Fig. 1. We developed a PROTAC molecule that selectively degrades mutant huntingtin aggregates and alleviates disease phenotypes in Huntington‘s disease mouse models.
Nat. Comm. 2024, 15, 5686-5698
Fig. 2. We designed a photocontrollable droplet-forming peptide (JSF1) that modulates FUS protein phase behavior by enhancing condensation in the dark and inducing fibril formation upon light activation.
Adv. Sci. 2020, 7, 1901165
Fig. 3. We created amphiphilic peptide that can be transported to the brain and rescue the memory deficit through intranasal administration. The related patents have been approved in Taiwan and United States.
ACS Nano 2017, 11(7), 6795-6807
Fig. 4. We established a photocontrollable platform to trigger amyloidogenesis to recapitulate the pathogenesis of ALS by applying a chemically-engineered probe.
J. Am. Chem. Soc. 2010, 132, 1186-1187
Fig. 5. We induced the first amyloid fibers from the C-terminal peptide fragments of TDP-43 protein in ALS.
"The 2019 Career Development Award (中研院前瞻計畫)" (2019)
"Award received from the Taiwan Motor Neuron Disease Association(第三屆漸凍人研究獎)" (2018)
"Ministry of Science and Technology Research Project for Excellent Young Scholars(科技部優秀年輕學者研究計畫)" (2017)
"2012 Excellent Young Scholar Award (2012年中國化學會傑出青年化學獎章)" (2012-12)
He, R.-Y.; Lai, X.-M.; Sun, C. -S; Kung, T.-S.; Hong, J.-Y.; Jheng, Y.-S.; Liao, W. -N.; Chen, J. -K.; Liao, Y. -F.; Tu, P. -H.; Huang, J. J. -T. Nanoscopic insights of amphiphilic peptide against oligomer assembly process to treat Huntington’s disease. Adv. Sci.2020, 7, 1901165.
Wahyuningtyas, D.; Chen, W.-H.; Huang, C.-H.; He, Y.-J.; Huang, J.J-T. Biocompatible Inhibitor Based on Chitosan and Amphiphilic Peptide against Mutant Huntingtin Toxicity. ChemBioChem2019, 20, 2133-2140. (Cover Article)
He, R.-Y.; Huang, Y.-C.; Chiang, C.-W.; Tsai, Y.-J.; Ye, T.-J.; Gao, H.-D.; Wu, C.-Y.; Lee, Y.-M.; Huang, J. J.-T. Characterization and real-time imaging of the FTLD-related protein aggregation induced by amyloidogenic peptides. Chem. Commun. 2015, 51, 8652.
Sun, C.-S. ; Lee, C.-C.; Li, Y-N; Yang S. Y.-C.; Lin, C.-H.; Chang, Y.-C.; He, R.-Y.; Liu, P.-F.; Wang ,C.-H.; Chen, W.; Chern, Y.; Huang J. J.-T. Conformational switch of polyglutamine-expanded huntingtin into benign aggregates leads to neuroprotective effect. Sci. Rep. 2015, 5, 14992. (Recommended in F1000Prime by F1000 faculty member)
Huang C.-C.; Bose J.-K.; Majumder P.; Lee K.-H., Huang, J. J.-T.; Huang J. K.; Shen J. C.-K. Metabolism and mis-metabolism of the neuropathological signature protein TDP-43. J. Cell Sci.2014, 127(Pt 14), 3024..
Liu, G. C.-H.; Chen, B. P.-W.; Ye, N. T.-J.; Wang, C.-H.; Chen, W.; Lee, H.-M.; Chan, S. I., Huang, J. J.-T. Delineating the membrane-disrupting and seeding properties of the TDP-43 amyloidogenic core. Chem. Commun.2013, 49, 11212. (Highlighted in Significant Research Achievements of Academia Sinica 2013)
Huang, J. J.-T.; Larsen, R.-W.; Chan, S.-I. The Interplay of Turn Formation and Hydrophobic Interactions on the Early Kinetic Events in Protein Folding. Chem. Comm. 2012, (Feature Article), 48, 487.
