, S.-C.; Huang, L.-F.; Hwang, S.-M.; Li, W.-S. Tyrosine 387 and Arginine 404 Are Critical in the Hydrolytic Mechanism of Escherichia coli Aminopeptidase P. Biochemistry 2006, 45, 1547.
  15. Jao, S.-C.; Huang, L.-F.; Tao, Y. S.; Li, W.-S. Hydrolysis of Organophosphate Triesters by Escherichia coli Aminopeptidase P. J. Mol. Cat. B: Enzym. 2004, 27, 7.
  16. Chang, K.-H.; Tao, Y. S.; Li, W.-S. Synthesis of Anomeric Sulfur Analogues of CMP-Neu5Ac Containing Tethered Alkane or Arene. Synlett. 2004, 1, 37.
  17. Hill, C. M.; Li, W.-S.; Thoden, J. B.; Holden, H. M.; Raushel, F. M. Enhanced Degradation of Chemical Warfare Agents through Molecular Engineering of Enzyme Active Sites. J. Am. Chem. Soc. 2003, 125, 8990.
  18. Li, W.-S.; Torun, L.; Morrison, H. Intramolecular Sensitization within Steroids. Excited State Interaction of C17 Alpha and Beta Carbon-bromine Bonds with a C6 Carbonyl Group. Can. J. Chem. 2003, 81, 1.
  19. Chang, K.-H.; Jenkins, M. N.; Wu; H.-R.; Li, W.-S. A Selective Cu(II)/Fe(III)-mediated Hydrogenation of Steroidal Haloalkenes in the Presence of Hydrazine. Tetrahedron Lett. 2003, 44, 1351.
  20. Li, W.-S.; Li, Y.; Hill, C. M.; Lum, K.; Raushel, F. M. Enzymatic Synthesis of Chiral Organophosphothioates from Prochiral Precursors. J. Am. Chem. Soc. 2002,124, 3498.
  21. Hill, C. M.; Li, W.-S.; Cheng, T.-C.; DeFrank, J. J.; Raushel, F. M. Stereochemical Specificity of Organophosphorus Acid Anhydrolase Toward p-Nitrophenyl Analogs of Soman and Sarin. Bioorganic Chemistry 2001, 29, 27.
  22. Li, W.-S.; Zhang, N.; Sayre, L. M. N1, N10-Ethylene-Bridged High-Potential Flavins: Synthesis, Characterization, and Reactivity. Tetrahedron 2001, 57, 4507.
  23. Li, W.-S.; Sayre, L. M. Reaction of Amines with N1, N10-Ethylene-Bridged Flavinium Salts: The First NMR Spectroscopic Evidence of C10a Tetrahedral Amine Adducts. Tetrahedron 2001, 57, 4523.
  24. Li, W.-S.; Lum, K. T.; Chen-Goodspeed, M.; Sogorb, M. A.; Raushel, F. M. Stereoselective Detoxification of Chiral Sarin and Soman Analogs by Phosphotriesterase. Bioorg. Med. Chem. 2001, 9, 2083.
  25. Li, W.-S.; Morrison, H. Long-Range Through-Bond Photoactivated s Bond Cleavage in Steroids. Intramolecular Sensitized Debromination. Organic Letter 2000, 2, 15.
  26. Zhu, W.; Li, W.-S.; Raushel, F. M.; Vigh, G. Experimental Verification of a Predicted, Previously Unseen Separation Selectivity Pattern in the Capillary Electrophoretic Separation of Noncharged Enantiomers by Octakis(2, 3-diacetyl-6-sulfato)-g-Cyclodextrin. Electrophoresis 2000, 21, 3249.
  27. Wu, F.; Li, W.-S.; Chen-Goodspeed, M.; Sogorb, M. A.; Raushel, F. M. Rationally Engineered Mutants of Phosphotriesterase for Preparative Scale Isolation of Chiral Organophosphates. J. Am. Chem. Soc. 2000, 122, 10206.

Update: 2015-03-23

Journal Paper
  1. Chi-Che Hsieh, Yi-Ming Shyr, Wen-Ying Liao, Tien-Hua Chen, Shin-E Wang, Peir-Chuen Lu, Pei-Yu Lin, Yan-Bo Chen, Wan-Yu Mao, Hsin-Ying Han, Michael Hsiao, Wen-Bin Yang, Wen-Shan Li, Yuh-Pyng Sher, Chia-Ning Shen* Elevation of beta-galactoside alpha2,6-sialyltransferase 1 in a fructoseresponsive manner promotes pancreatic cancer metastasis.. Oncotarget 20178, 7691-7709.
