PhD in Chemistry, University of California Berkeley (2008-2013); MS in Chemistry, National Taiwan University (2003-2005); BS in Applied Chemistry, National Chiao Tung University (1999-2003);Postdoctoral researcher: IME, University of Chicago (2016-2017, lab relocation from ETH); D-BSSE, ETH Zurich (2014-2016, EMBO Long-term Postdoc Fellow); QB3, University of California Berkeley (2013-2014).
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Christensen, S.*; Tu, H.-L.*; Jun, J.*; Alvarez, S.; Triplet, M.; Iwig, J.; Yadav, K.; Bar-Sagi, D.; Roose, J.; Groves, J. One-way membrane trafficking of SOS in receptor- triggered Ras activation. Nat. Struct. Mol. Biol.2016, 23, 838. (*: equal contribution).
Huang, W. Y.-C.; Yan, Q.; Lin, W.-C.; Chung, J.; Hansen, S.; Christensen, S.; Tu, H.-L.; Kuriyan, J.; Groves, J. Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS. Proc. Natl. Acad. Sci. 2016, 113, 8218.
Christensen, S.; Triplet, M.; Rhodes, C.; Iwig, J.; Tu, H.-L.; Stamou, D.; Groveset, J. Monitoring the waiting time sequence of single Ras GTPase activation events using liposome functionalized zero mode waveguides. Nano Lett. 2016, 16, 2890.
Iversen, L.*; Tu, H.-L.* et al. Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics. Science2014, 345, 50. (*: equal contribution)
Lin, W.-C.*; Iversen, L.*; Tu, H.-L. et al. H-Ras forms dimers on membrane surfaces via a protein-protein interface. Proc. Natl. Acad. Sci. 2014, 111, 2996. (*: equal contribution)
Lohmüller, T.; Iversen, L.; Schmidt, M.; Rhodes, C.; Tu, H.-L.; Lin, W.-C.; Groves, J. Single molecule tracking on supported membranes with arrays of optical nanoantennas. Nano Lett. 2012, 12, 1717.
M. Son, A. Wang, H.-L. Tu, M. Metzig, P. Patel, K. Husain, J. Lin, A. Murugan, A. Hoffmann and S. Tay* NF-κB responds to absolute differences in cytokine concentrations. Science Signaling2021-01, 14 (666), eaaz4382.
Y. Li, J.-F. Xie, C.-C. Chang, C.-M. Wang* and H.-L. Tu* Highly Sensitive Detection of Mercury Ions Using Zincophosphite Framework Nanoparticle–Polyaniline Composites. ACS Applied Nano Materials2020-09, 3 (10), 9724–9730.
J. Hsieh, J.-Y. Chen, H.-Y. Li, H.-K. Liu, H.-L. Tu and C.-M. Wang* A thio-functionalized zinc phosphite with a large-channel framework and enhanced removal ability of mercury ion from aqueous solutions. Dalton Transactions2020-06, 49, 11085-11089.
U. Dhawan, W.‐L. Wang, B. Gautam, J. A. Janardhanan, P.‐C. Hsiao, H.‐L. Tu, H.‐H. Yu* Mechanotactic Activation of TGF‐β by PEDOT Artificial Microenvironments Triggers Epithelial to Mesenchymal Transition. Advanced Biosystems2020-01, 4 (2), 1900165.
Lin Jing, Jordi Christian, Son Minjun, Van Phan Hoang, Drayman Nir, Abasiyanik Mustafa Fatih, Vistain Luke, Tu Hsiung-Lin, Tay Savaş Ultra-sensitive digital quantification of proteins and mRNA in single cells. Nature Communications2019-08, 10(1), 3544.
Zhang Ce, Tu Hsiung-Lin, Jia Gengjie, Mukhtar Tanzila, Taylor Verdon, Rzhetsky Andrey, Tay Savaş Ultra-multiplexed analysis of single-cell dynamics reveals logic rules in differentiation. Science Advances2019-04, 5(4), eaav7959.
Sune M. Christensen, Meredith G. Triplet, Christopher Rhodes, Jeffrey S. Iwig, Hsiung-Lin Tu, Dimitrios Stamou, Jay T. Groves Monitoring The Waiting Time Sequence of Single Ras GTPase Activation Events Using Liposome Functionalized Zero Mode Waveguides. NANO LETTERS2016, 16, 2890-2895.
William Y. C. Huang, Qingrong Yan, Wan-Chen Lin, Jean K. Chung, Scott D. Hansen, Sune M. Christensen, Hsiung-Lin Tu, John Kuriyan, Jay T. Groves Phosphotyrosine-mediated LAT Assembly on Membranes Drives Kinetic Bifurcation in Recruitment Dynamics of The Ras Activator SOS. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA2016, 113, 8218-8223.
Sune M Christensen, Hsiung-Lin Tu, Jesse E Jun, Steven Alvarez, Meredith G Triplet, Jeffrey S Iwig, Kamlesh K Yadav, Dafna Bar-Sagi, Jeroen P Roose, Jay T Groves One-way Membrane Trafficking of SOS in Receptor-Triggered Ras Activation. NATURE STRUCTURAL & MOLECULAR BIOLOGY2016, 23, 838-846.
Wan-Chen Lin, Lars Iversen, Hsiung-Lin Tu, Christopher Rhodes, Sune M. Christensen, Jeffrey S. Iwig, Scott D. Hansen, William Y. C. Huang, Jay T. Groves H-Ras Forms Dimers on Membrane Surfaces via A Protein-Protein Interface. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA2014, 111, 2996-3001.
Lars Iversen, Hsiung-Lin Tu, Wan-Chen Lin, Sune M. Christensen, Steven M. Abel, Jeff Iwig, Hung-Jen Wu, Jodi Gureasko, Christopher Rhodes, Rebecca S. Petit, Scott D. Hansen, Peter Thill, Cheng-Han Yu, Dimitrios Stamou, Arup K. Chakraborty, John Kuriyan, Ras Activation by SOS: Allosteric Regulation by Altered Fluctuation Dynamics. SCIENCE2014, 345, 50-54.
T. Lohmüller, L. Iversen, M. Schmidt, C. Rhodes, Hsiung-Lin Tu, W.-C. Lin, J. T. Groves Single Molecule Tracking on Supported Membranes with Arrays of Optical Nanoantennas. NANO LETTERS2012, 12, 1717-1721.