Chen, K.-H.; Lin, Y.-Y.; Xie, Z.-J.; Tu, P.-H.; Chen, P.-Y.; Liao, T.-Y.; Huang, J. J.-T. Induction of Amyloid Fibrils by the C-terminal Fragments of TDP-43 in Amyotrophic Lateral Sclerosis. J. Am. Chem. Soc. 2010, 132, 1186. (Highlighted in Significant Research Achievements of Academia Sinica 2010) (Selected in 2010 Science and Technology Yearbook of Republic of China)
Kuo, N. N.-W.; Huang, J. J.-T.; Miksovska, J.; Chen, P.-Y.; Larsen, R.; Chan, S. I. Effects of turn stability on the kinetics of refolding of a hairpin in b-sheet. J. Am. Chem. Soc. 2005, 127, 16945.
Chen, R. P. Y.; Huang, J. J.-T.;Chen, H. L.; Jan, H.; Velusamy, M.; Lee, C. T.; Fann, W. S.; Larsen, R. W.; Chan, S. I. Measuring the refolding of beta-sheets with different turn sequences on a nanosecond time scale. Proc. Natl. Acad. Sci. U. S. A. 2004, 101, 7305.
BOOK CHAPTER:
Chan, S. I.; Huang, J. J.-T.; Larsen, R. W.; Rock, R. S.; Hansen, K. C. Early kinetic events in protein folding: The development and applications of caged peptides in dynamic studies in biology. phototriggers, photoswitches, and caged biomolecules; Goeldner, M. and Givens. R. (eds), Wiley-VCH GmbH & Co. Germany, 2005, pp479.
Update：
2026-03-19
Lu, P.-C.; Huang, Y.-A.; Niaz Wali.; Tseng, M.-C.; He, R.-Y.; Chern, Yijuang.; Wei, T.-T.; Shie, J.-J.;* and Huang, J. J.-T.* PROTAC-Mediated Degradation of mHTT Aggregates Attenuates Neurotoxicity in Cellular and R6/2 Mouse Models of Huntington’s Disease. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY2026-02-19, 148,8.
Wahyuningtyas, D.; Yu, Yoyo. C.-T.; Hsieh, C.-Y.; Huang, Y.-A.; He, R.-Y.; Teng, T.-H.; Chen, B. P.-W.; Huang, J.-R.; Wu, David; and Huang, J. J.-T.* Self-Assembled Hydrogel from Pyrene-Modified Peptide as 3D 2 Matrices for Neuronal Cell. ACS Applied Bio Materials2026, 9, 800-812.
Chen, B. P.-W.; Hsu, C.-P.; Huang, J. J.-T.*; and Chou, P.-T.* Crystal Packing–Trajectory Correlation in Topochemical Photoisomerization. Angew. Chem. Int. Ed.2026, 65, e18997.
Chen, B. P.-W.; Lee, C.-C.; He, R.-Y.; Huang, A.-C.; Huang, J.-R.; Chan, Jerry C.-C.; * and Huang, J. J.-T.* Amyloidogenic oligomers derived from TDP-43 LCD promote the condensation and phosphorylation of TDP-43. Chemical Science2025, 17, 1210-1222.
Tsai, M.-S.; Lee, Mandy M.; Li, S-R.; He, R.-Y.; Ashutosh S. Singh.; Huang, J. J.-T.; Chang K.-C.; Sun S.-S. Nano-sized toroids and lemniscates assembled from self-organization of a C3-symmetry organogelator.. J Chin Chem Soc.2025, 72, 1136-1144.
Diksha Agnihotri; Lee ,C.-C.; Lu, P.-C.; He, R.-Y.; Huang, Y.-A.; Kuo, H.-C.; Huang, J. J.-T.* C9ORF72 poly-PR induces TDP-43 nuclear condensation via NEAT1 and is modulated by HSP70 activity. Cell Reports2025, 44(1), 115173.
Liu, Y.-J.; Lee, C.-W.; Liao, Y.-C.; Huang, J. J.-T., Kuo, H.-C.; Jih, K.-Y.; Lee, Y.-C.; Chern, Yijuang* The role of adiponectin-AMPK axis in TDP-43 mislocalization and disease severity in ALS. Neurobiology of Disease2024-11, 202, 106715.
Chuang, H.-Y.; He, R.-Y.; Huang, Y.-A.; Hsu, W.-T.; Cheng, Y.-J.; Guo, Z.-R.; Niaz Wali, Hwang, I-S.; Shie, J.-J.; Huang, J. J.-T.* Engineered droplet-forming peptide as photocontrollable phase modulator for fused in sarcoma protein. Nature Communications2024, 15(1), 5686-5698.
