中央研究院化學研究所－人員

我們實驗室的研究領域主要是有機合成及化學生物學為主，其研究方向是在活細胞中，利用特定化學標定方法結合產生螢光訊號化學探針，可以高選擇性螢光標定重要的生物分子，進而利用細胞影像技術追蹤分子位置，從中了解其生物分子的重要功能性。另一方面，在有機合成研究方向，我們著重新穎合成方法學的開發，並利用其方法應用於具有生物活性的醣共軛分子、抗病毒及細菌抑制小分子的合成。

~ 設計與合成抗病毒及細菌抑制分子
~ 設計與合成產生螢光訊號化學探針及化學感應器
~ 發展新穎化學方法在細胞中高選擇性修飾及螢光標定特定生物分子
~ 利用細胞影像技術探討特定生物分子於細胞的功能性

1. Huang, W.-F.; Weng, Y.-S.; Tseng, M.-C.; Shie, J.-J.* “Bioinspired Hg2+-sensing fluorogenic probe based on amino acid-functionalized rhodamine.” J. Photochem. Photobiol. A Chem. 2024, 456, 115806.
2. Chen, C.-Y.; Jian, C.-B.; Gao, H.-D.; Yu, X.-E.; Chang, Y.-C.; Leong, S. K.; Shie, J.-J.*; Lee, H.-M.* “Active loading liposomal cyanine 5.5 derivatives with deep self-quenching property and its applications in deep tissue imaging.” Sens. Diagn. 2024, 3, 1028–1038.
3. Leong, S. K.; Chen, Y.-J.; Hsiao, J.-C.; Tsai, C.-Y.; Shie, J.-J.* “Site-specific and multiple fluorogenic metabolic glycan labeling and glycoproteomic profiling in live cells.” ChemBioChem 2023, 24, e202300522.
4. Kolas, V.; Bandonil, J. S. A.; Wali, N.; Hsia, K.-C.; Shie, J.-J.*; Chung, B.-c.* “A synthetic pregnenolone analog promotes microtubule dynamics and neural development.” Cell Biosci. 2022, 12, 190.
5. Leong, S. K.; Hsiao, J.-C.; Shie, J.-J.* “A multiscale molecular dynamic analysis reveals the effect of sialylation on EGFR clustering in a CRISPR/Cas9-derived model.” Int. J. Mol. Sci. 2022, 23, 8754.
6. Shih, C.-T.; Kuo, B.-H.; Tsai, C.-Y.; Tseng, M.-C.; Shie, J.-J.* “Dibenzocyclooctendiones (DBCDOs): Arginine-selective chemical labeling reagents obtained through benzilic acid rearrangement.” Org. Lett. 2022, 24, 4694–4698.
7. Wu, C.-C.; Ambre, R.; Lee, M.-H.; Shie, J.-J.* “Flexible construction approach to the synthesis of 1,5-substituted pyrrole-3-carbaldehydes from 5-bromo-1,2,3-triazine.” Org. Lett. 2022, 24, 2889–2893.
8. Ponnapalli, K. K.; Ho, Y.-C.; Tseng, M.-C.; Vasamsett, B. V. S.; Shie, J.-J.* “One-pot glycosylation strategy assisted by ion mobility-mass spectrometry (IM–MS) analysis toward the synthesis of N-linked oligosaccharides.” J. Org. Chem. 2022, 87, 5339–5357.
9. Chou, P.-H.; Luo, C.-K.; Wali, N.; Lin, W.-Y.; Ng, S.-K.; Wang, C.-H.; Zhao, M.; Lin, S.-W.; Yang, P.-M.; Liu, P.-J.; Shie, J.-J.*; Wei, T.-T.* “A chemical probe inhibitor targeting STAT1 restricts cancer stem cell traits and angiogenesis in colorectal cancer.” J. Biomed. Sci. 2022, 29, 20.