  2. Chia-Chueng Chen, Bor-Cherng Hong*, Wen-Shan Li*, Tzu-Ting Chang, Gene-Hsiang Lee Synthesis Of Biologically Active Bis(Indolyl)Methane Derivatives by Bisindole Alkylation of Tetrahydroisoquinolines with Visible-Light Induced Ring-Opening Fragmentation. ASIAN JOURNAL OF CHEMISTRY 20176, 426-431.
  3. Irulappan Manikandan, Chien-Huei Chang, Chia-Ling Chen, Veerasamy Sathish, Wen-Shan Li*, Mahalingam Malathi* Aggregation induced emission enhancement (AIEE) characteristics of quinoline based compound — A versatile fluorescent probe for pH, Fe(III) ion, BSA binding and optical cell imaging. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2017182, 58-66.
  4. Chih-Wei Fu, Kai-Hsuan Chang, Ya Ching Jen, Tzu Ting Chang, Wen-Shan Li* Synthesis of Amino Acid-comprising Sialyltransferase Inhibitors and Their Antimetastatic Activities against Human Breast Cancer Cells. JOURNAL OF THE CHINESE CHEMICAL SOCIETY 2016-0163, 171–180.
  5. Abdu-Allah HH, Chang TT, Li WS* Synthesis of B- and C-ring-modified lithocholic acid analogues as potential sialyltransferase inhibitors.. Steroids 2016112, 54-61.
  6. Abdu-Allah HH, Huang ST, Chang TT, Chen CL, Wu HC,* Li WS* Nature-inspired design of tetraindoles: Optimization of the core structure and evaluation of structure-activity relationship.. Bioorganic & medicinal chemistry letters 201626(18), 4497-503.
  7. Chih-Wei Fu, Yun-Jung Hsieh, Tzu Ting Chang, Chia-Ling Chen, Cheng-Yu Yang, Anne Liao, Pei-Wen Hsiao, Wen-Shan Li* Anticancer efficacy of unique pyridine-based tetraindoles. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2015-11104, 165-176.
  8. Mohammad Hassam, Wen-Shan Li* Copper-catalyzed Markovnikov hydration of alkynes. TETRAHEDRON 2015-0271, 2719–2723.
  9. Mei-Lin Su, Tsung-Ming Chang, Chi-Hsiang Chiang, Han-Chen Chang, Ming-Feng Hou, Wen-Shan Li*, Wen-Chun Hung* Inhibition of Chemokine (C-C Motif) Receptor 7 Sialylation Suppresses CCL19-Stimulated Proliferation, Invasion and Anti-Anoikis. PLoS One 2014-069(6), e98823.
  10. Chie-Hong Wang, Chia-Ling Chen, Shivaji V. More, Pei-Wen Hsiao, Wen-Chun Hung*, Wen-Shan Li* The Tetraindole SK228 Reverses the Epithelial-to-Mesenchymal Transition of Breast Cancer Cells by Up-Regulating Members of the miR-200 Family. PLoS One 2014-069(6), e101088.
  11. Mohammad Hassam, Shivaji V. More and Wen-Shan Li* Synthesis of nitrogen-containing benzoannulated eight- and nine-membered heterocycles from methyl 4-amino-3-iodobenzoate. MENDELEEV COMMUNICATIONS 2014-0324, 159–160.
  12. Veerasamy Sathish, Eththilu Babu, Arumugam Ramdass, Zong-Zhan Lu, Tzu-Ting Chang, Murugesan Velayudham, Pounraj Thanasekaran, Kuang-Lieh Lu*, Wen-Shan Li* and Seenivasan Rajagopal* Photoswitchable alkoxy-bridged binuclear rhenium(I) complexes – a potential probe for biomolecules and optical cell imaging. RSC Adv. 2013-113, 18557-18566.
  13. Ramaiyan Sekar, Suresh Kumar Kailas, Wen-Shan Li, Han-Chung Wu, Hui-Fen Wu* Rapid separation of acetophenone and its monohydroxy isomers by capillary electrophoresis. CHINESE CHEMICAL LETTERS 2013-0624, 833-836.
