Institute of Chemistry, Academia Sinica--Yu-Ju Chen

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Proteomics and Mass Spectrometry

Yu-Ju Chen (陳玉如)

    886-2-55728660
    886-2-27831237
    yujuchen gate.sinica.edu.tw

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Distinguished Research Fellow(2019-)；President, Chemical Society located in Taipei (2023-2025)；Acting Director(2019~2021)；Director(2013~2019)；Deputy Director(2011-2013)； Research Fellow (2010-2019)；Associate Research Fellow (2005-2010)；Adjunt Professor, National Taiwan University (2007-)；Adjunt Professor, National Chia- Yi University (2007-)；Adjunct Research Fellow, Genomic Research Center (2004-Present)；Assistant Research Fellow (1999-2005)；Postdoctoral Fellow, National Tsing Hua University (1998-1999)；Postdoctoral Fellow, Ames Laboratory, U.S.A(1999)；Ph.D., Iowa State University (1997)；BS, National Taiwan University (1992)；President, Human Proteome Organization (HUPO) (2021-2022)； Vice President, Asia Oceana Human Proteome Organization (AOHUPO) (2017-2019)；President, Taiwan Proteomics Society (2008-2011)；Associate Editor, Analytical Chemistry, ACS (2020-present)；Editorial Board Member, European Journal of Mass Spectrometry (2012-2015)；

Cancer Proteomics:

Chen, Y.-J.; Roumeliotis, T.; Chang, Y.-H.; Chen, C.-T.; Han, C.-L.; Lin, M.-H.; Chen, H.-W.; Chang, G.-C.; Chang, Y.-L.; Wu, C.-T.; Lin, M.-W.; Hsieh, M.-S.; Wang, Y.-T.; Chen, Y.-R.; Jonassen, I.; Ghavidel, F. Z.; Lin, Z.-S.; Lin, K.-T.; Chen, C.-W.; Sheu, P.-Y.; Hung, C.-T. ; Huang, K.-C.; Yang, H.-C.; Lin, P.-Y.; Yen, T.-C.; Lin, Y.-W.; Wang, J.-H.; Raghav, L.; Lin, C.-Y.; Chen, Y.-S.; Wu, P.-S.; Lai, C.-T.; Weng, S.-H.; Su, K.-Y.; Chang, W.-H.; Tsai, P.-Y.; Robles, A. I.; Rodriguez, H.; Sung, T.-Y.; Chen, J.-S.; Yu, S.-L.; Choudhary , J. S.; Chen, H.-Y. ; Yang, P.-C.; Chen, Y.-J. Proteogenomic Landscape of Early Stage Non-smoking Lung Adenocarcinoma in East Asia. Cell, 2020, 182, 226-244. (Cover Story, highlighted by Nature Review Clinical Oncology (2020, 17, 519), Cancer Discovery)

Membrane Proteomics:

Weldemariam, M. M.; Han, C.-L.; Shekari, F.; Kitata, R. B.; Chuang, C.-Y.; Hsu, W.-T.; Kuo, H.-C.; Choong, W.-K.; Sung, T.-Y.; He, F.-C.; Chung, M. C. M.; Salekdeh, G. H.; Chen, Y.-J. Subcellular Proteome Landscape of Human Embryonic Stem Cells Revealed Missing Membrane Proteins. J Proteome Res. 2018, 17, 4138-4151.
Dimayacyac-Esleta, B. R. ; Tsai, C.-F.; Kitata, R. B.; Lin, P.-Y.; Choong, W. K.; Lin, T.-D.; Wang, Y.-T.; Weng, S.-H.; Yang, P.-C.; Arco, S.; Sung, T.-Y.; Chen, Y.-J. Rapid High-pH Reverse Phase StageTip for Sensitive Small-Scale Membrane Proteomic Profiling. Anal Chem, 2015, 87, 12016–12023.
Han, C.-L.; Chen, J.-S.; Chan, E.-C.; Wu, C.-P.; Yu, K.-H.; Chen, K.-T.; Tsou, C.-C.; Tsai, C.-F.; Chien, C.-W.; Kuo, Y.-B.; Lin, P.-Y.; Yu, J.-S.; Hsueh, C.; Chen, M.-C.; Chan, C.-C.; Chang, Y.-S.; Chen, Y.-J. An Informatics-assisted Label-free Approach for Personalized Tissue Membrane Proteomics: Case Study on Colorectal Cancer. Mol. Cell. Proteomics, 2011, 10, 1-15.
Han, C.-L.; Chien, C.-W.; Chen, W.-C.; Chen, Y.-R.; Wu, C.-P.; Li, H.; Chen, Y.-J. A Multiplexed Quantitative Strategy for Membrane Proteomics: Opportunities for Mining Therapeutic Targets for Autosomal-Dominant Polycystic Kidney Disease.Mol. Cell. Proteomics, 2008, 7, 1983–1997.
Huang, T.-K.; Han, C.-L.; Lin, S.-I; Chen, Y.-J.; Tsai, Y.-C.; Chen, Y.-R.; Chen, J.-W.; Lin, W.-Y.; Chen, P.-M.; Liu, T.-Y.; Chen, Y.-S.; Sun, C.-M. ; Chiou, T.-J. Identification of Downstream Components of Ubiquitin-Conjugating Enzyme PHOSPHATE2 by Quantitative Membrane Proteomics in Arabidopsis Roots. The Plant Cell, 2013, 25, 4044-4060.

Phosphoproteomics:

Kitata, R. B.; Choong, W.-K.; Tsai, C.-F.; Lin, P.-Y.; Chen, B.-S.; Chang, Y.-C.; Nesvizhskii, A. I.; Sung, T.-Y.; Chen, Y.-J.
A Data-independent Acquisition-based Global Phosphoproteomics System Enables Deep Profiling. Nat. Commun. 2021, 12, 2539.
Tsai, C.-F.; Wang, Y.-T.; Yen, H.-Y.; Tsou, C.-C.; Ku, W.-C.; Lin, P.-Y.; Chen, H.-Y.; Nesvizhskii, A.; Ishihama, Y.; Chen, Y.-J. Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics. Nat. Commun, 2015, doi:10.1038/ncomms7622.
Wu, J.-L.; Wu, H.-Y.; Tsai, D.-Y.; Chiang, M.-F.; Chen, Y.-J.; Gao, S.; Lin, C.-C.; Lin, C.-H.; Khoo, K.-H.; Chen, Y.-J.; Lin, K.-I
Temporal Regulation of Lsp1 O-GlcNAcylation and Phosphorylation During Apoptosis of Activated B Cells. Nat. Commun., 2016, 7:12526.
Amit, E.; Obena, R. P.; Wang, Y.-T.; Zhuravel, R.; Reyes, A.; Elbaz, S.; Rotem, D.; Porath, D.; Friedler, A.; Chen, Y.-J.; Yitzchaik, S. Integrating Proteomics with Electrochemistry for Identifying Kinase Biomarkers. Chem. Sci., 2015, 6, 4756-4766.
Tsai, C.-F.; Hsu, C.-C.; Hung, J.-N.; Wang, Y.-T.; Choong, W.-K.; Zeng, M.-Y.; Lin, P.-Y.; Hong, R.-W.; Sung, T.-Y.; Chen, Y.-J. Sequential Phosphoproteomic Enrichment through Complementary Metal-directed Immobilized Metal Ion Affinity Chromatography. Anal. Chem. 2013, 86, 685–693.
Tsai, C.-F.; Wang, Y.-T.; Chen, Y.-R.; Lai, C.-Y.; Lin, P.-Y.; Pan, K.-T.; Chen, J.-Y.; Khoo, K.-H.; Chen, Y.-J. Immobilized Metal Affinity Chromatography Revisited: pH/Acid Controltoward High Selectivity in Phosphoproteomics. J. Proteome Res. 2008, 7, 4058-4069.

Nanoprobe-based Mass Spectrometry for Targeted Proteomics and Glycoproteomics:

Gizaw, E.; Tolesa, M. L. D.; Lee, M.-J.; Tseng, M.-C.; Chen, Y.-J. Direct Oligosaccharide Profiling using Thin-Layer Chromatography Coupled with Ionic Liquid-Stabilized Nanomatrix-Assisted Laser Desorption Ionization Mass Spectrometry. Anal. Chem. 2019, 91, 11544–11552.
Rosa, M. A.; Chen, W.-C.; Chen, Y.-J.; Obena, R.; Chang, C.-H.; Capangpangan, R.; Su, T.-H.; Chen, C.-L.; Chen, P.-J.; Chen, Y.-J. One-Pot Two-Nanoprobe Assay Uncovers Targeted Glycoprotein Biosignature. Anal. Chem. 2017, 89, 3973–3980.
Wu, D.-C.; Wang, K.-Y.; Wang, S. S.W.; Huang, C.-M.; Lee, Y.-W.; Chen, M. I.; Chuang, S.-A.; Chen, S.-H.; Lu, Y.-W.; Lin, C.-C.; Lee, K.-W.; Hsu, W.-H.; Wu, K.-P.; Chen, Y.-J. Exploring the expression bar code of SAA variants for gastric cancer detection. Proteomics 2017, 17, doi: 10.1002/pmic.201600356 (Cover Story).
Lu, Y.-W.; Chien, C.-W.; Lin, P.-C.; Huang, L.-D.; Chen, C.-Y.; Wu, S.-W.; Han, C.-L.; Khoo, K.-H.; Lin, C.-C.; Chen, Y.-J. BAD-Lectins: Boronic Acid-Decorated Lectins with Enhanced Binding Affinity for theSelective Enrichment of Glycoproteins. Anal. Chem. 2013, 85, 8268–8276.
Lin, P.-C.; Chou, P.-H.; Chen, S.-H.; Liao, H. K.; Wang, K.-Y.; Chen, Y.-J.; Lin, C.-C. Ethylene Glycol-Protected Magnetic Nanoparticles for Multiplexed Immunoassay in Human Plasma. Small 2006, 2, 485-489. (Cover Story)
Lin, P.-C.; Tseng, M.-C.; Su, A.-K.; Lin, C.-C.; Chen, Y.-J. Functionalized Magnetic Nanoparticles for Small Molecule Isolation, Identification and Quantification. Anal. Chem. 2007, 79, 3401-3408.

Update： 2023-11-07

Muneer Gul, Chen Ciao‐Syuan, Chen Yu‐Ju* Advancements in Global Phosphoproteomics Profiling: Overcoming Challenges in Sensitivity and Quantification. PROTEOMICS 2024-12-18, 25, e202400087.
Muneer Gul, Gebreyesus Sofani Tafesse, Chen Ciao‐Syuan, Lee Tzu‐Tsung, Yu Fengchao, Lin Chih‐An, Hsieh Min‐Shu, Nesvizhskii Alexey I., Ho Chao‐Chi, Yu Sung‐Liang, Tu Hsiung‐Lin*, Chen Yu‐Ju* Mapping Nanoscale‐To‐Single‐Cell Phosphoproteomic Landscape by Chip‐DIA. Advanced Science 2024-10-14, 2402421, 2402421-2402421.
Muneer Gul, Chen Ciao-Syuan, Lee Tzu-Tsung, Chen Bo-Yu, Chen Yu-Ju* A Rapid One-Pot Workflow for Sensitive Microscale Phosphoproteomics. Journal of Proteome Research 2024-07-22, 23(8), 3294-3309.
Pradita Tiara, Chen Yi-Ju, Su Tung-Hung, Chang Kun-Hao, Chen Pei-Jer, Chen Yu-Ju* Data Independent Acquisition Mass Spectrometry Enhanced Personalized Glycosylation Profiling of Haptoglobin in Hepatocellular Carcinoma. Journal of Proteome Research 2024-07-12, 23(8), 3571-3584.