10. Ou Yang, C.-H.; Liu, W.-H.; Yang, S.; Chiang, Y.-Y.; Shie, J.-J.* “Copper-mediated synthesis of (E)-β-aminoacrylonitriles from 1,2,3-triazine and secondary amines.” Eur. J. Org. Chem. 2022, e202200209.
11. Lin, L.-Z.; Yang, S.; Liu, W.-H.; Shie, J.-J.* “Dichotomous selectivity in indium-mediated aza-Barbier-type allylation of glycosyl sulfinylimines: Convenient access to the potent anti-influenza agents.” J. Org. Chem. 2022, 87, 2324–2335.
12. Shie, J.-J.; Fang, J.-M. “Development of effective anti-influenza drugs: congeners and conjugates – a review.” J. Biomed. Sci. 2019, 26, 84.
13. Lo, P.-W.; Shie, J.-J.; Chen, C.-H.; Wu, C.-Y.; Hsu, T.-L.; Wong, C.-H. “O-GlcNAcylation regulates the stability and enzymatic activity of the histone methyltransferase EZH2.” Proc. Natl. Acad. Sci. U. S. A. 2018, 115, 7302‒7307.
14. Shie, J.-J.*; Liu, Y.-C.; Hsiao, J.-C.; Fang, J.-M.; Wong, C.-H.* “A cell-permeable and triazole-forming fluorescence probe for glycoconjugate imaging in live cells.” Chem. Commun. 2017, 53, 1490‒1493.
15. Shie, J.-J.; Liu, Y.-C.; Lee, Y.-M.; Lim, C.; Fang, J.-M.; Wong, C.-H. “An azido-BODIPY probe for glycosylation: initiation of strong fluorescence upon triazole formation.” J. Am. Chem. Soc. 2014, 136, 9953‒9961.
16. Shie, J.-J.; Fang, J.-M. “Phosphonate congeners of oseltamivir and zanamivir as effective anti-influenza drugs: design, synthesis and biological activity.” J. Chin. Chem. Soc. 2014, 61, 127−141.
17. Shie, J.-J.; Fang, J.-M.; Lai, P.-T.; Wen, W.-H.; Wang, S.-Y.; Cheng, Y.-S. E.; Tsai, K.-C.; Yang, A.-S.; Wong, C.-H. “A practical synthesis of zanamivir phosphonate congeners with potent anti-influenza activity.” J. Am. Chem. Soc. 2011, 133, 17959–17965.
18. Shie, J.-J.; Chen, C.-A.; Lin, C.-C.; Ku, A. F.; Cheng, T.-J. R.; Fang, J.-M.; Wong, C.-H. “Regioselective synthesis of di-C-glycosylflavones possessing anti-inflammation activities.” Org. Biomol. Chem. 2010, 8, 4451–4462.
19. Shie, J.-J.; Fang, J.-M. “The development of anti-influenza drugs: Rational structural-design neuraminidase inhibitors.” Chemistry 2008, 66, 279–292. (in Chinese)
20. Kuo, C.-J.; Shie, J.-J.; Fang, J.-M.; Yen, G.-R.; Hsu, J. T.-A.; Liu, H.-G.; Tseng, S.-N.; Chang, S.-C.; Lee, C.-Y.; Shih, S.-R.; Liang, P.-H. “Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents.” Bioorg. Med. Chem. 2008, 16, 7388–7398.
21. Shie, J.-J.; Fang, J.-M.; Wong, C.-H. “A concise and flexible synthesis of the potent anti-influenza agents tamiflu and tamiphosphor.” Angew. Chem. Int. Ed. 2008, 47, 5788–5791.
22. Shie, J.-J.; Fang, J.-M.; Wang, S.-Y.; Tsai, K.-C.; Cheng, Y.-S. E.; Yang, A.-S.; Hsiao, S.-C.; Su, C.-Y.; Wong, C.-H. “Synthesis of tamiflu and its phosphonate congeners possessing potent anti-influenza activity.” J. Am. Chem. Soc. 2007, 129, 11892–11893.