Tseng, Y.-L.; Lu, P.-C.; Lee, C.-C.; He, R.-Y.; Huang, Y.-A.; Tseng, Y.-C.; Cheng, R. T.-J.; Huang, J. J.-T.*; Fang, J.-M.* Degradation of neurodegenerative disease-associated TDP-43 aggregates and oligomers via a proteolysis-targeting chimera. JOURNAL OF BIOMEDICAL SCIENCE2023, 30(1), 27.
Chen, B. P.-W.; He, R.-Y.; Chien, H.-M.; Lee, C.-C.; Hsu, C.-P.; Chan, J. C.-C.; Huang, J. J.-T.* Superresolution Imaging of Photochromic Acylhydrazone Moieties on Amyloid Nanofibrils: Implications for Photoswitchable Probes.. ACS APPLIED NANO MATERIALS2022-01, 5(2), 1734-1739.
Chien, H.-M.; He, R.-Y.; Lee, C.-C.; Huang, Y.-A.; Hung, I.-J.; Hou, K.-T.; Hsiao, J.-C.; Lu, P.-C.; Agnihotri, D.; Hwang, E.; Huang, J. J.-T.* Nanoscopic investigation of C9orf72 poly-GA oligomers on nuclear membrane disruption by photoinducible platform. Communications Chemistry2021-07, 4(111), 1-13.
Chien, H.-M.; Lee, C.-C.; Huang, J. J.-T.* The Different Faces of the TDP-43 Low-Complexity Domain: The Formation of Liquid Droplets and Amyloid Fibrils. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES2021-07, 22(15), 8213.
He, R.-Y.; Lai, X.-M.; Sun, C.-S; Kung, T.-S.; Hong, J.-Y.; Jheng, Y.-S.; Liao, W.-N.; Chen, J.-K.; Liao, Y.-F.; Tu, P.-H.*; Huang, J. J.-T.* Nanoscopic insights of amphiphilic peptide against oligomer assembly process to treat Huntington’s disease. ADVANCED SCIENCE2019-09, 1901165 (1 of 13), 1901165 (1 of 13).
Lee, C.-C.; He, R.-Y.; Huang, J. J.-T.* Learning from the TDP-43 amyloidogenic sequences in neurodegenerative diseases. AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS2019-07-25, 26(sup1), 154-155.
Wahyuningtyas, D.; Chen, W.-H.; Huang, C.-H.; He, Y.-J.; Huang, J. J.-T.* Biocompatible Inhibitor Based on Chitosan and Amphiphilic Peptide against Mutant Huntingtin Toxicity. CHEMBIOCHEM2019-06, 20, 2133-2140.
Koubek, J.; Chang, Y.-C.; Yang, S.Y.-C.; Huang, J. J.-T.* Trigger factor-induced nascent chain dynamics changes suggest two different chaperone-nascent chain interactions during translation. JOURNAL OF MOLECULAR BIOLOGY2017-07, 429, 1733-1745.
Du, Y.-P.; Chang, H.-H.; Yang, S.-Y.; Huang, S.-J.; Tsai, Y.-J.; Huang, J .J-T.; Chan, J.-C.* Study of Binding Interaction between Pif80 Protein Fragment and Aragonite. SCIENTIFIC REPORTS2016, 6, 30883.
Chen, C.-H.; Khan, A.; Huang, J. J.-T.; Ulmschneider, M.-B.* Mechanisms of membrane-pore formation by amyloidogenic peptides in ALS. CHEMISTRY-A EUROPEAN JOURNAL2016, 22, 9958-9961.
Sun, C.-S. , Lee, C.-C., Li, Y-N, Yang S. Y.-C., Lin, C.-H., Chang, Y.-C., He, R.-Y. , Liu, P.-F., Wang ,C.-H., Chen, W. , Chern, Y., Huang, J. J.-T.* Conformational switch of polyglutamine-expanded huntingtin into benign aggregates leads to neuroprotective effect.. Scientific Reports2015, 5,14992.
Koubek, J., Chen, Y.-R., Cheng, R.-P.,Huang, J.J.-T.* Nonorthogonal tRNA(cys, Amber) for protein and nascent chain labeling. RNA2015, 21,1672-1682.