Yang Jhih-Ci, Chen Shih-Pin*, Wang Yen-Feng, Chang Chan-Hua, Chang Kun-Hao, Fuh Jong-Ling, Chow Lok-Hi, Han Chia-Li*, Chen Yu-Ju*, Wang Shuu-Jiun* Cerebrospinal Fluid Proteome Map Reveals Molecular Signatures of Reversible Cerebral Vasoconstriction Syndrome. MOLECULAR & CELLULAR PROTEOMICS 2024-07, 23(7), 100794.
Yang Jhih-Ci, Hsu Tzi-Hui, Chen Ciao-Syuan, Yu Jou-Hui, Lin Kuo-I*, Chen Yu-Ju* Enhanced Proteomic Coverage in Tissue Microenvironment by Immune Cell Subtype Library-Assisted DIA-MS. MOLECULAR & CELLULAR PROTEOMICS 2024-07, 23(7), 100792.
Chang Chiao‐Chun, Tai Irene‐Ya, Chan Shen‐Shian, Lin Yu‐Hsuan, Chen Yu‐Ju, Chen Yi‐Ju* Developing tyrosine phosphoproteome libraries and dual quantification using a hybrid DIA approach. Journal of the Chinese Chemical Society 2024-06-19, 71(8), 897-907.
Lu Yueh-Feng, Chang Ya-Hsuan, Chen Yi-Ju, Hsieh Min-Shu, Lin Mong-Wei, Hsu Hsao-Hsun, Han Chia-Li, Chen Yu-Ju, Yu Sung-Liang, Chen Jin-Shing*, Chen Hsuan-Yu* Proteomic profiling of tumor microenvironment and prognosis risk prediction in stage I lung adenocarcinoma. Lung Cancer 2024-05, 191, 107791.
Han Chia-Li, Lai Chi-Ting, Reyes Aaron James, Yang Hao-Chin, Lu Jin-Ying, Shih Shyang-Rong, Chen Kuen-Yuan, Hoofnagle Andrew N., Yu Sung-Liang, Bocik William, Hiltke Tara, Chiu Huan-Chi, Wan Ching-Yi, Rodriguez Henry, Zhang Victoria*, Chen Yu-Ju* Lessons learned: establishing a CLIA-equivalent laboratory for targeted mass spectrometry assays – navigating the transition from research to clinical practice. Clinical Proteomics 2024-02-22, 21(1), 1-11.
Tomioka Ryota, Tomioka Ayana, Ogata Kosuke, Chan Hsin-Ju, Chen Li-Yu, Guzman Ulises H., Xuan Yue, Olsen Jesper V., Chen Yu-Ju, Ishihama Yasushi* Extending the Coverage of Lys-C/Trypsin-Based Bottom-up Proteomics by Cysteine S-Aminoethylation. Journal of the American Society for Mass Spectrometry 2024-01-29, 35(2), 386-396.
Li Hao-Kang, Wu Tai-Sheng, Kuo Yi-Chiu, Hsiao Ching-Wen, Yang Hsiu-Ping, Lee Chia-Yun, Leng Pei-Ju, Chiang Yun-Jung, Cheng Zih-Fei, Yang Sen-Han, Lin Yan-Liang, Chen Li-Yu, Chen Ciao-Syuan, Chen Yu-Ju, Hsiao Shih-Chia, Tang Sai-Wen A Novel Allogeneic Rituximab-Conjugated Gamma Delta T Cell Therapy for the Treatment of Relapsed/Refractory B-Cell Lymphoma. Cancers 2023-10-04, 15(19), 4844.
Wu Pei-Shan, Lin Miao-Hsia, Hsiao Jye-Chian, Lin Pei-Yi, Pan Szu-Hua, Chen Yu-Ju EGFR-T790M Mutation–Derived Interactome Rerouted EGFR Translocation Contributing to Gefitinib Resistance in Non-Small Cell Lung Cancer. Molecular Cellular Proteomics 2023-09, 22(9), 100624.
Gebreyesus Sofani Tafesse, Muneer Gul, Huang Chih-Cheng, Siyal Asad Ali, Anand Mihir, Chen Yu-Ju, Tu Hsiung-Lin Recent advances in microfluidics for single-cell functional proteomics. Lab on a Chip 2023-02-22, 23(7), 1726-1751.
Shih Yu-Tsung, Wei Shu-Yi, Chen Jin-Hua, Wang Wei-Li, Wu Hsin-Yi, Wang Mei-Cun, Lin Chia-Yu, Lee Pei-Lin, Lin Chih-Yuan, Chiang Hung-Che, Chen Yu-Ju, Chien Shu, Chiu Jeng-Jiann Vinculin phosphorylation impairs vascular endothelial junctions promoting atherosclerosis. European Heart Journal 2022-11-16, 44(4), 304-318.
Shen Chi-Ya, Chang Wen-Hsin, Chen Yi-Ju, Weng Chia-Wei, Regmi Prabha, Kier Mickiela K. K., Su Kang-Yi, Chang Gee-Chen, Chen Jin-Shing, Chen Yu-Ju, Yu Sung-Liang Tissue Proteogenomic Landscape Reveals the Role of Uncharacterized SEL1L3 in Progression and Immunotherapy Response in Lung Adenocarcinoma. Journal of Proteome Research 2022-11-09, 22(4), 1056-1070.
Omenn Gilbert S., Lane Lydie, Overall Christopher M., Pineau Charles, Packer Nicolle H., Cristea Ileana M., Lindskog Cecilia, Weintraub Susan T., Orchard Sandra, Roehrl Michael H. A., Nice Edouard, Liu Siqi, Bandeira Nuno, Chen Yu-Ju, Guo Tiannan, Aebersold Ruedi, Moritz Robert L., Deutsch Eric W. The 2022 Report on the Human Proteome from the HUPO Human Proteome Project. Journal of Proteome Research 2022-11-01, 22(4), 1024-1042.
Shih Yu-Yin, Lin Hsien-Ya, Jan Hau-Ming, Chen Yu-Ju, Ong Lih-Lih, Yu Alice Lin-Tsing, Lin Chun-Hung S-glutathionylation of Hsp90 enhances its degradation and correlates with favorable prognosis of breast cancer. Redox Biology 2022-11, 57, 102501.
Chan Hsin‐Ju, Chen Li‐Yu, Chiu Huan‐Chi, Chen Yu‐Ju Membrane proteomic profiling enhances drug target detection. Journal of the Chinese Chemical Society 2022-08, 69(8), 1338-1345.
Chang Wen‐Hsin, Chen Yi‐Ju, Hsiao Yi‐Jing, Chiang Ching‐Cheng, Wang Chia‐Yu, Chang Ya‐Ling, Hong Qi‐Sheng, Lin Chien‐Yu, Lin Shr‐Uen, Chang Gee‐Chen, Chen Hsuan‐Yu, Chen Yu‐Ju, Chen Ching‐Hsien, Yang Pan‐Chyr, Yu Sung‐Liang Reduced symmetric dimethylation stabilizes vimentin and promotes metastasis in MTAP-deficient lung cancer. EMBO reports 2022-06-29, 23(8), 1-20.
Li Pei‐Jhen, Kawade Sachin Kisan, Adak Avijit K., Shen Yu‐Ju, Fan Chen‐Yo, Hsieh Yu‐Heng, Angata Takashi, Chen Yu‐Ju, Lin Chun‐Cheng <scp>Ligand‐assisted imprinting‐probe‐labeling</scp> strategy reveals Siglec‐7 ‐ glycoprotein interactions. Journal of the Chinese Chemical Society 2022-06-07, 69(8), 1326-1337.
Kitata Reta Birhanu, Yang Jhih‐Ci, Chen Yu‐Ju Advances in data‐independent acquisition mass spectrometry towards comprehensive digital proteome landscape. Mass Spectrometry Reviews 2022-05-29, e21781, 1-25.
Wu Jung-Lin, Wu Hsin-Yi, Wu Shang-Ju, Tsai Ho-Yang, Weng Shao-Hsing, Lin Kuen-Tyng, Lin Liang-In, Yao Chi-Yuan, Zamanova Margarita, Lee Yi-Yuan, Angata Takashi, Tien Hwei-Fang, Chen Yu-Ju, Lin Kuo-I Phosphoproteomics Reveals the Role of Constitutive KAP1 Phosphorylation by B-cell Receptor Signaling in Chronic Lymphocytic Leukemia. Molecular Cancer Research 2022-05-09, 20(8), 1222-1232.
Gebreyesus Sofani Tafesse, Siyal Asad Ali, Kitata Reta Birhanu, Chen Eric Sheng-Wen, Enkhbayar Bayarmaa, Angata Takashi, Lin Kuo-I, Chen Yu-Ju, Tu Hsiung-Lin Streamlined single-cell proteomics by an integrated microfluidic chip and data-independent acquisition mass spectrometry. Nature Communications 2022-01-10, 13(1), 37.
Siyal Asad Ali, Chen Eric Sheng-Wen, Chan Hsin-Ju, Kitata Reta Birhanu, Yang Jhih-Ci, Tu Hsiung-Lin, Chen Yu-Ju* Sample Size-Comparable Spectral Library Enhances Data-Independent Acquisition-Based Proteome Coverage of Low-Input Cells. Analytical Chemistry 2021-12-14, 10, 1021.
Yi-Ju Chen, Ta-Chi Yen, Yu-Hsien Lin, Yan-Lin Chen, Kay-Hooi Khoo , Yu-Ju Chen* ZIC-cHILIC-Based StageTip for Simultaneous Glycopeptide Enrichment and Fractionation toward Large-Scale N-Sialoglycoproteomics. Analytical Chemistry 2021-12-07, 93(48), 15931-15940.
Tiara Pradita, Yi-Ju Chen, Elias Gizaw Mernie, Sharine Noelle Bendulo, Yu-Ju Chen* ZIC-cHILIC Functionalized Magnetic Nanoparticle for Rapid and Sensitive Glycopeptide Enrichment from <1 µL Serum. Nanomaterials 2021-08-24, 11(9), 2159.
Mernie Elias Gizaw, Tseng Mei‐Chun, Wu Wen‐Ti, Liu Tzu‐Ming, Chen Yu‐Ju* Nanoprobe‐based mass spectrometry and Fourier transform infrared spectroscopy for rapid phospholipid profiling. Journal of the Chinese Chemical Society 2021-08-23, SPECIAL ISSUE, 284.
Kitata Reta Birhanu, Choong Wai-Kok, Tsai Chia-Feng, Lin Pei-Yi, Chen Bo-Shiun, Chang Yun-Chien, Nesvizhskii Alexey I., Sung Ting-Yi, Chen Yu-Ju A data-independent acquisition-based global phosphoproteomics system enables deep profiling. Nature Communications 2021-05-05, 12(1), 2539.
Reyes Aaron James F., Kitata Reta Birhanu, dela Rosa Mira Anne C., Wang Yi-Ting, Lin Pei-Yi, Yang Pan-Chyr, Friedler Assaf, Yitzchaik Shlomo, Chen Yu-Ju Integrating site-specific peptide reporters and targeted mass spectrometry enables rapid substrate-specific kinase assay at the nanogram cell level. Analytica Chimica Acta 2021-04-22, 1155, 338341.
Hewage Ranuka T., Huang Rou-Jie, Lai Shu-Jung, Lien Ya-Chu, Weng Shao-Hsing, Li Dehai, Chen Yu-Ju, Wu Shih-Hsiung, Chein Rong-Jie, Lin Hsiao-Ching An Enzyme-Mediated Aza-Michael Addition Is Involved in the Biosynthesis of an Imidazoyl Hybrid Product of Conidiogenone B. Organic Letters 2021-02-11, 23(5), 1904-1909.