23. Shie, J.-J.; Fang, J.-M. “Microwave-assisted one-pot tandem reactions for direct conversion of primary alcohols and aldehydes to triazines and tetrazoles in aqueous media.” J. Org. Chem. 2007, 72, 3141–3144.
24. Shie, J.-J.; Fang, J.-M.; Kuo, T.-H.; Kuo, C.-J.; Liang, P.-H.; Huang, H.-J.; Wu, Y.-T.; Jan, J.-T.; Cheng, Y.-S. E.; Wong, C.-H. “Inhibition of the severe acute respiratory syndrome 3CL protease by peptide- mimetic α,β-unsaturated esters.” Bioorg. Med. Chem. 2005, 13, 5240–5252.
25. Shie, J.-J.; Fang, J.-M.; Kuo, C.-J.; Kuo, T.-H.; Liang, P.-H.; Huang, H.-J.; Yang, W.-B.; Lin, C.-H.; Chen, J.-L.; Wu, Y.-T.; Wong, C.-H. “Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease.” J. Med. Chem. 2005, 48, 4469–4473.
26. Shie, J.-J.; Workman, P. S.; Evans, W. J.; Fang, J.-M. “Comparative study of TmI2, SmI2, and SmI2/HMPA in the cross-coupling reactions of 2-acetylthiophene and thiophene-2-carboxylate with carbonyl compounds.” Tetrahedron Lett. 2004, 45, 2703–2707.
27. Shie, J.-J.; Fang, J.-M. “Direct conversion of aldehydes to amides, tetrazoles, and triazines in aqueous media by one-pot tandem reactions.” J. Org. Chem. 2003, 68, 1158–1160.
28. Yang, S.-M.; Shie, J.-J.; Fang, J.-M.; Nandy, S. K.; Chang, H.-Y.; Lu, S.-H.; Wang, G. “Synthesis of polysubstituted benzothiophenes and sulfur containing polycyclic aromatic compounds via samarium diiodide promoted three-component coupling reactions of thiophene-2-carboxylate.” J. Org. Chem. 2002, 67, 5208–5215.
29. Shie, J.-J.; Yang, S.-M.; Chen, C.-T.; Fang, J.-M. “A novel photochromic system of 4,5-dialkenylthiophenes constructed by the samarium diiodide promoted coupling reactions of thiophene-2-carboxylate with aryl ketones.” Org. Lett. 2002, 4, 1099–1102.

Selected Patents:
1. Wong, C.-H.; Fang, J.-M.; Shie, J.-J. “Reactive labelling compounds and their uses thereof.” US Patent Application Publication (2015). Pub. No.: US 2015/0309041 A1.
2. Wong, C.-H.; Fang, J.-M.; Shie, J.-J. “Benzocyclooctyne compounds and their uses thereof.” US Patent Application Publication (2015). Pub. No.: US 2015/0241439 A1.
3. Wong, C.-H.; Fang, J.-M.; Cheng, Y.-S.; Shie, J.-J. “Zanamivir phosphonate congeners with anti-influenza activity and determining oseltamivir susceptibility of influenza viruses.” US Patent No. 9403855 (2016).
4. Wong, C.-H.; Fang, J.-M.; Shie, J.-J.; Cheng, Y.-S. E.; Jan, J.-T. “Synthesis of oseltamivir containing phosphonate congeners with anti-influenza activity.” US Patent No. US 7888337 (2011).

Update： 2024-07-09

1. Hao-Yu Chuang, Ruei-Yu He, Yung-An Huang, Wan-Ting Hsu, Ya-Jen Cheng, Zheng-Rong Guo, Niaz Wali, Ing-Shouh Hwang, Jiun-Jie Shie, Joseph Jen-Tse Huang* Engineered Droplet-Forming Peptide as Photocontrollable Phase Modulator for Fused in Sarcoma Protein. NATURE COMMUNICATIONS 2024-07-06, 15, 5686.