  14. Jia-Yang Chen, Yen-An Tang, Wen-Shan Li, Yu-Ching Chiou, Jiunn-Min Shieh, Yi-Ching Wang A Synthetic Podophyllotoxin Derivative Exerts Anti-Cancer Effects by Inducing Mitotic Arrest and Pro-Apoptotic ER Stress in Lung Cancer Preclinical Models. PLoS One 2013-04, 8(4): e62082.
  15. Shivaji V. More, Tzu Ting Chang, Yu-Pin Chiao, Shu-Chuan Jao, Chung-Kuang Lu, Wen-Shan Li* Glycosylation Enhances the Anti-migratory Activities of Isomalyngamide A Analogs. Eur. J. Med. Chem. 2013-0364,169-178.
  16. Sin-Ming Huang, Pei-Chun Hsu, Mei-Yu Chen, Wen-Shan Li, Shivaji V. More, Kwok-Tung Lu, Yi-Ching Wang* The novel indole compound SK228 induces apoptosis and FAK/Paxillin disruption in tumor cell lines and inhibits growth of tumor graft in the nude mouse. INTERNATIONAL JOURNAL OF CANCER 2012-08131, 722–732.
  17. Wen-Shan Li*, Chie-Hong Wang, Shengkai Ko, Tzu Ting Chang, Ya Ching Jen, Ching-Fa Yao*, Shivaji V. More and Shu-Chuan Jao  Synthesis and Evaluation of the Cytotoxicities of Tetraindoles: Observation that the 5-Hydroxy Tetraindole (SK228) Induces G2 Arrest and Apoptosis in Human Breast Cancer Cells. JOURNAL OF MEDICINAL CHEMISTRY 2012-0355, 1583−1592.
  18. Chie-Hong Wang, Ho T. Wu, Hau Man Cheng, Tien-Jui Yen, I-Hsuan Lu, Hui Chuan Chang, Shu-Chuan Jao, Tony Kung Ming Shing*, and Wen-Shan Li* Inhibition of Glutathione S-Transferase M1 by New Gabosine Analogues Is Essential for Overcoming Cisplatin Resistance in Lung Cancer Cells. JOURNAL OF MEDICINAL CHEMISTRY 2011-1254, 8574−8581.
  19. Chie-Hong Wang, Wei-Chih Shih, Hui Chuan Chang, Yi-Yun Kuo, Wen-Chun Hung,Tiow Gan Ong,* and Wen-Shan Li,*  Preparation and characterization of amino-linked heterocyclic carbene palladium, gold, and silver complexes and their use as anticancer agents that act by triggering apoptotic cell death. JOURNAL OF MEDICINAL CHEMISTRY 2011-0854, 5245-5249..
  20. Tzu Ting Chang, Shivaji V. More, I-Hsuan Lu, Jui-Ching Hsu, Ting-Ju Chen, Ya Ching Jen, Chung-Kuang Lu,* and Wen-Shan Li,* Isomalyngamide A, A-1 and their analogs suppress cancer cell migration in vitro. Eur. J. Med. Chem. 2011-0346, 3810-3819..
  21. Tzu Ting Chang, Shivaji V. More, Norman Lu,* Jyun-Wei Jhuo, Yi-Chuan Chen, Shu-Chuan Jao, and Wen-Shan Li,* Polyfluorinated bipyridine cisplatins manipulate cytotoxicity through the induction of S-G2/M arrest and partial intercalation mechanism. BIOORGANIC & MEDICINAL CHEMISTRY 2011-0119, 4887-4894..
  22. Jia-Yang Chen, Yen-An Tang, Sin-Ming Huang, Hsueh-Fen Juan, Li-Wha Wu, Ying-Chieh Sun, Szu-Chi Wang, Kuan-Wei Wu, Gopula Balraj, Tzu-Ting Chang, Wen-Shan Li*, Hung-Chi Cheng*, and Yi-Ching Wang* A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways. CANCER RESEARCH 2011-0171(2), 473-483.
  23. Chi-Hsiang Chiang, Chie-Hong Wang, Hui-Chiu Chang, Shivaji V. More, Wen-Shan Li*, Wen-Chun Hung* A novel sialyltransferase inhibitor AL10 suppresses invasion and metastasis of lung cancer cells by inhibiting integrin-mediated signaling. JOURNAL OF CELLULAR PHYSIOLOGY 2010-03223, 492-499.