He, R.-Y., Huang, Y.-C., Chiang, C.-W., Tsai, Y.-J., Ye, T.-J., Gao, H.-D., Wu, C.-Y., Lee, Y.-M., Huang, J.J.-T.* Characterization and real-time imaging of the FTLD-related protein aggregation induced by amyloidogenic peptides. CHEMICAL COMMUNICATIONS2015, 51, 8652-8655.
Huang, C.-C., Bose, J.-K., Majumder, P., Lee, K.-H., Huang, J. J.-T., Huang, J.-K., Shen, C.-K.*. Metabolism and mis-metabolism of the neuropathological signature protein TDP-43. Journal of cell science2014, 127(Pt 14), 3024-38.
Sun, C.-S., Wang, C.-Y., Chen, B.-P., He, R.-Y., Liu, G. C.-H., Wang, C.-H., Chen, W., Chern. Y., Huang, J. J.-T.* The Influence of Pathological Mutations and Proline Substitutions in TDP-43 Glycine-Rich Peptides on Its Amyloid Properties and Cellular Toxicity. PloS one2014, 9(8), e103644.
Liu, G. C.-H., Chen, B. P.-W, Ye, N. T.-J., Wang, C.-H., Chen, W., Lee, H.-M., Chan, S.-I., Huang, J.J.-T.* Delineating the membrane-disrupting and seeding properties of the TDP-43 amyloidogenic core. CHEMICAL COMMUNICATIONS2013-10, 49(95), 11212-4.
Koubek, J., Lin, K.-F., Chen, Y.-R., Cheng, R.-P., Huang, J. J.-T.* Strong anion exchange fast performance liquid chromatography as a versatile tool for preparation and purification of RNA produced by in vitro transcription. RNA2013-06, 19,1449-1459.
Huang, Y.-C. Lin, K.-F., He, R.-Y., Tu, P.-H. Koubek, J., Hsu,Y.-C., Huang, J. J.-T.* Inhibition of TDP-43 aggregation by nucleic acid binding. PLoS One2013-05, 8(5), e64002.
Chang, C.-K., Wu, T.-H., Wu, C.-Y., Chiang, M.-H., Toh, E.-K., Hsu, Y.-C., Lin, K.-F., Liao, Y.-H., Huang, T.-H.*, Huang, J. J.-T.* The N-terminus of TDP-43 Promotes Its Oligomerization and Enhances DNA Binding Affinity.. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS2012, 425(2), 219-224.
Lin, K.-F., Sun, C.-S., Huang, Y.-C., Chan, S.-I., Koubek, J., Wu, T.-H., Huang, J. J.-T.* Cotranslational Protein Folding within the Ribosome Tunnel Influences Trigger-Factor Recruitment. BIOPHYSICAL JOURNAL2012, 102, 2818-2827.
Huang, J. J.-T., Larsen, R.-W., Chan, S.-I.* The Interplay of Turn Formation and Hydrophobic Interactions on the Early Kinetic Events in Protein Folding. CHEMICAL COMMUNICATIONS2012, 48, 487-497.
Allan K.-H. Chen, Ryan Y.-Y. Lin, Eva Z.-J. Hsieh, Pang-Hsien Tu, Rita P.-Y. Chen,Tai-Yan Liao, Wenlung Chen, Chih-Hsien Wang, and Joseph J.-T. Huang* Induction of Amyloid Fibrils by the C-Terminal Fragments of TDP-43 in Amyotrophic Lateral Sclerosis. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY2010, 132,1186-1187.
Jih Ru Hwu,*Joseph Jen-Tse Huang,Fu-Yuan Tsai,Shwu-Chen Tsay,Ming-Hua Hsu,Kuo Chu Hwang,Jia-Cherng Horng,Ja-an Annie Ho,Chun-Cheng Lin Photochemical Activities of N-Nitroso Carboxamides and Sulfoximides as well as Their Application to DNA Cleavage. CHEMISTRY-A EUROPEAN JOURNAL2009, 15, 8742-8750.
Huang, J. J.-T.*, Jhan, J.-W. Ultra-fast and Cotranslational Protein Folding. Natural Sciences Newsletter2008, 20,50-53.