2. Mu-Rong Kao, Tzu-Hsuan Ma, Hsiang-Yu Chou, Shu-Chieh Chang, Lin-Chen Cheng, Kuo-Shiang Liao, Jiun-Jie Shie, Philip J. Harris, Chi-Huey Wong, Yves S. Y. Hsieh* A Robust α-L-Fucosidase from Prevotella nigrescens for Glycoengineering Therapeutic Antibodies. ACS CHEMICAL BIOLOGY 2024-06-24, 19, 1515-1524.
3. Shu-Chieh Chang, Rebecka Karmakar Saldivar, Mu-Rong Kao, Xiaohui Xing, Chun-Hong Yeh, Jiun-Jie Shie, D. Wade Abbott, Philip J. Harris, Yves S. Y. Hsieh* Two Glycosyl Transferase 2 Genes from the Gram-Positive Bacterium Clostridium ventriculi Encode (1,3;1,4)-β-D-Glucan Synthases. CARBOHYDRATE POLYMERS 2024-06-14, 342, 122394.
4. Wei-Fang Huang, Yu-Shan Weng, Mei-Chun Tseng, Jiun-Jie Shie* Bioinspired Hg2+-Sensing Fluorogenic Probe Based on Amino Acid–Functionalized Rhodamine. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY 2024-06-03, 456, 115806.
5. Chong-Yan Chen, Cheng-Bang Jian, Hua-De Gao, Xu-En Yu, Yuan-Chih Chang, Shwee Khuan Leong, Jiun-Jie Shie*, Hsien-Ming Lee* Active Loading Liposomal Cyanine 5.5 Derivatives with Deep Self-quenching Property and Its Applications in Deep Tissue Imaging. SENSORS & DIAGNOSTICS 2024-05-03, 3, 1028-1038.
6. Tzu-Yin Chen, Eileen Shyur, Tzu-Hsuan Ma, Lakshmi Wijeyewickrema, Sheng-Wei Lin, Mu-Rong Kao, Pi-Hui Liang, Jiun-Jie Shie, Er-Yuan Chuang, Jing-Ping Liou, and Yves S. Y. Hsieh* Effect of Sulfotyrosineand Negatively Charged Amino Acid of Leech-Derived Peptides on Binding and Inhibitory Activity Against Thrombin. CHEMBIOCHEM 2024-01, 25, e202300744.
7. Shwee Khuan Leong, Yi-Ju Chen, Jye-Chian Hsiao, Chun-Yi Tsai, Jiun-Jie Shie* Site-Specific and Multiple Fluorogenic Metabolic Glycan Labeling and Glycoproteomic Profiling in Live Cells. CHEMBIOCHEM 2023-07-25, 24, e202300522.
8. Ching-Han Lee, Yi-Yun Lee, Yu-Chu Chang, Wen-Li Pon, Sue-Ping Lee, Niaz Wali, Takehito Nakazawa, Yoichi Honda, Jiun-Jie Shie, Yen-Ping Hsueh* A Carnivorous Mushroom Paralyzes and Kills Nematodes via a Volatile Ketone. SCIENCE ADVANCES 2023-01-18, 9, eade4809.
9. Viktoryia Kolas, Jose Sandino A. Bandonil, Niaz Wali, Kuo‑Chiang Hsia, Jiun‑Jie Shie*, Bon‑chu Chung* A Synthetic Pregnenolone Analog Promotes Microtubule Dynamics and Neural Development. CELL AND BIOSCIENCE 2022-12-01, 12, 190.
10. Jing Li, Shih-Yi Hsiung, Mu-Rong Kao, Xiaohui Xing, Shu-Chieh Chang, Damao Wang, Pei-Yun Hsieh, Pi-Hui Liang, Zaibiao Zhu, Ting-Jen Rachel Cheng, Jiun-Jie Shie, Jing-Ping Liou, D. Wade Abbott, Sung Won Kwon, Yves S. Y. Hsieh* Structural Compositions and Biological Activities of Cell Wall Polysaccharides in the Rhizome, Stem, and Leaf of Polygonatum odoratum (Mill.) Druce. CARBOHYDRATE RESEARCH 2022-09-01, 521, 108662.