  24. Wen-Shan Li*, Wing See Lam, Kung-Cheng Liu, Chie-Hong Wang, Hui Chuan Chang,Ya Ching Jen,Yu-Ting Hsu, Sachin Shivatare, Shu-Chuan Jao Overcoming the Drug Resistance in Breast Cancer Cells by Rational Design of Efficient Glutathione S-Transferase Inhibitors. ORGANIC LETTERS 2010-0212, 20-23..
  25. Wen-Shan Li*, Shivaji V. More, Chie-Hong Wang, Ya Ching Jen, Ching-Fa Yao, Tein-Fu Wang, Chin-Chun Hung, Shu-Chuan Jao Synthesis and Structure-activity Relationships of Novel Furazan-3,4-diamide Analogs as Potent Anti-cancer Agents. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2010-0120, 1148-1152.
  26. Ling KQ, Li WS, Sayre LM Oxidations of N-(3-indoleethyl) cyclic aliphatic amines by horseradish peroxidase: the indole ring binds to the enzyme and mediates electron-transfer amine oxidation.. Journal of the American Chemical Society 2008130(3), 933-44.
  27. Hsu YT, Su CY, Du HC, Jao SC, Li WS Evaluation of organophosphorus chemicals-degrading enzymes: a comparison of Escherichia coli and human cytosolic aminopeptidase P.. Chemistry & biodiversity 20085(7), 1401-11.
  28. Lo, W.-J.; Chiou, Y.-C.; Hsu, Y.-T.; Lam, W. S.; Chang, M.-Y.; Jao, S.-C.; Li, W.-S.* Enzymatic and nonenzymatic synthesis of glutathione conjugates: application to the understanding of a parasite's defense system and alternative to the discovery of potent glutathione S-transferase inhibitors.. Bioconjugate Chem. 2007-0118(1), 109-20..
  29. Lee, Lenselot, Chang, KH, Valiyev, Famil, Liuc, HJ and Li, WS Synthesis and Biological Evaluation of 5'-Triazole Nucleosides. J. Chin. Chem. Soc. 2006-0853, 1547-1555.
  30. Huang, LF, Su, BS, Jao, SC, Liu, KT and Li, WS Aminopeptidase P mediated detoxification of organophosphonate analogues of sarin: Mechanistic and sterecichemical study at the phosphorus atom of the substrate. CHEMBIOCHEM 2006-037(3), 506-514.
  31. Chang, KH, Lee, L, Chen, J and Li, WS Lithocholic acid analogues, new and potent alpha-2,3-sialyltransferase inhibitors. CHEMICAL COMMUNICATIONS 2006-02(6), 629-631.
  32. Jao, SC, Huang, LF, Hwang, SM and Li, WS Tyrosine 387 and arginine 404 are critical in the hydrolytic mechanism of Escherichia coli aminopeptidase P. BIOCHEMISTRY 2006-0245(6), 1547-1553.
  33. Jao, SC, Chen, J, Yang, K and Li, WS Design of potent inhibitors for Schistosoma japonica glutathione S-transferase. BIOORGANIC & MEDICINAL CHEMISTRY 2006-0114(2), 304-318.
  34. Du, HC, Liu, KC and Li, WS Catalytic hydrogenation of halosteroidal derivatives by bipyridine or phenanthroline complexes of copper(II) in hydrazine aqueous media. SYNTHETIC COMMUNICATIONS 200636(5), 621-630.
  35. K.-H. Chang, Y. S. Tao and W.-S. Li* Synthesis of anomeric sulfur analogues of CMP-Neu5Ac containing tethered alkane or arene.. Synlett, 2004, 1(37).
  36. S.-C. Jao, L.-F. Huang, Y. S. Tao and W.-S. Li* Hydrolysis of organophosphate triesters by escherichia coli aminopeptidase P.. J. Mol. Catal. B: Enzym. 2004, 27(7).
  37. Craig M. Hill, Wen-Shan Li, James B. Thoden, Hazel M. Holden and Frank M. Raushel Enhanced Degradation of Chemical Warfare Agents through Molecular Engineering of Enzyme Active Sites. J. Am. Chem. Soc. 2003-07, 125(30):8990-1.