Xuan Yue, Bateman Nicholas W., Gallien Sebastien, Goetze Sandra, Zhou Yue, Navarro Pedro, Hu Mo, Parikh Niyati, Hood Brian L., Conrads Kelly A., Loosse Christina, Kitata Reta Birhanu, Piersma Sander R., Chiasserini Davide, Zhu Hongwen, Hou Guixue, Tahir Muhammad, Macklin Andrew, Khoo Amanda, Sun Xiuxuan, Crossett Ben, Sickmann Albert, Chen Yu-Ju, Jimenez Connie R., Zhou Hu, Liu Siqi, Larsen Martin R., Kislinger Thomas, Chen Zhinan, Parker Benjamin L., Cordwell Stuart J., Wollscheid Bernd, Conrads Thomas P. Standardization and harmonization of distributed multi-center proteotype analysis supporting precision medicine studies. Nature Communications 2020-10-16, 11(1), 5248.
Chen Yi-Ju, Roumeliotis Theodoros I., Chang Ya-Hsuan, Chen Ching-Tai, Han Chia-Li, Lin Miao-Hsia, Chen Huei-Wen, Chang Gee-Chen, Chang Yih-Leong, Wu Chen-Tu, Lin Mong-Wei, Hsieh Min-Shu, Wang Yu-Tai, Chen Yet-Ran, Jonassen Inge, Ghavidel Fatemeh Zamanzad, Lin Ze-Shiang, Lin Kuen-Tyng, Chen Ching-Wen, Sheu Pei-Yuan, Hung Chen-Ting, Huang Ke-Chieh, Yang Hao-Chin, Lin Pei-Yi, Yen Ta-Chi, Lin Yi-Wei, Wang Jen-Hung, Raghav Lovely, Lin Chien-Yu, Chen Yan-Si, Wu Pei-Shan, Lai Chi-Ting, Weng Shao-Hsing, Su Kang-Yi, Chang Wei-Hung, Tsai Pang-Yan, Robles Ana I., Rodriguez Henry, Hsiao Yi-Jing, Chang Wen-Hsin, Sung Ting-Yi, Chen Jin-Shing, Yu Sung-Liang, Choudhary Jyoti S., Chen Hsuan-Yu, Yang Pan-Chyr, Chen Yu-Ju* Proteogenomics of Non-smoking Lung Cancer in East Asia Delineates Molecular Signatures of Pathogenesis and Progression. Cell 2020-07-09, 182(1), 226-244.e17.
Chen Li-Ying, Lin Kuo-Ray, Chen Yi-Ju, Chiang Yun-Jung, Ho Kun-Chin, Shen Li-Fen, Song I-Wen, Liu Kai-Ming, Yang-Yen Hsin-Fang, Chen Yu-Ju, Chen Yuan-Tsong, Liu Fu-Tong, Yen Jeffrey J.Y.* Palmitoyl Acyltransferase Activity of ZDHHC13 Regulates Skin Barrier Development Partly by Controlling PADi3 and TGM1 Protein Stability. Journal of Investigative Dermatology 2020-05, 140(5), 959-970.e3.
Chang Lo‐Yu, Fan Sabrina Mai‐Yi, Liao Yen‐Chen, Wang Wei‐Hung, Chen Yu‐Ju, Lin Sung‐Jan* Proteomic Analysis Reveals Anti‐Fibrotic Effects of Blue Light Photobiomodulation on Fibroblasts. Lasers in Surgery and Medicine 2020-04, 52, 358-372.
Chan Yu‐Tzu, Lai Alan C.‐Y., Lin Ruey‐Jen, Wang Ya‐Hui, Wang Yi‐Ting, Chang Wen‐Wei, Wu Hsin‐Yi, Lin Yu‐Ju, Chang Wen‐Ying, Wu Jen‐Chine, Yu Jyh‐Cherng, Chen Yu‐Ju*, Yu Alice L.* GPER‐induced signaling is essential for the survival of breast cancer stem cells. International Journal of Cancer 2020-03-15, 146, 1674-1685.
Chien Chih‐Wei, Lo Yu‐Shu, Wu Hsin‐Yi, Hsuan Yogi, Lin Chi‐Kang, Chen Yu‐Ju, Lin Willie*, Han Chia‐Li* Transcriptomic and Proteomic Profiling of Human Mesenchymal Stem Cell Derived from Umbilical Cord in the Study of Preterm Birth. PROTEOMICS – Clinical Applications 2020-01, 14(1), 1900024.
Itang Corazon Ericka Mae M., Gaza Jokent T., Masacupan Dan Jethro M., Batoctoy Dessa Camille R., Chen Yu-Ju, Nellas Ricky B., Yu Eizadora T. Identification of Conomarphin Variants in the Conus eburneus Venom and the Effect of Sequence and PTM Variations on Conomarphin Conformations. Marine Drugs 2020, 18(10) 503.
Mernie Elias Gizaw, Tolesa Leta Deressa, Lee Ming-Jer, Tseng Mei-Chun, Chen Yu-Ju Direct Oligosaccharide Profiling Using Thin-Layer Chromatography Coupled with Ionic Liquid-Stabilized Nanomatrix-Assisted Laser Desorption-Ionization Mass Spectrometry. Analytical Chemistry 2019, 91(18) 11544-11552.
Fan Chen-Yo, Hou Yi-Ren, Adak Avijit K., Waniwan Juanilita T., dela Rosa Mira Anne C., Low Penk Yeir, Angata Takashi, Hwang Kuo-Chu, Chen Yu-Ju, Lin Chun-Cheng Boronate affinity-based photoactivatable magnetic nanoparticles for the oriented and irreversible conjugation of Fc-fused lectins and antibodies. Chemical Science 2019, 10(37) 8600-8609.
Hu Chun-Mei, Tien Sui-Chih, Hsieh Ping-Kun, Jeng Yung-Ming, Chang Ming-Chu, Chang Yu-Ting, Chen Yi-Ju, Chen Yu-Ju, Lee Eva Y.-H.P., Lee Wen-Hwa High Glucose Triggers Nucleotide Imbalance through O-GlcNAcylation of Key Enzymes and Induces KRAS Mutation in Pancreatic Cells. Cell Metabolism 2019, 29(6) 1334-1349.e10.
Fan Sabrina Mai-Yi, Tsai Chia-Feng, Yen Chien-Mei, Lin Miao-Hsia, Wang Wei-Hung, Chan Chih-Chieh, Chen Chih-Lung, Phua Kyle K.L., Pan Szu-Hua, Plikus Maksim V., Yu Sung-Liang, Chen Yu-Ju, Lin Sung-Jan Inducing hair follicle neogenesis with secreted proteins enriched in embryonic skin. Biomaterials 2018, 167, 121-131.
Paik Young-Ki, Lane Lydie, Kawamura Takeshi, Chen Yu-Ju, Cho Je-Yoel, LaBaer Joshua, Yoo Jong Shin, Domont Gilberto, Corrales Fernando, Omenn Gilbert S., Archakov Alexander, Encarnación-Guevara Sergio, Lui Siqi, Salekdeh Ghasem Hosseini, Cho Jin-Young, Kim Chae-Yeon, Overall Christopher M. Launching the C-HPP neXt-CP50 Pilot Project for Functional Characterization of Identified Proteins with No Known Function. Journal of Proteome Research 2018, 17(12), 4042-4050.
Chatterjee Biswanath, Lin Miao-Hsia, Chen Chun-Chang, Peng Kai-Lin, Wu Mu-Sheng, Tseng Mei-Chun, Chen Yu-Ju, Shen Che-Kun James DNA Demethylation by DNMT3A and DNMT3B in vitro and of Methylated Episomal DNA in Transiently Transfected Cells. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 2018, 1861(11), 1048-1061.
Shekari Faezeh, Han Chia-Li, Lee Jaesuk, Mirzaei Mehdi, Gupta Vivek, Haynes Paul A., Lee Bonghee, Baharvand Hossein, Chen Yu-Ju, Hosseini Salekdeh Ghasem Surface markers of human embryonic stem cells: a meta analysis of membrane proteomics reports. Expert Review of Proteomics 2018, 15(11), 911-922.
Mamie Lih Tung-Shing, Choong Wai-Kok, Chen Yu-Ju, Sung Ting-Yi Evaluating the Possibility of Detecting Variants in Shotgun Proteomics via LeTE-Fusion Analysis Pipeline. Journal of Proteome Research 2018, 17(9), 2937-2952.
Weldemariam Mehari Muuz, Han Chia-Li, Shekari Faezeh, Kitata Reta Birhanu, Chuang Ching-Yu, Hsu Wei-Ting, Kuo Hung-Chih, Choong Wai-Kok, Sung Ting-Yi, He Fu-Chu, Chung Maxey Ching Ming, Salekdeh Ghasem Hosseini, Chen Yu-Ju Subcellular Proteome Landscape of Human Embryonic Stem Cells Revealed Missing Membrane Proteins. Journal of Proteome Research 2018, 17(12), 4138-4151.
Chen Wei-Ta, Hsu Wei-Tse, Yen Meng-Hua, Changou Chun A., Han Chia-Li, Chen Yu-Ju, Cheng Ji-Yen, Chang Tzu-Hao, Lee Oscar Kuang-Sheng, Ho Jennifer Hui-Chun Alteration of mesenchymal stem cells polarity by laminar shear stimulation promoting β-catenin nuclear localization. Biomaterials 2018, 190-191, 1-10.
Waniwan Juanilita T., Chen Yi-Ju, Capangpangan Rey, Weng Shao-Hsing, Chen Yu-Ju Glycoproteomic Alterations in Drug-Resistant Nonsmall Cell Lung Cancer Cells Revealed by Lectin Magnetic Nanoprobe-Based Mass Spectrometry. Journal of Proteome Research 2018, 17(11), 3761-3773.
Hui-Yin Chang, Ching-Tai Chen, Chu-Ling Ko, Yi-Ju Chen, Yu-Ju Chen, Wen-Lian Hsu, Chiun-Gung Juo*, Ting-Yi Sung* iTop-Q: an Intelligent Tool for Top-down Proteomics Quantitation Using DYAMOND Algorithm. Analytical Chemistry 2017-11-22, 89(24), 13128-13136.
Wei-Sheng Tien, Pei-Mien Chen, Ching-Yu Chuang, Shook-Mun Lui, Hung-Chih Kuo, Yu-Ju Chen, Kun-Pin Wu* Combining membrane proteomics and computational three-way pathway analysis revealed signalling pathways preferentially regulated in human iPSCs and human ESCs. Scientific Reports 2017-11-08, 7(1), 15055-1-15055-14.
Wai-Kok Choong, Tung-Shing Mamie Lih, Yu-Ju Chen, Ting-Yi Sung* Decoding the Effect of Isobaric Substitutions on Identifying Missing Proteins and Variant Peptides in Human Proteome. Journal of Proteome Research 2017-09-20, 16(12), 4415-4424.
Lanyi Chang, Yi-Ju Chen, Chan-Yo Fan, Chin-Ju Tang, Yi-Hsiu Chen, Penk-Yeir Low, Albert Ventura, Chun-Cheng Lin, Yu-Ju Chen, Takashi Angata* Identification of Siglec Ligands Using a Proximity Labeling Method. Journal of Proteome Research 2017-09-13, 16(10), 3929-3941.
Faezeh Shekari, Hossein Nezari, Yu-Ju Chen*, Hossein Baharvand*, Ghasem Hosseini Salekdeh* Data for Whole and Mitochondrial Proteome of Human Embryonic Stem Cells. Data in Brief 2017-06-12, 13, 371-376.
Deng-Chyang Wu*, Kai-Yi Wang*, Sophie S.W. Wang, Ching-Min Huang, Yi-Wei Lee, Michael Isaac Chen, Szu-An Chuang, Shu-Hua Chen, Ying-Wei Lu, Chun-Cheng Lin, Ka-Wo Lee, Wen-Hung Hsu, Wu Kun-Pin*, Yu-Ju Chen Exploring the expression bar code of SAA variants for gastric cancer detection. PROTEOMICS 2017-06, 17(11), 1600356.