Kirchdoerfer RN, Huang JJ, Isola MK, Cavagnero S Fluorescence-based analysis of aminoacyl- and peptidyl-tRNA by low-pH sodium dodecyl sulfate-polyacrylamide gel electrophoresis. ANALYTICAL BIOCHEMISTRY2007, 364(1), 92-4.
Kuo NN, Huang JJ, Miksovska J, Chen RP, Larsen RW, Chan SI Effects of turn stability on the kinetics of refolding of a hairpin in a beta-sheet. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY2005, 127(48), 16945-54.
Chen RP, Huang JJ, Chen HL, Jan H, Velusamy M, Lee CT, Fann W, Larsen RW, Chan SI Measuring the refolding of beta-sheets with different turn sequences on a nanosecond time scale. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA2004, 101(19), 7305-10.
Chan, S. I.*, Huang, J. J.-T., Larsen, R. W., Rock, R. S., Hansen, K. C., 2005, “Early kinetic events in protein folding: The development and applications of caged peptides.”, editor(s): Goeldner, M., Givens. R., Dynamic Studies in Biology: Phototriggers, Photoswitches and Caged Biomolecules, pp. 479-494, Germany: Wiley-VCH GmbH & Co..
Jen-Tse Huang*, 2018, “Identify amyloidogenic peptides in TDP-43 and create photocontrollable probes for neurodegenerative disease”, paper presented at The 10th International Peptide Symposium, Japan: The Liaison Committee of International Peptide Societies,, 2018-12-03 ~ 2018-12-07.
Jen-Tse Huang*, 2018, “Learning from the Amyloidogenic Peptides in Amyotrophic Lateral Sclerosis ”, paper presented at The XVIth International Symposium on Amyloidosis, Kumamoto, Japan: ISA2018 program, 2018-05-26 ~ 2018-05-29.
Jen-Tse Huang*, 2017, “Photo-Controllable Probe Spatiotemporally Induces Neurotoxic Aggregates in Neurodegenerative Disease”, paper presented at BIT’s 7th Annual World Congress of Nano Science & Technology-2017, Fukuoka, Japan: World High Technology Society (WHTS), 2017-10-24 ~ 2017-10-26.
Jen-Tse Huang*, 2016, “Amyloidogenic Peptides and Proteins inNeurodegenerative Diseases”, paper presented at 2016 ITbM-IoC Joint Workshop on Biomolecules and Materials, Nagoya University, Nagoya, Japan: Institute of Transformative Bio-Molecules Nagoya University, 2016-11-15 ~ 2016-11-17.
Jen-Tse Huang*, 2016, “Learning from the Amyloidogenic Peptides in the Neurodegenerative Diseases”, paper presented at KAUST-NTU-AS Workshop for Enhancing collaborations on Research and Education in Chemical and Materials Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal/Saudi Arabia: King Abdullah University of Science and Technology, KAUST, 2016-04-01 ~ 2016-04-08.
Jen-Tse Huang*, 2015, “ALS and FTLD-related protein aggregation induced by amyloidogenic peptides”, paper presented at PACIFICHEM 2015, Honolulu, Hawaii, USA: The International Chemical Congress of Pacific Basin Societies, 2015-12-15 ~ 2015-12-20.
VJ,Joseph J.-T. Huang*, 2015, “Early recognition by SecA targets secretory protein near the ribosome exit tunnel”, paper presented at Protein synthesis and translational control, Germany: The European Molecular Biology Laboratory, 2015-09-09 ~ 2015-09-13.
Koubek J,Joseph J.-T. Huang*, 2015, “The local and global effects of DnaK and Trigger Factor on ribosome-bound nascent chain dynamics”, paper presented at Molecular chaperones: From molecules to cells and misfolding diseases, Greece: EMBO Conference, 2015-05-08 ~ 2015-05-13.
Jen-Tse Huang*, 2015, “From pathological to therapeutic peptides in neurodegenerative diseases”, paper presented at 分子科學前沿海峽兩岸交流會, 北京中國科學院化學研究所: 中國科學院化學研究所, 2015-04-24 ~ 2015-04-27.
Joseph Jen-Tse Huang, 2014, “The amyloid and prion-like properties of the TDP-43 peptides in Amyotrophic Lateal Sclerosis”, paper presented at The 2nd Taiwan-Tohoku University Neuroscience Workshop for Young Scientists, Japan: The 2nd Taiwan-Tohoku University Neuroscience Workshop for Young Scientists, 2014-12-07 ~ 2014-12-10.