  38. K.-H. Chang, H.-R. Wu, M. N. Jenkins and W.-S. Li* A selective Cu(II)/Fe(III)-mediated hydrogenation of steroidal haloalkenes in the presence of hydrazine.. Tetrahedron Lett. 200344, 1351-1354.
  39. Wen-Shan Li, Yingchun Li, Craig M. Hill, Karin Lum and Frank M. Raushel Enzymatic Synthesis of Chiral Organophosphothioates from Prochiral Precursors. J. Am. Chem. Soc. 2002-04, 124(14):3498-9..
  40. Wen-Shan Li, Karin T. Lum, Misty Chen-Goodspeed, Miguel A. Sogorb and Frank M. Raushel Stereoselective Detoxification of Chiral Sarin and Soman Analogs by Phosphotriesterase. Bioorg. Med. Chem. 2001-08, 9(8):2083-91..
  41. Wen-Shan Li and Lawrence M. Sayre Reaction of Amines with N1, N10-Ethylene-Bridged Flavinium Salts: The First NMR Spectroscopic Evidence of C10a Tetrahedral Amine Adducts. Tetrahedron 2001-0657, 4523-4536..
  42. Wen-Shan Li, Nanjing Zhang and Lawrence M. Sayre N1, N10-Ethylene-Bridged High-Potential Flavins: Synthesis, Characterization, and Reactivity. Tetrahedron 2001-0657, 4507-4522..
  43. Craig M. Hill, Wen-Shan Li, Tu-Chen Cheng, Joseph J. DeFrank and Frank M. Raushel Stereochemical Specificity of Organophosphorus Acid Anhydrolase Toward p-Nitrophenyl Analogs of Soman and Sarin. Bioorganic Chemistry 2001-02, 29(1):27-35..
  44. Feiyue Wu, Wen-Shan Li, Misty Chen-Goodspeed, Miguel A. Sogorb and Frank M. Raushel Rationally Engineered Mutants of Phosphotriesterase for Preparative Scale Isolation of Chiral Organophosphates. J. Am. Chem. Soc. 2000-06122, 10206-10207.
  45. Wenhong Zhu, Wen-Shan Li, Frank M. Raushel and Gyula Vigh Experimental Verification of a Predicted, Previously Unseen Separation Selectivity Pattern in the Capillary Electrophoretic Separation of Noncharged Enantiomers by Octakis(2, 3-diacetyl-6-sulfato)--Cyclodextrin. Electrophoresis 2000-0321, 3249-3256.
  46. Wen-Shan Li and Harry Morrison Long-Range Through-Bond Photoactivated s Bond Cleavage in Steroids. Intramolecular Sensitized Debromination. Organic Letter 2000-01, 2(1):15-8..
  47. Lawrence M. Sayre, Robert T. Naismith II, Michael A. Bada, Wen-Shan Li, Molly E. Klein, and Mark D. Tennant trans-2-Phenylcyclopropylamine is a Substrate for and Inactivator of Horseradish Peroxidase. Biochim. Biophys. Acta 1996-09, 1296(2):250-6..
Paper of Conference (or Symposium)
  1. Han-En Tsai蔡函恩, Chih-Wei Fu傅志偉, Tzu-Ting Chang張梓庭, Chia-Ling Chen陳佳鈴 and Wen-Shan Li李文山*, 2016, “INVESTIGATE THE ROLE OF SIALYLTRANSFERASE INHIBITOR ON MDA-MB-231 BREAST CANCER CELLS IN VITRO AND IN VIVO”, paper presented at Tenth International Symposium for Chinese Medicinal Chemists (10th ISCMC), West Lake Resortopia/Arena Conference Center, Sanyi, Miaoli, TW: School of Pharmacy, National Taiwan University, 2016-01-18 ~ 2016-01-20.
  2. Wei-Chia Chen 陳維家, Chih-Wei Fu傅志偉, Chia-Ling Chen陳佳鈴, Wen-Shan Li李文山*, 2016, “SYNTHESIS AND ANTICANCER ACTIVITY EVALUATION OF OXADIAZOLOPYRAZINE DERIVATIVES”, paper presented at Tenth International Symposium for Chinese Medicinal Chemists (10th ISCMC), West Lake Resortopia/Arena Conference Center, Sanyi, Miaoli, TW: School of Pharmacy, National Taiwan University, 2016-01-18 ~ 2016-01-20.