Li-Fen Shen, Yi-Ju Chen, Kai-Ming Liu, Amir N. Saleem Haddad, I-Wen Song, Hsiao-Yuh Roan, Li-Ying Chen, Jeffrey J. Y. Yen, Yu-Ju Chen, Jer-Yuarn Wu, Yuan-Tsong Chen* Role of S-Palmitoylation by ZDHHC13 in Mitochondrial function and Metabolism in Liver. Scientific Reports 2017-05-19, 7(1), 2128-1-2128-14.
Faezeh Shekari, Hossein Nezari, Mehran Rezaei Larijani, Chia-Li Han, Hossein Baharvand*, Yu-Ju Chen*, Ghasem Hosseini Salekdeh* Proteome analysis of human embryonic stem cells organelles. Journal of Proteomics 2017-04-20, 162, 108-118.
Mira Anne dela Rosa, Wei-Chun Chen, Yi-Ju Chen, Rofeamor Obena, Chih-Hsiang Chang, Rey Capangpangan, Tung-Hung Su, Chi-Ling Chen, Pei-Jer Chen, Yu-Ju Chen* One-Pot Two-Nanoprobe Assay Uncovers Targeted Glycoprotein Biosignature. ANALYTICAL CHEMISTRY 2017-03-21, 89 (7), 3973-3980.
Meng-Tsz Tsai, Yu-Jen Chen, Ching-Yi Chen, Mong-Hsun Tsai, Chia-Li Han, Yu-Ju Chen, Harry J Mersmann, Shih-Torng Ding* Identification of Potential Plasma Biomarkers for Nonalcoholic Fatty Liver Disease by Integrating Transcriptomics and Proteomics in Laying Hens. The Journal of Nutrition 2017-03, 147(3), 293-303.
Yi-Ting Wang, Szu-Hua Pan, Chia-Feng Tsai, Ting-Chun Kuo, Hsin-Yung Yen, Wai-Kok Choong, Hsin-Yi Wu, Yuan-Ling Hsu, Tse-Ming Hong, Ting-Yi Sung, Pan-Chyr Yang, Yu-Ju Chen* Phosphoproteomics Reveals HMGA1, a CK2 Substrate, as a Drug-Resistant Target in Non-Small Cell Lung Cancer. SCIENTIFIC REPORTS 2017-01-25, ,.
Nai-Wen Chang*, Hong-Jie Dai*, Yung-Yu Shih, Chi-Yang Wu, Mira Anne C. Dela Rosa, Rofeamor P. Obena, Yu-Ju Chen, Wen-Lian Hsu*, Yen-Jen Oyang* Biomarker identification of hepatocellular carcinoma using a methodical literature mining strategy. DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION 2017-01-04, (2017), 1-13.
Han-Tsang Wu*, Yi-Chih Kuo*, Jung-Jyh Hung, Chi-Hung Huang, Wei-Yi Chen, Teh-Ying Chou, Yeh Chen, Yi-Ju Chen, Yu-Ju Chen, Wei-Chung Cheng, Shu-Chun Teng, Kou-Juey Wu* K63-Polyubiquitinated HAUSP Deubiquitinates HIF-1α and Dictates H3K56 Acetylation Promoting Hypoxia-Induced Tumour Progression. NATURE COMMUNICATIONS 2016-12-09, 7(13644 ), doi:10.1038/ncomms13644.
Yi-Hsuan Chen, Hua-Yi Hsu, Ming-Tyng Yeh, Chen-Cheng Chen, Chang-Yu Huang, Ying-Hsuan Chung, Zee-Fen Chang, Wei-Chen Kuo, Nei-Li Chan, Jui-Hsia Weng, Bon-chu Chung, Yu-Ju Chen, Cheng-Bang Jian, Ching-Chieh Shen, Hwan-Ching Tai, Sheh-Yi Sheu*, Jim-Min Fa Chemical Inhibition of Human Thymidylate Kinase and Structural Insights into the Phosphate Binding Loop and Ligand-Induced Degradation. JOURNAL OF MEDICINAL CHEMISTRY 2016-10-17, 59 (21), 9906-9918.
Chih-Wei Chen, Ning Tsao, Lin-Yi Huang, Yun Yen, Xiyong Liu, Christine Lehman, Yuh-Hwa Wang, Mei-Chun Tseng, Yu-Ju Chen, Yi-Chi Ho, Chian-Feng Chen, Zee-Fen Chang* Download: The Impact of Dupase on Ribonucleotide Reductase-Induced Genome Instability in Cancer Cells.. CELL REPORTS 2016-08-02, 16(5), 1287-1299.
Chih-Chiang Tsou,Chia-Feng Tsai,Guoci Teo, Yu-Ju Chen, Alexey I. Nesvizhskii* Untargeted, Spectral Library-Free Analysis of Data Independent Acquisition Proteomics Data Generated Using Orbitrap Mass Spectrometers. PROTEOMICS 2016-08, 16, (15-16).
Jung-Lin Wu, Hsin-Yi Wu, Dong-Yan Tsai, Ming-Feng Chiang, Yi-Ju Chen, Shijay Gao, Chun-Cheng Lin, Chun-Hung Lin, Kay-Hooi Khoo, Yu-Ju Chen*, Kuo-I Lin* Temporal Regulation of Lsp1 O-GlcNAcylation and Phosphorylation During Apoptosis of Activated B cells. NATURE COMMUNICATIONS 2016-08, 7:12526, doi: 10.1038/ncomms12526.
Indah Primadona, Yin-Hung Lai, Rey Y. Capangpangan, Rofeamor P. Obena, Mei-Chun Tseng, Ming-Feng Huang, Huan-Tsung Chang, Shiou-Ting Li, Chung-Yi Wu, Wei-Ting Chien, Chun-Cheng Lin, Yi-Sheng Wang*, Yu-Ju Chen* Functionalized HgTe Nanoparticles Promote Laser-Induced Solid Phase Ionization/Dissociation for Comprehensive Glycan Sequencing . ANALYST 2016-08, 141, 6093-6103.
Tsung-Che Chang, Avijit K. Adak, Ting-Wei Lin, Pei-Jhen Li, Yi-Ju Chen, Chain-Hui Lai, Chien-Fu Liang, Yu-Ju Chen, Chun-Cheng Lin* A photo-cleavable biotin affinity tag for the facile release of a photo-crosslinked carbohydrate-binding protein. BIOORGANIC & MEDICINAL CHEMISTRY 2016-03-15, 24(6), 1216-1224.
Sui-Chih Tien, Hsiao-Hui Lee, Ya-Chi Yang, Miao-Hsia Lin, Yu-Ju Chen, Zee-Fen Chang* The Shp2-Induced Epithelial Disorganization Defect is Reversed by HDAC6 Inhibition Independent of Cdc42. NATURE COMMUNICATIONS 2016-01, 7:10420.
Wai-Kok Choong, Hui-Yin Chang, Ching-Tai Chen, Chia-Feng Tsai, Wen-Lian Hsu, Yu-Ju Chen, Ting-Yi Sung Informatics View on the Challenges of Identifying Missing Proteins From Shotgun Proteomics. JOURNAL OF PROTEOME RESEARCH 2015-11, 14, 5396−5407.
Baby Rorielyn Dimayacyac-Esleta, Chia-Feng Tsai, Reta Birhanu Kitata, Pei-Yi Lin, Wai Kok Choong, Tai-Du Lin, Yi-Ting Wang, Shao-Hsing Weng, Pan-Chyr Yang, Susan Arco, Ting-Yi Sung, Yu-Ju Chen* Rapid High-pH Reverse Phase StageTip for Sensitive Small-Scale Membrane Proteomic Profiling. ANALYTICAL CHEMISTRY 2015-11, 87 (24), 12016–12023.
Kai-Ming Liu, Yi-Ju Chen, Li-Fen Shen, Amir N.S. Haddad, I-Wen Song, Li-Ying Chen, Yu-Ju Chen, Jer-Yuarn Wu, Jeffrey J.Y. Yen, Yuan-Tsong Chen* Cyclic Alopecia and Abnormal Epidermal Cornification in Zdhhc13-Deficient Mice Reveal the Importance of Palmitoylation in Hair and Skin Differentiation. JOURNAL OF INVESTIGATIVE DERMATOLOGY 2015-11, 135 (11), 2603-10.
Rey Y. Capangpangan, Mira Anne C. dela Rosa, Rofeamor P. Obena,Yu-Jen Chou, Der-Lii Tzou, Shao-Ju Shih, Ming-Hsi Chiang, Chun-Cheng Lin*, Yu-Ju Chen* Monodispersity of Magnetic Immuno-Nanoprobes Enhances the Detection Sensitivity of Low Abundance Biomarkers in One Drop of Serum. ANALYST 2015-09, 140, 7678–7686.
Hsin-Yi Wu, Yih-Gang Goan, Ying-Hua Chang, Yi-Fang Yang, Hsiao-Jen Chang, Pin-Nan Cheng, Chih-Chieh Wu, Victor Zgoda, Yu-Ju Chen*, Pao-Chi Liao Qualification and Verification of Serological Biomarker Candidates for Lung Adenocarcinoma by Targeted Mass Spectrometry. JOURNAL OF PROTEOME RESEARCH 2015-08, 14(8), 3039-3050.
Horvatovich Péter, Lundberg Emma, Yu-Ju Chen, Ting-Yi Sung, Fuchu He, Edouard Nice, Robert Goode, Simon Yu, Shoba Ranganathan, Mark Baker, Gilberto Domont, Erika Velasquez, Dong Li, Siqi Liu, Quanhui Wang, Qing-Yu He, Rajasree Menon, Yuanfang Guan, Fern A Quest for Missing Proteins: Update 2015 on Chromosome-Centric 2 Human Proteome Project. JOURNAL OF PROTEOME RESEARCH 2015-07, DOI: 10.1021/pr5013009.
Kitata Reta Birhanu, Dimayacyac-Esleta Baby Rorielyn, Choong Wai-Kok, Chia-Feng Tsai, Tai-Du Lin, Chih-Chiang Tsou, Shao-Hsing Weng, Yi-Ju Chen, Pan-Chyr Yang, Arco Susan, Nesvizhskii Alexey, Ting-Yi Sung, Yu-Ju Chen* Mining Missing Membrane Proteins by High-pH Reverse Phase StageTip Fractionation and Multiple Reaction Monitoring Mass Spectrometry. JOURNAL of PROTEOME RESEARCH 2015-07, DOI: 10.1021/acs.jproteome.5b00477.
Horvatovich Péter, Lundberg Emma, Yu-Ju Chen, Ting-Yi Sung, Fuchu He, Edouard Nice, Robert Goode, Simon Yu, Shoba Ranganathan, Mark Baker, Gilberto Domont, Erika Velasquez, Dong Li, Siqi Liu, Quanhui Wang, Qing-Yu He, Rajasree Menon, Yuanfang Guan, Fern Quest for Missing Proteins: Update 2015 on Chromosome-Centric 2 Human Proteome Project. JOURNAL OF PROTEOME RESEARCH 2015-07, 14(9), 3415-31.
Rofeamor P. Obena, Mei-Chun Tseng, Indah Primadona, Jun Hsiao, I.-Che Li, Rey Y. Capangpangan, Hsiu-Fong Lu, Wan-Sheung Li, Ito Chao, Chun-Cheng Lin, Yu-Ju Chen* UV-Activated Multi-Layer Nanomatrix Provides Onestep Tunable Carbohydrate Structural Characterization in MALDI-MS. CHEMICAL SCIENCE 2015-05, 6, 4790-4800.
Einav Amit, Rofeamor Palarca Obena, Yi-Ting Wang, Roman Zhuravel, Aaron Reyes, Shir Elbaz, Dvir Rotem, Danny Porath, Assaf Friedler, Yu-Ju Chen, Shlomo Yitzchaik Integrating Proteomics with Electrochemistry for Identifying Kinase Biomarkers. CHEMICAL SCIENCE 2015-05, 6, 4756-4766.
