利用NMR光譜代替MRI快速評估引信響應的MRI顯影劑對比增益
A Facile NMR Method for Pre-MRI Evaluation of Trigger-Responsive T1 Contrast EnhancementSmall Methods 2024, 2301603
Cheng-Bang Jian, Ying-Yann Wu, Ming-Huang Lin, Hua-De Gao, Chong-Yan Chen, Shwee Khuan Leong, Der-Lii M. Tzou, Dennis W. Hwang*, Hsien-Ming Lee*
Smart MRI contrast agents, which respond to disease-specific chemical or biochemical signals, hold significant clinical importance. However, the inaccessibility of MRI instruments for chemists greatly slows down research and development. To increase the experimental turnover rate, it is essential to use NMR as a substitute for MRI in evaluating smart MRI contrast changes during the development stage. This manuscript presents a straightforward method for chemists to quantify smart contrast T1 signal changes using NMR, significantly reducing the long wait times associated with MRI during the development phase.
智能MRI顯影劑能對疾病特定的化學或生化信號作出影像對比，具有極重要的臨床應用，例如早期癌症診斷，但尚在發展階段。然而，對於化學家來說，要加入此項研究，MRI儀器預約及使用的不方便性及不可觸及性，大大減慢了研究和開發的速度。為了提高實驗的周轉率，必須在開發階段使用NMR替代MRI來評估發展階段MRI顯影劑的引信響應變化，來優化設計。這篇論文介紹了一種簡便的方法，讓化學家能夠輕易且快速的使用NMR，來量化智能顯影劑T1信號的引信響應變化，顯著縮短了開發階段MRI漫長的反覆等待時間。