He Ruei-Yu,Jen-Tse Huang*, 2014, “Synthetic Gluntamine/Asparagine-rich polypeptides from TDP-43 exhibit amyloid properties and induce prion-like aggregation in amyotrophic lateral scelerosis”, paper presented at The 2nd Taiwan-Tohoku University Neuroscience Workshop for Young Scientists, Japan: Taiwan-Tohoku University Neuroscience Workshop for Young Scientists, 2014-12-07 ~ 2014-12-10.
Koubek J,Joseph J.-T. Huang*, 2014, “Development of cysteine-specific tRNA and tRNA synthetase for site-specific protein fluorescence labeling in co-translational protein folding studies”, paper presented at 25th tRNA Conference, Greece: Society of Biochemistry and Molecular Biology, the University of Patras, 2014-09-21 ~ 2014-09-25.
Chia-Sui Sun, Yijuang Chern, Joseph J.-T. Huang*, 2014, “The modulation of FKBP12 on the mutant Huntintin-induced neurotoxicity and aggregation”, paper presented at The 19th Annual Conference of the Biophysical Society of ROC, National Chen Kung University, Tainan, Taiwan: Biophysical Society of R.O.C.Institute of Bioinformatics and Biosignal Transduction, CBB, National Chen-Kung University, 2014-05-07 ~ 2014-05-10.
Gerard, Chun-Hao Liu, Bryan, Po-Wen Chen, Nancy, Ting-Juan Ye, Chih-Hsien Wang, Wenlung Chen, Hsien-Ming Lee, Sunney I. Chan, Joseph, Jen-Tse Huang*, 2014, “Delineating the membrane-disrupting and seeding properties of the TDP-43 amyloidogenic core”, paper presented at The 19th Annual Conference of the Biophysical Society of ROC, National Chen Kung University, Tainan, Taiwan: Biophysical Society of R.O.C.Institute of Bioinformatics and Biosignal Transduction, CBB, National Chen-Kung University, 2014-05-07 ~ 2014-05-10.
Huang, J. J.-T.*, 2013, “From pathological to therapeutic peptides”, paper presented at The Hebrew University of Jerusalem, Israel - Academia Sinica Bilateral Workshop on Nanoscience and Nanotechnology, The Auditorium, 1F, Institute of Physics, Academia Sinica: Academia Sinica Research Program on Nanoscience and Nanotechnology, 2013-11-15.
Huang, J. J.-T.*, 2013, “The Impact of co-Translational Protein Folding within the Ribosome Tunnel on Chaperone Recruiitment”, paper presented at Technologies for Medical Diagnosis and Therapy Symposium, B1 Auditorium, Inst. of Biomedical Sciences, Academia Sinica: Institute of Biomedical Sciences Academia Sinica, 2013-10-21 ~ 2013-10-22.
Hsu, Y.-C., Lin, K.-F., Huang, J. J.-T*, 2013, “Characterization of the thermal induced fiber from TDP-43 and its association with single-stranded DNA”, 83 pages, paper presented at The 18th Biophysics Conference, Institute of BioMedical Sciences, Academia Sinica: Biophysical Society of R.O.C、IBMS, Academia Sinica, 2013-06-27 ~ 2013-06-29.
Li, Y.-N., Sun, C.-S., Wu. C.-Y., Huang. J. J.-T.*, 2013, “Modulate polyglutamin protein aggregation by Trigger factor and FKBP12”, 79 pages, paper presented at The 18th Biophysics Conference, Institute of BioMedical Sciences, Academia Sinica: Biophysical Society of R.O.C、IBMS, Academia Sinica, 2013-06-27 ~ 2013-06-29.
Vijayasarathy.K, Hsu Yin-Chih, Jiri Koubek, Joseph J.-T. Huang*, 2013, “Structure characterization of ATPase-chaperone-preprotein recognition in the secretory pathway”, 84 pages, paper presented at The 18th Biophysics Conference, Institute of BioMedical Sciences, Academia Sinica: Biophysical Society of R.O.C、IBMS, Academia Sinica, 2013-06-27 ~ 2013-06-29.