Yi-Ju Chen, Cheng-Tsung Lu, Kai-Yao Huang, Hsin-Yi Wu, Yu-Ju Chen*, Tzong-Yi Lee* GSHSite: Exploiting An Iteratively Statistical Method to Identify S-Glutathionylation Sites with Substrate Specificity. PLoS One 2015-04, 10(4):e0118752. doi: 10.1371/journal.pone.0118752.
Hsin-Yung Yen, Ying-Chih Liu, Nai-Yu Chen, Chia-Feng Tsai, Yi-Ting Wang, Yu-Ju Chen, Tsui-Ling Hsu, Pan-Chyr Yang, Chi-Huey Wong* Effect of Sialylation on EGFR Phosphorylation and Resistance to Tyrosine Kinase Inhibition. PNAS 2015-04, 112 (22), 6955-6960.
Chia-Feng Tsai, Yi-Ting Wang, Hsin-Yung Yen, Chih-Chiang Tsou, Wei-Chi Ku, Pei-Yi Lin, Hsuan-Yu Chen, Alexey Nesvizhskii, Yasushi Ishihama*, Yu-Ju Chen* Large-Scale Determination of Absolute Phosphorylation Stoichiometries in Human Cells by Motif-Targeting Quantitative Proteomics. NATURE COMMUNICATIONS 2015-03, 6:6622 | DOI: 10.1038/ncomms7622.
Ke-Shiuan Lynn, Chen-Chun Chen, T. Mamie Lih, Cheng-Wei Cheng, Wan-Chih Su, Chun-Hao Chang, Chia-Ying Cheng, Wen-Lian Hsu, Yu-Ju Chen*, Ting-Yi Sung* MAGIC: An Automated N-Linked Glycoprotein Identification Tool Using a Y1-Ion Pattern Matching Algorithm and in Silico MS2 Approach. ANALYTICAL CHEMISTRY 2015-01-16, 87 (4), 2466-2473.
Hsin-Yi Wu, Cheng-Tsung Lu, Hui-Ju Kao, Yi-Ju Chen, Yu-Ju Chen*, Tzong-Yi Lee* Characterization and Identification of Protein O-GlcNAcylation Sites with Substrate Specificity. BMC BIOINFORMATICS 2014-12, 15, S1.
Yi-Ju Chen, Cheng-Tsung Lu, Min-Gang Su, Kai-Yao Huang, Wei-Chieh Ching, Hsiao-Hsiang Yang, Yen-Chen Liao, Yu-Ju Chen, Tzong-Yi Lee* DbSNO 2.0: A Resource for Exploring Structural Environment, Functional and Disease Associations, and Regulatory Networks of Protein S-Nitrosylation. NUCLEIC ACIDS RESEARCH 2014-11, 43, Database issue D503–D511 doi: 10.1093/nar/gku1.
Ching-Wen Chang, Yu-Syuan Chen, Shiu-Huey Chou, Chia-Li Han, Yu-Ju Chen, Cheng-Chieh Yang, Chih-Yang Huang*, Jeng-Fan Lo* Distinct Subpopulations of Head and Neck Cancer Cells with Different Levels of Intracellular Reactive Oxygen Species Exhibit Diverse Stemness, Proliferation, and Chemosensitivity. CANCER RESEARCH 2014-09, DOI: 10.1158/0008-5472.CAN-14-0626.
Min-Gang Su, Chien-Hsun Huang, Tzong-Yi Lee, Yu-Ju Chen*, Hsin-Yi Wu* Incorporating Amino Acids Composition and Functional Domains for Identifying Bacterial Toxin Proteins. BioMed Research International 2014-07, 2014, 972692.
Cheng-Tsung Lu, Tzong-Yi Lee, Yu-Ju Chen*, Yi-Ju Chen* An Intelligent System for Identifying Acetylated Lysine on Histones and Nonhistone Proteins. BioMed research International 2014-07, 528650.
S-H Kao, W-L Wang, C-Y Chen, Y-L Chang, Y-Y Wu, Y-T Wang, S-P Wang, AI Nesvizhskii, Y-J Chen, T-M Hong*, P-C Yang* GSK3β Controls Epithelial-Mesenchymal Transition and Tumor Metastasis by CHIP-Mediated Degradation of Slug. ONCOGENE 2014-06, doi:10.1038/onc.2013.279.
Wei-Ting Chien, Chien-Fu Liang, Ching-Ching Yu, Chien-Hung Lin, Si-Peng Li, Indah Primadona, Yu-Ju Chen, Kwok Kong T. Mong, Chun-Cheng Lin* Sequential One-Pot Enzymatic Synthesis of Oligo-N-Acetyllactosamine and Its Multi-Sialylated Extensions. CHEMICAL COMMUNICATIONS 2014-06, 50, 5786-5789.
Chih-Ming Tsai, Hsin-Yi Wu, Tseng-Hsiung Su, Chu-Wei Kuo, Han-Wen Huang, Cheng-Han Chung, Chien-Sin Chen, Kay-Hooi Khoo, Yu-Ju Chen*, Kuo-I Lin* Phosphoproteomic Analyses Reveal that Galectin-1 Augments the Dynamics of B-Cell Receptor Signaling. JOURNAL OF PROTEOMICS 2014-05, 103, 241-253.
Yi-Ju Chen, Cheng-Tsung Lu,Tzong-Yi Lee*, Yu-Ju Chen* DbGSH: A Database of S-Glutathionylation. BIOINFORMATICS 2014-04, 30(16):2386-2388, 10.1093/bioinformatics/btu301.
Kai-Yao Huang, Hsin-Yi Wu, Yi-Ju Chen, Cheng-Tsung Lu, Min-Gang Su, Yun-Chung Hsieh, Chih-Ming Tsai, Kuo-I Lin, Hsien-Da Huang, Tzong-Yi Lee*, Yu-Ju Chen* RegPhos 2.0: An Updated Resource to Explore Protein Kinase-Substrate Phosphorylation Networks in Mammals. JOURNAL OF PROTEOMICS 2014-03, 2014(0):bau034. doi: 10.1093/database/bau034.
I-Wen Song, Wei-Ru Li, Li-Ying Chen, Li-Fen Shen, Kai-Ming Liu, Jeffrey J. Y. Yen, Yi-Ju Chen, Yu-Ju Chen, Virginia Byers Kraus, Jer-Yuarn Wu, M. T. Michael Lee, Yuan-Tsong Chen* Palmitoyl Acyltransferase, Zdhhc13, Facilitates Bone Mass Acquisition by Regulating Postnatal Epiphyseal Development and Endochondral Ossification: A Mouse Model. PLoS One 2014-03, 9 (3),e92194.
Wen-Lung Wang, Hsiao-Chun Huang, Shih-Han Kao, Yi-Chiung Hsu, Yi-Ting Wang ,Ker- Chau Li , Yu-Ju Chen, Sung-Liang Yu, Shu-Ping Wang, Tzu-Hung Hsiao, Pan-Chyr Yang and Tse-Ming Hong* Slug is Temporally Regulated by Cyclin E in Cell Cycle and Controls Genome Stability. ONCOGENE 2014-03, doi: 10.1038/onc. 2014. 58, 1–10.
Yi-Ju Chen, Wei-Chieh Ching, Jinn-Shiun Chen, Tzong-Yi Lee, Cheng-Tsung Lu, Hsiao-Chiao Chou, Pei-Yi Lin, Kay-Hooi Khoo, Jenn-Han Chen, Yu-Ju Chen* Decoding the S‑Nitrosoproteomic Atlas in Individualized Human 2 Colorectal Cancer Tissues Using a Label-Free Quantitation Strategy. JOURNAL OF PROTEOME RESEARCH 2014-03, 13(11), 4942–4958.
Wan-Jiun Chen, Chao-Chi Ho, Yih-Leong Chang, Hsuan-Yu Chen, Chih-An Lin, Thai-Yen Ling, Sung-Liang Yu, Shin-Sheng Yuan, Yu-Ju Louisa Chen, Chien-Yu Lin, Szu-Hua Pan, Han-Yi Elizabeth Chou,Yu-Ju Chen,Gee-Chen Chang, Wen-Cheng Chu, Yee-Ming Lee, Jen-Yi Le Cancer-Associated Fibroblasts Regulate the Plasticity of Lung Cancer Stemness via Paracrine Signalling. Nature Communications 2014-03, 5:3472, DOI: 10.1038/ncomms4472.
Yi-Ju Chen, Wei-Chieh Ching, Yu-Pei Linc, Yu-Ju Chen* Methods for Detection and Characterization of Protein S-nitrosylation. METHODS 2014-02, 62 (2), 138-150.
Li Kao, Yi-Ting Wang, Yu-Chen Chen, Shun-Fu Tseng, Jia-Cin Jhang, Yu-Ju Chen*, Shu-Chun Teng Global Analysis of Cdc14 Dephosphorylation Sites Reveals Essential Regulatory Role in Mitosis and Cytokinesis. MOLECULAR & CELLULAR PROTEOMICS 2014-02, 13(2), 594-605.
Chia-Feng Tsai, Chuan-Chih Hsu, Jo-Nan Hung, Yi-Ting Wang, Wai-Kok Choong, Ming-Yao Zeng, Pei-Yi Lin, Ruo-Wei Hong, Ting-Yi Sung, Yu-Ju Chen* Sequential Phosphoproteomic Enrichment through Complementary Metal-directed Immobilized Metal Ion Affinity Chromatography. ANALYTICAL CHEMISTRY 2014-01, 86 (1), pp 685–693.
Yu-Wang Chang, Ya-Ting Chang, Qinchuan Wang, Jim Jung-Ching Lin, Yu-Ju Chen, Chien-Chang Chen* Quantitative Phosphoproteomic Study of Pressure-Overloaded Mouse Heart Reveals Dynamin-Related Protein 1 as a Modulator of Cardiac Hypertrophy. MOLECULAR & CELLULAR PROTEOMICS 2013-11, 12(11), 3094-3107.
Su-Chien Chiang, Chia-Li Han, Kun-Hsing Yu, Yu-Ju Chen, Kun-Pin Wu* Prioritization of Cancer Marker Candidates Based on The Immunohistochemistry Staining Images Deposited in The Human Protein Atlas. PLoS One 2013-11, 8(11): e81079.
Chen-Chun Chen, Wan-Chih Su, Bao-Yu Huang, Yu-Ju Chen, Hwan-Ching Tai*, Rofeamor Palarca Obena* Interaction Modes and Approaches to Glycopeptide and Glycoprotein Enrichment. ANALYST 2013-11, 139 (4), 688-704.
Teng-Kuei Huang, Chia-Li Han, Shu-I Lin, Yu-Ju Chen, Yi-Chuan Tsai, Yet-Ran Chen, June-Wei Chen,Wei-Yi Lin, Pei-Mien Chen, Tzu-Yin Liu, Ying-Shin Chen, Ching-Mei Sun, Tzyy-Jen Chiou* Identification of Downstream Components of Ubiquitin-Conjugating Enzyme PHOSPHATE2 by Quantitative Membrane Proteomics in Arabidopsis Roots. THE PLANT CELL 2013-10, tpc.113.115998.
Tsung-Che Chang, Chian-Hui Lai, Chih-Wei Chien, Chien-Fu Liang, Avijit Kumar Adak, Yung-Jen Chuang, Yu-Ju Chen, Chun-Cheng Lin* Synthesis and Evaluation of a Photoactive Probe with a Multivalent Carbohydrate for Capturing Carbohydrate−Lectin Interactions. BIOCONJUGATE CHEMISTRY 2013-10, 24 (11),1895-1906.
Yi-Hsuan Wu, Chia-Wei Hu, Chih-Wei Chien, Yu-Ju Chen,Hsuan-Cheng Huang*, Hsueh-Fen Juan* Quantitative Proteomic Analysis of Human Lung Tumor Xenografts Treated with the EctopicATP Synthase Inhibitor Citreoviridin. PLoS One 2013-08, 8(8): e70642. doi:10.1371/journal.pone.0070642.