  3. Wen-Shan Li,* Shivaji V. More, Mingxin Liu, Mohammad Hassam, Wan-June Tsai, Chien-Huei Chang, Chia-Ling Chen , 2015, ““ABX” Analogs: Fluorescent Dyes for Live Cell Imaging and Biological Applications”, PO-D18 pages, paper presented at The 10th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-10), 85 Sky Tower Hotel, Kaohsiung Taiwan: Asia Core Program, 2015-11-02 ~ 2015-11-05.
  4. Wen-Shan Li*, Tzu Ting Chang, Chien-Chin Hung, Chia-Ling Chen, Shu-Chuan Jao, 2014, “Synthetic Isomalyngamide A Analogs that Inhibit Breast Cancer Migration ”, 95 pages, paper presented at 第26屆EORTC-NCI-AACR分子靶標和癌症治療研討會, Spain、Barcelona: EORTC-NCI-AACR, 2014-11-18 ~ 2014-11-21.
  5. Wen-Shan Li*, Chie-Hong Wang, Chia-Ling Chen, Shu-Chuan Jao, 2014, “Tetraindole suppresses breast cancer growth and metastasis by reversing epithelial-mesenchymal transition state associated with up-regulation of the miR-200 family”, S44 pages, paper presented at 23屆雙年展EACR(歐洲癌症研究協會)會議, Munich, Germany: 歐洲癌症研究協會, 2014-07-05 ~ 2014-07-08.
  6. Wen-Shan Li*, Hui-Chuan Chang, Tzu-Ting Chang, Shu-Chuan Jao, 2013, “Evidence for Chemical Rescue of Proton Relay System for Human Cytosolic Aminopeptidase P”, paper presented at 第21屆國際會議---超速離心分析,流體動力學,熱力學和互補的方法, Atami, Japan: 日本蛋白質學會和日本生物物理學會, 2013-09-23 ~ 2013-09-28.
  7. Wen-Shan Li,*, Chih-Wei Fu, Tzu Ting Chang,a Yun-Jung Hsieh, Hajjaj H. M. Abdu-Allah, Shivaji V. More, Shu-Chuan Jao, 2012, “Nature-Inspired Design of Tetraindoles: Potential as Anticancer Agents”, paper presented at The 7th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-7) The 3rd New Phase International Conference on Cutting-Edge Organic Chemistry in Asia (NICCEOCA-3), Nanyang Technological University, Singapore: Nanyang Technological University, Singapore, 2012-12-11 ~ 2012-12-14.
  8. Wen-Shan Li*, Wing See Lam, Huang-Chi Du, Kung-Cheng Liu, Shu-Chuan Jao, 2012, “Overcoming the Drug Resistance in Cancer Cells by Glutathione S-Transferase Inhibitors”, paper presented at ISCOC-12 and ISCIC-9, Lan zhou University: Lan zhou University, 2012-08-19 ~ 2012-08-22.
  9. Wen-Shan Li,*, Kai-Hsuan Chang, Tzu Ting Chang, David Chang, Andrew Chiang, Chie-Hong Wang, Shu-Chuan Jao, 2012, “Sialyltransferase Inhibitors, Lithocholic Acid Analogues, Suppress Breast Cancer Metastasis in Vitro and in Vivo”, paper presented at 2012第27屆生物醫學聯合學術年會, 國防醫學院: 中華民國毒物學學會 ,台灣生物化學及分子生物學學會 ,中華民國細胞及分子生物學學會 ,中華民國臨床生化學會 ,中國生理學會 ,台灣藥理學會 ,中華民國解剖學學會, 2012-03-17 ~ 2012-03-18.
  10. Wang Chie-Hong 王啟鴻, Li Wen-Shan 李文山*, 2012, “A potent indole compound SK228 induces apoptosis and regulates epithelial-mesenchymal transition in human breast cancer cells”, paper presented at 2012第27屆生物醫學聯合學術年會, 國防醫學院: 中華民國毒物學學會 ,台灣生物化學及分子生物學學會 ,中華民國細胞及分子生物學學會 ,中華民國臨床生化學會 ,中國生理學會 ,台灣藥理學會 ,中華民國解剖學學會, 2012-03-17 ~ 2012-03-18.