Chang, C.-K., Chiang, M.-H., Wu, T.-H., Toh, E. K.-W., Huang, J. J.-T., Huang, T.-H.*, 2013, “Directional binding of nucleic acid to TAR DNA-binding protein (TDP-43) RRM1 domain provides insight into splicing regulation”, 69 pages, paper presented at The 18th Biophysics Conference, Institute of BioMedical Sciences, Academia Sinica: Biophysical Society of R.O.C、IBMS, Academia Sinica, 2013-06-27 ~ 2013-06-29.
Huang, Y.-C., Lin, K.-F., He, R.-Y., Tu, P.-H. Koubek, J., Hsu,Y.-C., Huang, J. J.-T.* , 2013, “Inhibition of TDP-43 aggregation by nucleic acid binding”, 77 pages, paper presented at The 18th Biophysics Conference, Institute of BioMedical Sciences, Academia Sinica: Biophysical Society of R.O.C、IBMS, Academia Sinica, 2013-06-27 ~ 2013-06-29.
Wu, T.-H., Chang, C.-K., Wu, C.-Y. Hsu, Y.-C., Huang, T.-H., Huang, J. J.-T.*, 2013, “C-terminal aggregation-prone domain of neurodegenerative TDP-43 is required for altering ssDNA/RNA structure”, paper presented at The 18th Biophysics Conference, Institute of BioMedical Sciences, Academia Sinica: Biophysical Society of R.O.C、IBMS, Academia Sinica, 2013-06-27 ~ 2013-06-29.
Huang, J. J.-T.*, 2013, “Complementary paradigm and insight towardmodulating TDP-43 aggregation via nucleic acid binding”, paper presented at Institute for Protein Research Seminar 2013, Osaka, Japan: Institute for Protein Research, 2013-06-19 ~ 2013-06-20.
Jen-Tse Huang*, 2013, “The different faces of the intrinsically disordered TDP-43 in Amyotrophic Lateral Sclerosis”, paper presented at Academia Sinica and UC Davis Neuroscience Symposium, University of california, San Francisco: UC Davis Neuroscience ,NPAS, 2013-04-22 ~ 2013-04-24.
Yi-Ni Li , Chia-Sui Sun , Chu-Ya Wu , Joseph J.-T. Huang* , 2012, “The influence of molecular chaperones on the mHtt protein aggregation process”, paper presented at 2012 Annual Meeting of Chemical Society, Department of Chemistry, National Cheng-Kung University: Department of Chemistry, National Cheng-Kung University, 2012-12-01 ~ 2012-12-02.
Yi-Chen Huang, Jen-Tse Huang*, 2012, “Exploring the roles of DNA/RNA on TDP-43 aggregation in Amyotrophic Lateral Sclerosis”, 64 pages, paper presented at The 12th Annual Meeting of the Protein Science Society of Japan, Nagoya, Japan: Protein Science Society of Japan, 2012-06-20 ~ 2012-06-23.
Jen-Tse Huang* , 2012, “Co-translational Protein Folding: The Journey from the Ribosome Tunnel to Cellular Function”, 71 pages, paper presented at The 12th Annual Meeting of the Protein Science Society of Japan, Nagoya, Japan: Protein Science Society of Japan, 2012-06-20 ~ 2012-06-23.
Ku-Feng Lin, Joseph Jen-Tse Huang* , 2012, “Co-translational protein folding within the ribosome tunnel influences trigger-factor recruitment”, paper presented at The 17th Biophysics Conference, Institute of BioMedical Sciences, Academia Sinica: Biophysical Society of R.O.C、IBMS, Academia Sinica, 2012-05-23 ~ 2012-05-25.
Joseph Jen-Tse Huang, 2012, “The impact of mutations in TDP-43 fragments on the formation of amyloid fibers and cellular toxicity”, paper presented at The 17th Biophysics Conference, Institute of BioMedical Sciences, Academia Sinica: Biophysical Society of R.O.C、IBMS, Academia Sinica, 2012-05-23 ~ 2012-05-25.
Liu, G. C.-H., Huang, J. J-T.*, 2012, “Characterization of the aggregation properties of amyloid core in the TDP-43 C-terminal fragments”, paper presented at The 17th Biophysics Conference, Institute of BioMedical Sciences, Academia Sinica: Biophysical Society of R.O.C、IBMS, Academia Sinica, 2012-05-23 ~ 2012-05-25.