Ying-Wei Lu, Chih-Wei Chien, Po-Chiao Lin, Li-De Huang, Chang-Yang Chen, Sz-Wei Wu,Chia-Li Han, Kay-Hooi Khoo, Chun-Cheng Lin*, Yu-Ju Chen* BAD-Lectins: Boronic Acid-Decorated Lectins with Enhanced Binding Affinity for the Selective Enrichment of Glycoproteins. ANALYTICAL CHEMISTRY 2013-07, 85 (17), 8268–8276.
Chia-Wei Hu, Chien-Wei Tseng, Chih-Wei Chien, Hsuan-Cheng Huang, Wei-Chi Ku, Shyh-Jye Lee, Yu-Ju Chen*, Hsueh-Fen Juan* Quantitative Proteomics Reveals Diverse Roles of miR-148a from Gastric Cancer Progression to Neurological Development. JOURNAL OF PROTEOME RESEARCH 2013-07, 12(9), pp 3993–4004.
Chia-Ying Cheng, Chia-Feng Tsai, Yu-Ju Chen, Ting-Yi Sung*, Wen-Lian Hsu Spectrum-based Method to Generate Good Decoy Libraries for Spectral Library Searching in Peptide Identifications. JOURNAL OF PROTEOME RESEARCH 2013-05, 12 (5), 2305-2310.
Cheng-An Wang, Wei-Ta Chen, Ho-Shun Cheng, Cheng-Chih Chung, Yu-Ju Chen, Ming-Hsiung Hsieh* Thyroid Storm and Incidental Anterior Mediastinal Teratoma: Coincidence or Correlation?. Acta Cardiological Sinica 2013-04, 29:467470.
Cheng-Chih Chung, Yu-Hsun Kao, Yu-Ju Chen, Yi-Jen Chen* Androgen Modulates Cardiac Fibrosis Contributing to Gender Differences on Heart Failure. AGING MALE 2013-03, 16 (1), 22-27.
Lien-Chin Chen, Mei-Ying Liu, Yung-Chin Hsiao, Wai-Kok Choong, Hsin-Yi Wu, Wen-Lian Hsu, Pao-Chi Liao*, Ting-Yi Sung*, Shih-Feng Tsai*, Jau-Song Yu*, Yu-Ju Chen* Decoding the Disease-Associated Proteins Encoded in The Human Chromosome 4. JOURNAL OF PROTEOME RESEARCH 2013-01, 12 (1), 33–44.
Cheng-Tsung Lu, Kai-Yao Huang, Min-Gang Su, Tzong-Yi Lee*, Neil Arvin Bretana, Wen-Chi Chang, Yi-Ju Chen, Yu-Ju Chen, Hsien-Da Huang* DbPTM 3.0: An Informative Resource for Investigating Substrate Site Specificity and Functional Association of Protein Post-Translational Modifications. NUCLEIC ACIDS RESEARCH 2013-01, 41(D1): D295-D305.
Po-Chiao Lin*, Ching-Ching Yu, Huan-Ting Wu,Ying-Wei Lu, Chia-Li Han, An-Kai Su, Yu-Ju Chen*, Chun-Cheng Lin* A Chemically Functionalized Magnetic Nanoplatform for Rapid and Specific Biomolecular Recognition and Separation. BIOMACROMOLECULES 2013-01, 14 (1), pp 160–168.
Jennifer Ho*, Oscar Lee, Yun-Ju Fu, Hung-Ta Shih, Chien-Yu Tseng, Cheng-Chih Chung, Chia-Li Han, Yu-Ju Chen* An iTRAQ Proteomic Study Reveals an Association between Diet-induced Enhanced Fatty-acid Metabolism and the Development of Glucose Intolerance in Prediabetic Mice. JOURNAL OF PROTEOME RESEARCH 2013-01, 12 (3), pp1120-1133.
Chen-Chun Chen, Wan-Chih Su, Bao-Yu Huang, Yu-Ju Chen, Hwan-Ching Tai, Rofeamor Palarca Obena Interaction Modes and Approaches to Glycopeptide and Glycoprotein Enrichment. ANALYST 2013, 139 (4), 688-704.
Tzong-Yi Lee*, Yi-Ju Chen, Cheng-Tsung Lu, Wei-Chieh Ching, Yu-Chuan Teng, Hsien-Da Huang, Yu-Ju Chen* DbSNO: a Database of Cysteine S-Nitrosylation. BIOINFORMATICS 2012-09, 28, 2293-2295.
Alan Chuan-Ying Lai, Chia-Feng Tsai, Chuan-Chih Hsu, Yu-Ni Sun, Yu-Ju Chen* Complementary Fe3+- and Ti4+-Immobilized Metal Ion Affinity Chromatography for Purification of Acidic and Basic Phosphopeptides. RAPID COMMUNICATIONS IN MASS SPECTROMETRY 2012-09, 26, 2186-2194.
Chun-Mei Hu, Ming-Tyng Yeh, Chih-Wei Chen, Ning Tsao, Quan-Ze Gao, Chia-Yun Chang, Ming-Hsiang Lee, Jim-Min Fang, Sheh-Yi Sheu, Chow-Jaw Lin, Mei-Chun Tseng, Yu-Ju Chen, Zee-Fen Chang* Tumor cells require thymidylate kinase to prevent dUTP incorporation during DNA repair. CANCER CELL 2012-07, 22 (1) ,36-50.
Ting Lo, Chia-Feng Tsai, Yu-Ru V. Shih, Yi-Ting Wang, Sheng-Chieh Lu, Ting-Yi Sung, Wen-Lian Hsu, Yu-Ju Chen*, and Oscar K. Lee Phosphoproteomic Analysis of Human Mesenchymal Stromal Cells during Osteogenic Differentiation. JOURNAL OF PROTEOME RESEARCH 2012-02, 10,1021.
Obena Rofeamor, Lin Po-Chiao, Lu Ying-Wei, Li I-Che, del Mundo Florian, Arco Susan, Nuesca Guillermo, Lin Chun-Cheng, Chen Yu-Ju* Iron Oxide Nanomatrix Facilitates Metal Ionization in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry. ANALYTICAL CHEMISTRY 2011-11, 83(24), 9337-9343.
Tzu-Chi Chou, Wei Hsu, Ching-Ho Wang, Yu-Ju Chen*, Jim-Min Fang* Rapid and Specific Influenza Virus Detection by Functionalized Magnetic Nanoparticles and Mass Spectrometry. JOURNAL OF NANOBIOTECHNOLOGY 2011-11, 9(52),1477-3155.
Young-Eun Cho, Thoudam S.K. Singh, Hyun-Chul Lee, Pyong-Gon Moon, Jeong-Eun Lee, Myung-Hoon Lee, Eung-Chil Choi, Yu-Ju Chen, Sang-Hyun Kim, Moon-Chang Baek* In-Depth Identification of Pathways Related to Cisplatin-Induced Hepatotoxicity Through an Integrative Method Based on An Informatics-Assisted Label-Free Protein Quantitation and Microarray Gene Expression Approach. MOLECULAR & CELLULAR PROTEOMICS 2011-10, 10, 1074.
Hsin-Fu Chen, Ching-Yu Chuang, Wen-Chih Lee, Hsiang-Po Huang, Han-Chung Wu, Hong-Nerng Ho, Yu-Ju Chen and Hung-Chih Kuo* Surface Marker Epithelial Cell Adhesion Molecule and E-Cadherin Facilitate the Identification and Selection of Induced Pluripotent Stem Cells. Stem Cell Reviews and Reports 2011-09, 7, 722-735.
Huan-Ting Wu, Chuan-Chih Hsu, Chia-Feng Tsai, Po-Chiao Lin, Chun-Cheng Lin*, and Yu-Ju Chen* Nanoprobe-Based Immobilized Metal Affinity Chromatography for Sensitive and Complementary Enrichment of Multiply Phosphorylated Peptides. PROTEOMICS 2011-07, 13,11.
Tzong-Yi Lee*, Yi-Ju Chen, Tsung-Cheng Lu, Hsien-Da Huang and Yu-Ju Chen* SNOSite: Exploiting Maximal Dependence Decomposition to Identify Cysteine S-Nitrosylation with Substrate Site Specificity. PLoS One 2011-07, 6(7),1-11.
Pei-Yi Cheng, Yu-Ping Lin, Ya-Ling Chen, Yi-Ching Lee, Chia-Chen Tai, Yi-Ting Wang, Yu-Ju Chen, Cheng-Fu Kao*, John Yu* Interplay Between SIN3A and STAT3 Mediates Chromatin Conformational Changes and GFAP Expression During Cellular Differentiation. PLoS One 2011-07, 6, 1-15.
Putty-Reddy Sudhir, Chia-Lang Hsu, Mei-Jung Wang, Yi-Ting Wang, Yu-Ju Chen, Ting-Yi Sung, Wen-Lian Hsu, Ueng-Cheng Yang, Jeou-Yuan Chen Phosphoproteomics Identifies Oncogenic Ras Signaling Targets and Their Involvement in Lung Adenocarcinomas. PLoS One 2011-05, 6, 1-10.
Chung-Wei Fan,Chung-Chuan Chan,Kuei-Tien Chen,Jen Twu,Ya-Shu Huang,Chia-Li Han,Yu-Ju Chen,Jau-Song Yu,Yu-Sun Chang,Yung-Bin Kuo,Err-Cheng Chan* Identification of SEC61 Beta and Its Autoantibody As Biomarkers for Colorectal Cancer. CLINICA CHIMICA ACTA 2011-05, 412 (11-12), 887–893.
Chia-Li Han, Jinn-Shiun Chen, Err-Cheng Chan, Chien-Peng Wu, Kun-Hsing Yu, Kuei-Tien Chen, Chih-Chiang Tsou, Chia-Feng Tsai, Chih-Wei Chien, Yung-Bin Kuo, Pei-Yi Lin, Jau-Song Yu, Chuen Hsueh, Min-Chi Chen, Chung-Chuan Chan, Yu-Sun Chang, Yu-Ju Chen* An Informatics-assisted Label-free Approach for Personalized Tissue Membrane Proteomics: Case Study on Colorectal Cancer. MOLECULAR & CELLULAR PROTEOMICS 2011-04, 10,1-15.
Yi-Chi Ho, Mei-Chun Tseng, Ying-Wei Lu, Chun-Cheng Lin, Yu-Ju Chen*, Ming-Ren Fuh* Nanoparticle-assisted MALDI-TOF MS combined with Seed-Layer Surface Preparation for Quantification of Small Molecules. ANALYTICA CHIMICA ACTA 2011-04, 697, 1-7.
Yi-Ju Chen, Wei-Chi Ku, Pei-Yi Lin, Hsiao-Chiao Chou, Kay-Hooi Khoo, and Yu-Ju Chen* S-Alkylating Labeling Strategy for Site-Specific Identification of The S-Nitrosoproteome. JOURNAL OF PROTEOME RESEARCH 2010-12, 9, 6417–6439.
Lifeng Peng, Eugene A. Kapp, David Fenyö, Min-Seok Kwon, Pu Jiang, Songfeng Wu, Ying Jiang, Marie-Isabel Aguilar, Nikhat Ahmed, Mark S. Baker, Zongwei Cai, Yu-Ju Chen, Phan Van Chi, Maxey C. M. Chung, Fuchu He, Alice C. L. Len, Pao-Chi Liao, Kazuyuki Naka The Asia Oceania Human Proteome Organisation Membrane Proteomics Initiative. Preparation and characterisation of the carbonate-washed membrane standard. PROTEOMICS 2010-11, 10, 4142–4148.