  11. Tzu-Ting Chang, Shivaji V. More, Wen-Shan Li*, 2012, “Fatty Acid Amide Glycosides, Analogs of Isomalyngamide A, Suppress FAK/Paxillin Signaling and Cancer Metastasis”, paper presented at 2012第27屆生物醫學聯合學術年會, 國防醫學院: 中華民國毒物學學會 ,台灣生物化學及分子生物學學會 ,中華民國細胞及分子生物學學會 ,中華民國臨床生化學會 ,中國生理學會 ,台灣藥理學會 ,中華民國解剖學學會, 2012-03-17 ~ 2012-03-18.
  12. Wen-Shan Li, 2011, “Sialyltransferase Inhibitors, Lithocholic Acid Analogues, Suppress Breast Cancer Metastasis in Vitro and in Vivo”, 54 pages, paper presented at The 6th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-6) and The 2nd New Phase International Conference on Cutting-Edge Organic Chemistry in Asia (NICCEOCA-2), Hong Kong: The Chinese University of Hong Kong, 2011-12-11 ~ 2011-12-15.
  13. Tzu Ting Chang, Shivaji V. More, I-Hsuan Lu, Jui-Ching Hsu, Ting-Ju Chen, Ya Ching Jen, Shu-Chuan Jao, Chung-Kuang Lu,* and Wen-Shan Li*, 2010, “Isomalyngamide A, A‐1 and their analogs suppress cancer cell migration in vitro”, 194 pages, paper presented at OzBio Conference, Melbourne, Australia: IUBMB, FAOBMB, 2010-09-26 ~ 2010-10-01.
  14. Chang, T.T, More, S.V , Jen, Y.C., Hsu, J.C., Lu, C.K., Li, W.S, 2009, “Novel isomalyngamide A analogues that suppress cancer cell migration in vitro”, paper presented at 2009 Annual Meeting of Chinese Chemical Society, 義守大學燕巢分部: 義守大學燕巢分部生物科技學系, 2009-12-04 ~ 2009-12-06.
  15. Wei- Jen Chiang 江維恁 , Shivaji. V. More, Chi-Hong Wong 王啟鴻, Wen- Shan Li 李文山*, 2009, “Isolation and Identification of the Cellular Targets of Sialyltransferase Inhibitors by Using Cell-permeable Magnetic Nanoparticle Probes”, paper presented at 2009 Annual Meeting of Chinese Chemical Society, 義守大學燕巢分部: 義守大學燕巢分部生物科技學系, 2009-12-04 ~ 2009-12-06.
  16. Ying-Ting Chen陳胤廷 , Tzu Ting Chang, Chaochin Su, Wen-Shan Li李文山, 2009, “Synthesis of Asp-lithocholic Acids Analogues and Their Impacts in Antimetastasis Effect”, paper presented at 2009 Annual Meeting of Chinese Chemical Society, 義守大學燕巢分部: 義守大學燕巢分部生物科技學系, 2009-12-04 ~ 2009-12-06.
  17. Chen, Hsi-Hsun陳錫勳, Li, Wen-Shan李文山*, 2009, “Artificial Hydrolase Mimics, 1,2,3-Triazole-Based Metal Complexes, for Hydrolysis of Organophosphate Pesticides”, paper presented at 2009 Annual Meeting of Chinese Chemical Society, 義守大學燕巢分部: 義守大學燕巢分部生物科技學系, 2009-12-04 ~ 2009-12-06.
  18. Hui-Chuan Chang1, Tzu-Ting Chang, Shu-Chuan Jao, Cheng Heng Wu,Wen-Shan Li, 2009, “Chemical rescue of proton relay system in an inactive mutant of human cytosolic aminopeptidase P”, paper presented at The 3rd International Symposium on Bio-Inspired Engineering (ISBIE), Academia Sinica: Academia Sinica, 2009-10-21 ~ 2009-10-23.
Science Report
  1. 李文山,2013,〈科學研究的誠信問題〉,《科學月刊》,頁521, 324-327.。
  2. 李文山,2007,〈探討酵素的新功能〉,《2007生物技術產業年鑑, 產業論壇》,頁 1-16.。
  3. Li, W. –S,2005,〈Enzymatic detoxification and bioremediation〉,《Natural Science Newsletter, National Science Council》,頁17 (2), 46-49.。
Others
  1. Li, W. –S.; Wang, Y. –C.; Juan H. –F. , 2008, “Preparation of l ithocholic acid analogs that inhibit sialyltransferase”, U.S. Pat. Appl. Publ., 35pp.