Joseph Jen-Tse Huang*, 2012, “Exploring the Co-translational Protein Folding Process with Novel Biophysical and Chemical Approaches”, paper presented at Frontiers in Chemistry-A symposium dedicated to the memory of Prof. Ta-shue Chou, 中央研究院化學所周大紓講堂: 中央研究院化學所, 2012-02-21.
Huang, J.-T., 2011, “Applying Novel Biophysical and Chemical Approaches in Co-translational Protein Folding Studies”, paper presented at 2011Annual Meeting of Chemical Society, National Tsing Hua University, Hsinchu: National Tsing Hua University, 2011-12-03 ~ 2011-12-04.
Chia-Sui Sun, Ruei-Yu He, Yijuang Chern, Joseph J.-T. Huang*, 2011, “Characterize the aggregation process of the mHtt protein in the presence of chaperone”, paper presented at France-Taiwanesse Symposium on Neurobiology, IGBMC, France: IGBMC, 2011-11-28 ~ 2011-11-29.
Huang, J.-T., 2011, “The Discovery of the Amyloid Fibrils from the C-terminal Fragments of TDP-43 in Amyotrophic Lateral Sclerosis”, paper presented at The 1st International Kyoto Conference on Organic Nanostructures, Kyoto University, Kyoto, Japan: Kyoto University, 2011-11-10.
Huang, J.-T., 2011, “The Discovery of the Amyloid Fibrils from the C-terminal Fragments of TDP-43 in Amyotrophic Lateral Sclerosis”, paper presented at The 11th Tateshina Conference on Organic Chemistry, Nagoya, Japan: The 11th Tateshina Conference on Organic Chemistry, 2011-11-11 ~ 2011-11-13.
Huang, J.-T., 2011, “Light up the folding zone within the ribosome tunnel”, paper presented at Sunney Chan Symposium 2011, Chou Ta-Shue Lecture Hall, Institute of Chemistry, Academia Sini: Institute of Chemistry, Academia Sinica, 2011-10-05.
Huang, J.-T., 2011, “The impact of co-translational protein folding within the ribosome tunnel on chaperone recruitment”, paper presented at The 16th Biophysics Conference, National Dong Hwa University, Hua Lien: Biophysical Society of Taiwan R.O.C, 2011-05-18 ~ 2011-05-21.
Huang, J.-T., 2010, “ Induction of amyloid fibrils by the TDP-43 fragments in ALS”, paper presented at 2010 Pacifichem Symposium, Honolulu, Hawaii, USA: Hawaii, USA, 2010-12-15 ~ 2010-12-20.
Huang, J.-T., 2010, “ Explore the impact of ribosome tunnel on co-translational protein folding and chaperone recruitment”, paper presented at 2010 Annual meeting of Chinese Society, 台北: 台灣大學, 2010-12-04 ~ 2010-12-05.
Joseph Jen-Tse Huang, 2009, “The Induction of TDP-43 C-terminal Fragment into Amyloid Fibrils by G294A Mutation in Amyotrophic Lateral Sclerosis”, p27 pages, paper presented at Frontier of Protein Aggregation and Neurodegenerative Diseases, 中央研究院生物化學研究所: 中央研究院生物化學研究所、中央研究院生物醫學研究所、中央研究院細胞與個體生物學研究所、中央研究院化學研究所、中央研究院基因體中心、中央研究院分子生物研究所, 2009-06-04.
Ku-Feng Lin, Chia-Sui Sun, and Joseph Jen-Tse Huang* , 2009, “Study on Cotranslational Protein Folding within the Ribosomal Exit Tunnel”, paper presented at Joint International Conference of Biophysics and 14th Annual Conference of the Biophysical Society of ROC, 國立成功大學: Biophysical Society of ROC, 2009-06-24 ~ 2009-06-27.
Allan K.-H. Chen, Ryan Y.-Y. Lin, Eva Z.-J. Xie, and Joseph J.-T. Huang*, 2009, “Mutation in TDP-43 C-terminal Fragment can Induce Beta-Amyloid Fibril Formation”, paper presented at Joint International Conference of Biophysics and 14th Annual Conference of the Biophysical Society of ROC, 國立成功大學: Biophysical Society of ROC, 2009-06-24 ~ 2009-06-27.
