Our research interests are primarily in the areas of organic synthesis and chemical biology. We are interested in using chemistry as tools to study and address in biology. The foremost focus centers on the developing novel chemical bioconjugations and related fluorescent smart probes for selective labeling of biomolecules in cells to understand cellular processes. In the field of organic synthesis, the Shie lab at IoC focuses on development new synthetic methodologies for the efficient and economical synthesis of biomedical significance glycoconjugates and carbohydrate-based small molecular inhibitors against infection diseases.
~ Antiviral and antibacterial drug discovery.
~ Fluorescence-forming probes and chemosensors upon chemical bioconjugation.
~ Development of novel chemical bioconjugation reactions in biological systems.
~ Fluorescent labeling chemistry of biomolecule in cell.