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Hsiung-Lin Tu (涂熊林)

Surface Physical and Materials Chemistry, Chemical and Systems Biology

Hsiung-Lin Tu (涂熊林)

researcherid:B-6814-2018     886-2-55728622
    886-2-27831237
    hltugate.sinica.edu.tw
    Hsiung-Lin Tu 's Lab
PhD in Chemistry, University of California Berkeley (2008-2013)； MS in Chemistry, National Taiwan University (2003-2005)； BS in Applied Chemistry, National Chiao Tung University (1999-2003)；Postdoctoral researcher: IME, University of Chicago (2016-2017, lab relocation from ETH)； D-BSSE, ETH Zurich (2014-2016, EMBO Long-term Postdoc Fellow)； QB3, University of California Berkeley (2013-2014). ；
Research Interests



Award & Honor
Selected Publications
  1. Christensen, S.*; Tu, H.-L.*; Jun, J.*; Alvarez, S.; Triplet, M.; Iwig, J.; Yadav, K.; Bar-Sagi, D.; Roose, J.; Groves, J. One-way membrane trafficking of SOS in receptor- triggered Ras activation. Nat. Struct. Mol. Biol. 2016, 23, 838. (*: equal contribution).
  2. Huang, W. Y.-C.; Yan, Q.; Lin, W.-C.; Chung, J.; Hansen, S.; Christensen, S.; Tu, H.-L.; Kuriyan, J.; Groves, J. Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS. Proc. Natl. Acad. Sci. 2016, 113, 8218.
  3. Christensen, S.; Triplet, M.; Rhodes, C.; Iwig, J.; Tu, H.-L.; Stamou, D.; Groveset, J. Monitoring the waiting time sequence of single Ras GTPase activation events using liposome functionalized zero mode waveguides. Nano Lett. 2016, 16, 2890.
  4. Iversen, L.*; Tu, H.-L.* et al. Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics. Science 2014, 345, 50. (*: equal contribution)
  5. Lin, W.-C.*; Iversen, L.*; Tu, H.-L. et al. H-Ras forms dimers on membrane surfaces via a protein-protein interface. Proc. Natl. Acad. Sci. 2014, 111, 2996. (*: equal contribution)
  6. Lohmüller, T.; Iversen, L.; Schmidt, M.; Rhodes, C.; Tu, H.-L.; Lin, W.-C.; Groves, J. Single molecule tracking on supported membranes with arrays of optical nanoantennas. Nano Lett. 2012, 12, 1717.
  7. Tu, H.-L.; Lin, Y.-S.; Lin, H.-Y.; Hung, Y.; Lo, L.-W.; Chen, Y.-F.; Mou, C.-Y. In-vitro studies of functionalized mesoporous silica nanoparticles for photodynamic therapy. Adv. Mater. 2009, 21, 172.
  8. Tu, H.-L.; Tsai, F.-Y.; Mou, C.-Y. One step synthesis of ordered mesostructural organic/silica nanocomposite with tunable fluorescence surfactants. J. Mater. Chem. 2008, 18, 1771.
  9. Tsai, F.-Y.; Tu, H.-L.; Mou, C.-Y. Nonionic fluorescent oligomeric surfactant for ordered mesoporous silica structure. J. Mater. Chem. 2006, 16, 348.

Update： 2017-07-28

Journal Paper
  1. Lin Jing, Jordi Christian, Son Minjun, Van Phan Hoang, Drayman Nir, Abasiyanik Mustafa Fatih, Vistain Luke, Tu Hsiung-Lin, Tay Savaş Ultra-sensitive digital quantification of proteins and mRNA in single cells. Nature Communications 2019, 10(1), 3544.
  2. Zhang Ce, Tu Hsiung-Lin, Jia Gengjie, Mukhtar Tanzila, Taylor Verdon, Rzhetsky Andrey, Tay Savaş Ultra-multiplexed analysis of single-cell dynamics reveals logic rules in differentiation. Science Advances 2019, 5(4), eaav7959.
  3. Sune M. Christensen, Meredith G. Triplet, Christopher Rhodes, Jeffrey S. Iwig, Hsiung-Lin Tu, Dimitrios Stamou, Jay T. Groves Monitoring The Waiting Time Sequence of Single Ras GTPase Activation Events Using Liposome Functionalized Zero Mode Waveguides. NANO LETTERS 2016, 16, 2890-2895.
  4. William Y. C. Huang, Qingrong Yan, Wan-Chen Lin, Jean K. Chung, Scott D. Hansen, Sune M. Christensen, Hsiung-Lin Tu, John Kuriyan, Jay T. Groves Phosphotyrosine-mediated LAT Assembly on Membranes Drives Kinetic Bifurcation in Recruitment Dynamics of The Ras Activator SOS. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2016, 113, 8218-8223.
  5. Sune M Christensen, Hsiung-Lin Tu, Jesse E Jun, Steven Alvarez, Meredith G Triplet, Jeffrey S Iwig, Kamlesh K Yadav, Dafna Bar-Sagi, Jeroen P Roose, Jay T Groves One-way Membrane Trafficking of SOS in Receptor-Triggered Ras Activation. NATURE STRUCTURAL & MOLECULAR BIOLOGY 2016, 23, 838-846.
  6. Wan-Chen Lin, Lars Iversen, Hsiung-Lin Tu, Christopher Rhodes, Sune M. Christensen, Jeffrey S. Iwig, Scott D. Hansen, William Y. C. Huang, Jay T. Groves H-Ras Forms Dimers on Membrane Surfaces via A Protein-Protein Interface. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2014, 111, 2996-3001.
  7. Lars Iversen, Hsiung-Lin Tu, Wan-Chen Lin, Sune M. Christensen, Steven M. Abel, Jeff Iwig, Hung-Jen Wu, Jodi Gureasko, Christopher Rhodes, Rebecca S. Petit, Scott D. Hansen, Peter Thill, Cheng-Han Yu, Dimitrios Stamou, Arup K. Chakraborty, John Kuriyan, Ras Activation by SOS: Allosteric Regulation by Altered Fluctuation Dynamics. SCIENCE 2014, 345, 50-54.
  8. T. Lohmüller, L. Iversen, M. Schmidt, C. Rhodes, Hsiung-Lin Tu, W.-C. Lin, J. T. Groves Single Molecule Tracking on Supported Membranes with Arrays of Optical Nanoantennas. NANO LETTERS 2012, 12, 1717-1721.
  9. Hsiung-Lin Tu, Yu-Shen Lin, Hsia-Yu Lin, Yann Hung, Leu-Wei Lo, Yang-Fang Chen, Chung-Yuan Mou In-vitro Studies of Functionalized Mesoporous Silica Nanoparticles for Photodynamic Therapy. ADVANCED MATERIALS 2009, 21, 172-177.
  10. Hsiung-Lin Tu, Fu-Yu Tsai, C.-Y. Mou One Step Synthesis of Ordered Mesostructural Organic/silica Nanocomposite with Tunable Fluorescence Surfactants. JOURNAL OF MATERIALS CHEMISTRY 2008, 18, 1771-1778.
  11. Fu-Yu Tsai, Hsiung-Lin Tu, Chung-Yuan Mou. Nonionic Fluorescent Oligomeric Surfactant for Ordered Mesoporous Silica Structure. JOURNAL OF MATERIALS CHEMISTRY 2006, 16, 348-350.
Book/Papers
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