Mei-Chun Tseng, Rofeamor Obena, Ying-Wei Lu, Po-Chiao Lin, Ping-Yu Lin, Yung-Sheng Yen, Jiann-Tsuen Lin, Li-De Huang, Kuang-Lieh Lu, Long-Li Lai, Chun-Cheng Lin, Yu-Ju Chen* Dihydrobenzoic Acid Modified Nanoparticle as a MALDI-TOF MS Matrix for Soft Ionization and Structure Determination of Small Molecules with Diverse Structures. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY 2010-11, 21, 1930–1939.
Wang, Yi-Ting,Tsai, Chia-Feng, Hong Tzu-Chan, Tsou, Chih-Chiang, Lin, Pei-Yi, Pan, Szu-Hua, Hong, Tse-Ming, Yang, Pan-Chyr, Sung, Ting-Yi, Hsu Wen-Lian, Chen, Yu-Ju An Informatics-assisted Label-free Quantitation Strategy that Depicts Phosphoproteomic Profiles in Lung Cancer Cell Invasion. JOURNAL OF PROTEOME RESEARCH 2010-09, 9, 5582–5597.
Jinn-Shiun Chen, Kuei-Tien Chen, Chung-Wei Fan, Chia-Li Han, Yu-Ju Chen, Jao-Song Yu, Yu-Sun Chang, Chih-Wei Chien, Chien-Peng Wu, Ray-Ping Hung, Err-Cheng Chan* Comparison of Membrane Fraction Proteomic Profiles of Normal and Cancerous Human Colorectal Tissues with Gel-assisted Digestion and iTRAQ Labeling Mass Spectrometry. FEBS JOURNAL 2010-07, 277, 3028–3038.
Shyh-Horng Chiou, Chun-Hao Huang, I-Liang Lee, Yi-Ting Wang, Nai-Yu Liu, Yeou-Guang Tsay, and Yu-Ju Chen Identification of In Vivo Phosphorylation Sites of Lens Proteins From Porcine Eye Lenses By A Gel-Free Phosphoproteomics Approach. MOLECULAR VISION 2010-02, 16, 294–302.
Shu-Ling Lin, Chih-Wei Chien, Chia-Li Han, Eric S.-W. Chen, Shao-Hsuan Kao, Yu-Ju Chen and Fang Liao Temporal Proteomics Profiling of Lipid Rafts in CCR6-Activated T Cells Reveals the Integration of Actin Cytoskeleton Dynamics. JOURNAL OF PROTEOME RESEARCH 2010-01, 9 (1), 283–297.
Chih-Chiang Tsou, Chia-Feng Tsai, Ying-Hao Tsui, Putty-Reddy Sudhir, Yi-Ting Wang, Yu-Ju Chen, Jeou-Yuan Chen, Ting-Yi Sung, and Wen-Lian Hsu IDEAL-Q, an Automated Tool for Label-free Quantitation Analysis Using an Efficient Peptide Alignment Approach and Spectral Data Validation. MOLECULAR & CELLULAR PROTEOMICS 2010-01, 9, 131 - 144..
Po-Chiao Lin, Shu-Hua Chen, Kai-Yi Wang, Mu-Lin Chen, Avijit Kumar Adak, Jih-Ru R. Hwu, Yu-Ju Chen,*| and Chun-Cheng Lin* Fabrication of Oriented Antibody-Conjugated Magnetic Nanoprobes and Their Immunoafﬁnity Application. ANALYTICAL CHEMISTRY 2009-10, 81 (21), 8774–8782.
Ta-Wei Liu, Ching-Wen Ho, Hsing-Hung Huang, Sue-Ming Chang, Shide S. Popat, Yi-Ting Wang, Ming-Shiang Wu, Yu-Ju Chen*, and Chun-Hung Lin Role for L-Fucosidase in the Contro; of Helicobacter pylori-infected Gastric Cancer Cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2009-08, 106, 14581-14586.
Chih-Chiang Tsou, Yin-Hao Tsui, Yi-Hwa Yian, Yi-Ju Chen, Han-Yin Yang, Chuan-Yih Yu, Ke-Shiuan Lynn, Yu-Ju Chen, Ting-Yi Sung,* and Wen-Lian Hsu,* MaXIC-Q Web: A Fully Automated Web Service Using Statistical and Computational Methods for Protein Quantitation Based on Stable Isotope Labeling and LC–MS. NUCLEIC ACIDS RESEARCH 2009-06, 37(2), 661-669.
Wei-Chi Ku, Sung-Kay Chiu, Yi-Ju Chen, Hsin-Hung Huang, Wen-Guey Wu, and Yu-Ju Chen* Complementary Quantitative Proteomics Reveals that Transcription Factor AP-4 Mediates E-Box-Dependent Complex Formation for Transcriptional Repression of HDM2. MOLECULAR & CELLULAR PROTEOMICS 2009, 8, 2034-2050.
Chia-Li Han, Chih-Wei Chien, Wen-Cheng Chen, Yet-Ran Chen, Chien-Peng Wu, Hung Li, and Yu-Ju Chen* A Multiplexed Quantitative Strategy for Membrane Proteomics: Opportunities for Mining Therapeutic Targets for Autosomal-Dominant Polycystic Kidney Disease. MOLECULAR & CELLULAR PROTEOMICS 2008, 7, 1983–1997.
Chia-Feng Tsai, Yi-Ting Wang, Yet-Ran Chen, Chen-Yu Lai, Pei-Yi Lin, Kuan-Ting Pan, Jeou-Yuan Chen, Kay-Hooi Khoo, and Yu-Ju Chen* Immobilized Metal Affinity Chromatography Revisited: pH/acid Control toward High Selectivity in Phosphoproteomics. JOURNAL OF PROTEOME RESEARCH 2008, 7, 4058-4069.
Yen-Ta Lu, Chia-Li Han, Chien-Liang Wu, Tien-Min Yu, Chih-Wei Chien, Ching-Lung Liu and Yu-Ju Chen* Proteomic Profiles of Bronchoalveolar Lavage Fluid from Patients with Ventilator- associated Pneumonia by Gel-assisted Digestion and 2DLC/MS/MS. PROTEOMICS 2008, 2, 1208-1212.
Kai-Yi Wang, Szu-An Chuang, Po-Chiao Lin, Li-Shing Huang, Shu-Hua Chen, Saib Ouarda, Wen-Harn Pan, Ping-Ying Lee, Chun-Cheng Lin*, and Yu-Ju Chen* Multiplexed Immunoassay: Quantitation and Profiling of Serum Biomarkers Using Magnetic Nanoprobes and MALDI-TOF MS. ANALYTICAL CHEMISTRY 2008, 80, 6159-6167.
Yuh-Yih Chien, Mi-Dan Jan, Avijit Kumar Adak, Hsiao-Chien Tzeng, Yen-Ping Lin, Yu-Ju Chen, Ken-Tseng Wang, Chien-Tien Chen, Chia-Chun Chen*, and Chun-Cheng Lin* Globotriose-Functionalized Gold Nanoparticles as Multivalent Probes for Shiga-like Toxin. CHEMBIOCHEM 2008, 9, 1100-1109.
Yi-Ju Chen, Wei-Chi Ku, Li-Ting Feng, Ming-Li Tsai, Chung-Hung Hsieh, Wen-Hwei Hsu, Wen-Feng Liaw, Chen-Hsiung Hung*, and Yu-Ju Chen* Nitric Oxide Physiological Responses and Delivery Mechanisms Probed by Water-soluble Roussin’s Red Ester and{Fe(NO)2}10 DNIC. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2008, 130,10929-10938.
Shu-Hua Chen, Hsin-Kai Liao, Chih-Yang Chang, Chiun-Gung Juo, Jenn-Han Chen, Sunney I. Chan, and Yu-Ju Chen* Targeted Protein Quantitation and Profiling Using PVDF Affinity Probe and MALDI-TOF MS. PROTEOMICS 2007, 7, 3038–3050.
Po-Chiao Lin, Mei-Chun Tseng, An-Kai Su, Chun-Cheng Lin* and Yu-Ju Chen* Functionalized Magnetic Nanoparticles for Small Molecule Isolation, Identification and Quantification. ANALYTICAL CHEMISTRY 2007, 79, 3401-3408.
Tai-Chia Chiu, Li-Shing Huang, Po-Chiao Lin, Yu-Chie Chen*, Yu-Ju Chen*, Chun-Cheng Lin, and Huan-Tsung Chang* Nanomaterial Based Affinity Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry for Biomolecules and Pathogenic Bacteria. Recent Patents on Nanotechnology 2007, 1, 99-111.
De-Chuan Chan*, Cheng-Jueng Chen, Heng-Cheng Chu, Wei-Kuo Chang, Jyh-Cherng Yu, Yu-Ju Chen, Li-Li Wen, Su-Ching Huang, Chih-Hung Ku, Yao-Chi Liu and Jenn-Han Chen* Evaluation of Serum Amyloid A as a Biomarker for Gastric Cancer. ANNALS OF SURGICAL ONCOLOGY 2007, 14, 84-93.
Po-Chiao Lin, Shau-Hua Ueng, Mei-Chun Tseng, Jia-Ling Ko, Kuo-Ting Huang, Sheng- Chieh Yu, Avijit Kumar Adak, Yu-Ju Chen, and Chun-Cheng Lin* Site-specific Protein Modification through Cu-I-catalyzed 1,2,3-Triazole Formation and Its Implementation in Protein Microarray Fabrication. Angewandte Chemie (International Edition in English) 2006, 45(26), 4286-4290.
Po-Chiao Lin, Po-Hung Chou, Shu-Hua Chen, Hsin Kai Liao, Kai-Yi Wang, Yu-Ju Chen*, and Chun-Cheng Lin* Ethylene Glycol-Protected Magnetic Nanoparticles for Multiplexed Immunoassay in Human Plasma. SMALL 2006, 2(4), 485-489.
Chih-Yang Chang, Hsin-Kai Liao, Chiun-Gung Juo, Shu-Hua Chen, and Yu-Ju Chen* Improved Analysis of Membrane Protein by PVDF-Aided, Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry. ANALYTICA CHIMICA ACTA 2006, 556,237-246.
Yet-Ran Chen, Hsueh-Fen Juan, Hsuan-Cheng Huang , Hsin-Hung Huang, Ya-Jung Lee, Mei-Yueh Liao, Chien-Wei Tseng, Li-Ling Lin, Jeou-Yuan Chen, Mei-Jung Wang, Jenn-Han Chen,and Yu-Ju Chen* Quantitative Proteomic and Genomic Profiling Reveals Metastasis-Related Protein Expression Patterns in Gastric Cancer Cells. JOURNAL OF PROTEOME RESEARCH 2006, 5(10), 2727-2742.
Chiung-Cheng Huang, Ying-Chih Lin, Ping-Yu Lin, Yu-Ju Chen Star-shaped Molecules Containing Polyalkynyl Groups with Metal Moieties on Benzene and Triphenylene Cores. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2006, 19, 4510-4518.
Wen-Ting Lin, Wei-Neng Hung, Yi-Hwa Yian, Kun-Pin Wu*, Chia-Li Han, Yet-Ran Chen, Yu-Ju Chen, Ting-Yi Sung* and Wen-Lian Hsu Multi-Q: A Fully Automated Tool for Multiplexed Protein Quantitation. JOURNAL OF PROTEOME RESEARCH 2006, 5(9), 2328-2338.
Yuan-Chen Chang, Hsiao-Hui Lee, Yu-Ju Chen, Gary M. Bokoch, and Zee-Fen Chang* Contribution of Guanine Exchange Factor H1 in Phorbol Ester-induced Apoptosis. CELL DEATH AND DIFFERENTIATION 2006, 13, 2023-2032.
Hung-Yi Kao, Yi-Ning Su, Hsin-Kai Liao, Ming S. Liu, and Yu-Ju Chen* Determination of SMN1/SMN2 Gene Dosage by a Quantitative Genotyping Platform Combining Capillary Electrophoresis and MALDI-TOF Mass Spectrometry. CLINICAL CHEMISTRY 2006, 52, 361-369.
Hsin-Hung Huang, Hsin-Kai Liao, Tzann-Shun Hwang, Yi-Han Lin, Chun-Hung Lin and Yu-Ju Chen* Structural Characterization of Sialic Acid Synthase by Electrospray Mass Spectrometry- a Tetrameric Enzyme Composed of Dimeric Dimers. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY 2005, 16, 324-332.
Yu-Ju Chen*, Shu-Hua Chen, Yuh-Yih Chien, Yu-Wan Chang, Hsin-Kai Liao, Chih-Yang Chang, Mi-Dan Jan, Ken-Tseng Wang, and Chun-Cheng Lin* Carbohydrate-Encapsulated Gold Nanoparticles for Rapid Target Protein Identification and Binding Epitope Mapping. CHEMBIOCHEM 2005, 6, 1169-1173.
Po-Hung Chou, Shu-Hua Chen, Hsin-Kai Liao, Po-Chiao Lin, Gour-Rong Her, Alan Chuan-Ying Lai, Jenn-Han Chen, Chun-Cheng Lin*, and Yu-Ju Chen* Nanoprobe-Based Affinity Mass Spectrometry for Selected Protein Profiling in Human Plasma. ANALYTICAL CHEMISTRY 2005, 77, 5990-5997.
Lee-Chiang Lo*, Ying-Ling Chiang, Chi-Hsien Kuo, Hsin-Kai Liao, Yu-Ju Chen, and Jing-Jer Lin* Study of the Preferred Modification Sites of the Quinone Methide Intermediate Resulting from the Latent Trapping Device of the Activity Probes for Hydrolases. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2005, 326, 30-35.
Hsin-Yuan Cheng, Yu-Yu Lin, Chun-Ying Yu, Jen-Yau Chen, Kuo-Fang Shen, Wei-Ling Lin, Hsin-Kai Liao, Yu-Ju Chen, Chen-Hsuan Liu, Victor Fei Pang and Tzuu-Shuh Jou* Molecular Identification of Canine Podocalyxin-like Protein 1 as a Renal Tubulogenic Regulator. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 2005, 16, 1612-1622.
Hsin-Kai Liao, Yi-Ning Su, Hung-Yi Kao, Chia-Cheng Hung, Hsueh-Ting Wang and Yu-Ju Chen* Parallel Minisequencing Followed by Multiplex Matrix-assisted Laser Desorption/ Ionization Mass Spectrometry Assay for Beta-thalassemia Mutations. JOURNAL OF HUMAN GENETICS 2005, 50, 139-150.
Fang-Yuan Lee, Jiann-Jyh Huang, Yu-Ju Chen, Kuan-Jiuh Lin, Gene-Hsiang Lee, Shie-Ming Peng, Jih-Ru Hwu, and Kuang-Lieh Lu* Os(CO)2(η2-SC5H4N(O))(η2-SCSH4N): Structural Evidence for the Transformation of Pyridine-2-thione N-Oxide to Pyridine-2-thiolate in Osmium Complexes. JOURNAL OF ORGANOMETALLIC CHEMISTRY 2005, 690, 441-449.
Yu-Wang Chang, Shu-Hua Chen, Yu-Ju Chen Application of Mass Spectrometry in Clinical Proteomics. Formosan Journal of Medicine 2005, 9, 637-649.
ei-Chun Kao, Yat-Ren Chen, Eugene C. Yi, Hookeun Lee, Qiang Tian, Keh-Ming Wu, Shih-Feng Tsai, Steve S. -F. Yu, Yu-Ju Chen, Ruedi Aebersold, and Sunney I. Chan* Quantitative Proteomic Analysis of Metabolic Regulation by Copper Ions in Methylococcus Capsulatus (Bath). JOURNAL OF BIOLOGICAL CHEMISTRY 2004, 279, 51554-51560.
Jenn-Han Chen*, Yu-Wang Chang, Chen-Wen Yao, Tzong-Shi Chiueh, Su-Chin Huang, Ko-Yi Chien, An Chen, Feng-Yee Chang, Chi-Huey Wong, and Yu-Ju Chen* Plasma proteome of Severe Acute Respiratory Syndrome (SARS) analyzed by two-dimensional gel electrophoresis and mass spectrometry.. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2004, 101, 17039-17044.
Hsiao-Hui Lee, Chung-Liang Chien, Hsin-Kai Liao, Yu-Ju Chen and Zee-Fen Cheng* Nuclear Efflux of Heterogeneous Nuclear Ribonucleoprotein C1/C2 in Apoptotic Cells: A Novel Nuclear Export Dependent on Rho-Associated Kinase Activation. JOURNAL OF CELL SCIENCE 2004, 117, 5579-5589.
Tung-Kung Wu*, Chiao-Yin Huang, Cheng-Yu Ko, Cheng-Hsiang Chang, Yu-Ju Chen, and Hsin-Kai Liao Purification, Tandem Mass Characterization, and Inhibition Studies of Oxidosqualene- lanosterol Cyclase Enzyme from Bovine Liver. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 2004, 421, 42-53.
Po-Jui Chen, Hsueh-Ting Wang, Chien-Chung Cheng, and Yu-Ju Chen* Specific Recognition of DNA Bulge Structure by Matrix-assisted Laser Desorption/ Ionization Time-of-flight Mass Spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY 2004, 18, 609-616.
Hsueh-Fen Juan, Jenn-Han Chen*, Wei-Tse Hsu, Su-Ching Huang, Shui-Tein Chen, John Yi-Chung Lin, Yu-Wang Chang, Chih-Yin Chiang, Li-Li Wen, De-Chuan Chan, Yao-Chi Liu, Yu-Ju Chen* Identification of Tumor-associated Plasma Biomarkers Using Proteomic Techniques: From Mouse to Human. PROTEOMICS 2004, 4, 2766-2775.
Chen-Hsiung Hung*, Cheng-Yu Lin, Ping-Yu Lin, and Yu-Ju Chen Synthesis and Crystal Structure of Core-Modified Benziporphyrin: Thia-ρ- Benziporphyrin. TETRAHEDRON LETTERS 2004, 45, 129-132.
Steve S.-F Yu, Kelvin H.-C. Chen , Mandy Y.-H., Yane-Shih Wang, Chiu-Feng Tseng, Yu-Ju Chen, Ded-Shih Huang*, Sunney I. Chan* Production of High-Quality Particulate Methane Monooxygenase in High Yields from methylococcus capsulatus (bath) with a Hollow-Fiber Membrane Bioreactor. JOURNAL OF BACTERIOLOGY 2003, 185(5915-24).
Wei-Chun Huang-Fu, Kuo-Chan Hung, Po-Jui Chen, Wen-Jwu Wang, and Yu-Ju Chen* Mechanistic aspect of Co(HAPP)(TFA)2 in DNA bulge-specific recognition.. NUCLEIC ACIDS RESEARCH 2003, 31, 2227-2233.
Chien-Tai Ren, Chien-Sheng Chen, Yi-Ping Yu, Yow-Fu Tsai, Ping-Yu Lin, Yu-Ju Chen, Wei Zou, and Shih-Hsiung Wu* Synthesis of α-(2→5) Neu5Gc Oligomers. CHEMISTRY- A EUROPEAN JOURNAL 2003, 9, 1085-1095.
Yu-Ju Chen*, Hsin-Kai Liao Mass Spectrometry – Based Proteomics. CHEMISTRY 2003, 61,235-247.
Yu-Ju Chen, P. T. Fenn, Kai-Chung Lau, C. Y. Ng*, Chi-Kin Law, and Wai-Kee Li* Study of the Dissociation of CH3SCH3+ by Collisional Activation: Evidence of Nonstatistical Behavior. JOURNAL OF PHYSICAL CHEMISTRY A 2002, 106, 9729-9736.
Tzann-Shun Hwang, Chih-Hung Hung, Chin-Fen Teo, Guan-Ting Chen, Lee-Shang Chang, Sung-Fang Chen, Yu-Ju Chen*, Chun-Hung Lin* Structural Characterization of Escherichia Coli Sialic Acid Synthase. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2002, 295, 167-173.
Yu-Ju Chen, P. T. Fenn, and C. Y. Ng* Direct Identification of Product CH2SH+/CH3S+ Structures in the Dissociation of CH3CH2SH+ and CH3SCH3+ via Collisional Activation. CHEMICAL PHYSICS LETTERS 2001, 336, 105-108.
Shih-Hao Chen, Li-Kung Chu, Yu-Ju Chen, I-Chia Chen and Yuan-Pern Lee* Detection of ClCO with Time-resolved Fourier-transform Infrared Absorption Spectroscopy. CHEMICAL PHYSICS LETTERS 2001, 333, 365-370.
Yu-Ju Chen, Shiaw-Ruey Lin, and Yuan-Pern Lee* Observation of CH4 (v(2)=1 or v(4)=1) in the Reaction Cl + CH4 by Time-resolved Fourier-transform Absorption Spectroscopy. JOURNAL OF CHEMICAL PHYSICS 2001, 115, 6513-6521.
T. Rajendran, Bala Manimaran, Fang-Yuan Lee, Po-Jui Chen, Su-Ching Lin, Gene-Hsiang Lee, Shie-Ming Peng, Yu-Ju Chen*, and Kuang-Lieh Lu* Self-assembly of Tetrametallic Square [Re-4(CO)(12)Br-4(mu-pz)(4)] (pz = pyrazine) from [Re(CO)(4)Br(pz)]. A Mechanistic Approach. J. Chem. Soc., Dalton Transactions 2001, 22, 3346 -3351.
S. Stimson, Yu.-Ju Chen, M. Evans, C.-W. Hsu, P. Heimann, C.-L. Liao, and C. Y. Ng* Rotational-Resolved Pulsed Field Ionization Photoelectron Bands of H-2(+)(X-2 Sigma(+)(g), v(+) = 0, 2, 9, and 11) Using Multibunch Synchrotron Radiation . CHEMICAL PHYSICS LETTERS 1998, 289, 507-515.
P. T. Fenn, Yu-Ju Chen, S. Stimson, C. Y. Ng, Wai- Kee Li and N.L. Ma A study of Dissociation of CH3CH2SH+ by Collisional Activation: Evidence of Non-Statistical Behavior. JOURNAL OF CHEMICAL PHYSICS 1998, 108, 8020-8028.
P. T. Fenn, Yu-Ju Chen, S. Stimson, and C. Y. Ng* Dissociation of CH3SH+ by Collisional Activation: Evidence of Non-Statistical Behavior. JOURNAL OF PHYSICAL CHEMISTRY A 1997, 101, 6513-6522.
Yu-Ju Chen, P. T. Fenn, and C. Y. Ng* Bond Selective Dissociation of CH3SH+ and C2H5SH+ via Collisional Activation. JOURNAL OF CHEMICAL PHYSICS 1997, 106, 8274-8277.
Yu-Ju Chen, C. L. Liao, and C. Y. Ng* A Molecular Beam Photoionization Mass Spectrometric Studies of Cr(CO)6, Mo(CO)6, and W(CO)6. JOURNAL OF CHEMICAL PHYSICS 1997, 107, 4527-4536.
C.-W. Hsu, K. T. Lu, M. Evans, Yu-Ju Chen, C. Y. Ng*, and P. Heimann A High Resolution Photoionization Study of Ne and Ar: Observation of Mass Analyzed Threshold Ions Using Synchrotron Radiation and Direct Current Electric Fields. JOURNAL OF CHEMICAL PHYSICS 1996, 105, 3950-3961.
Y.-S. Cheung, Yu-Ju Chen, C. Y. Ng*, See-Wing Chiu, and Wai- Kee Li Combining Theory with Experiment: Assessment of the Thermochemistry of SFn, SFn+, and SFn-. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 1995, 117,9725-9733.