11. Shwee Khuan Leong, Jye-Chian Hsiao, Jiun-Jie Shie* A Multiscale Molecular Dynamic Analysis Reveals the Effect of Sialylation on EGFR Clustering in a CRISPR/Cas9-Derived Model. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022-08-06, 23, 8754.
12. Cheng-Ting Shih, Bo-Hong Kuo, Chun-Yi Tsai, Mei-Chun Tseng, Jiun-Jie Shie* Dibenzocyclooctendiones (DBCDOs): Arginine-Selective Chemical Labeling Reagents Obtained through Benzilic Acid Rearrangement. ORGANIC LETTERS 2022-06-21, 24, 4694-4698.
13. Tzu-Tang Wei, Mark Chandy, Masataka Nishiga, Angela Zhang, Kaavya Krishna Kumar, Dilip Thomas, Amit Manhas, Siyeon Rhee, Johanne Marie Justesen, Ian Y. Chen, Hung-Ta Wo, Saereh Khanamiri, Johnson Y. Yang, Frederick J. Seidl, Noah Z. Burns, Chun Liu, Nazish Sayed, Jiun-Jie Shie, Chih-Fan Yeh, Kai-Chien Yang, Edward Lau, Kara L. Lynch, Manuel Rivas, Brian K. Kobilka, Joseph C. Wu* Cannabinoid Receptor 1 Antagonist Genistein Attenuates Marijuana-induced Vascular Inflammation. CELL 2022-05-12, 185, 1676-1693.
14. Chien-Chi Wu, Ram Ambre, Meng-Hsuan Lee, Jiun-Jie Shie* Flexible Construction Approach to the Synthesis of 1,5-Substituted Pyrrole-3-carbaldehydes from 5-Bromo-1,2,3-triazine. ORGANIC LETTERS 2022-04-06, 24, 2889-2893.
15. Kalyana Kumar Ponnapalli, Yi-Chi Ho, Mei-Chun Tseng, Bhanu Vijaya Sekhar Vasamsetti, Jiun-Jie Shie* One-Pot Glycosylation Strategy Assisted by Ion Mobility–Mass Spectrometry Analysis toward the Synthesis of N-Linked Oligosaccharides. JOURNAL OF ORGANIC CHEMISTRY 2022-04-04, 87, 5339-5357.
16. Pei-Hsuan Chou, Cong-Kai Luo, Niaz Wali, Wen-Yen Lin, Shang-Kok Ng, Chun-Hao Wang, Mingtao Zhao, Sheng-Wei Lin, Pei-Ming Yang, Pin-Jung Liu, Jiun-Jie Shie*, Tzu-Tang Wei* A Chemical Probe Inhibitor Targeting STAT1 Restricts Cancer Stem Cell Traits and Angiogenesis in Colorectal Cancer. JOURNAL OF BIOMEDICAL SCIENCE 2022-03-22, 29, 20.
17. Cheng-Hsin Ou Yang, Wan-Hsuan Liu, Sheng Yang, Yao-Yu Chiang, Jiun-Jie Shie* Copper-Mediated Synthesis of (E)-β-Aminoacrylonitriles from 1,2,3-Triazine and Secondary Amines. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2022-02-28, (12), e202200209.
18. Long-Zhi Lin, Sheng Yang, Wan-Hsuan Liu, Jiun-Jie Shie* Dichotomous Selectivity in Indium-Mediated Aza-Barbier-Type Allylation of 2-N-Acetyl Glycosyl Sulfinylimines in Brine: Convenient Access to Potent Anti-Influenza Agents. JOURNAL OF ORGANIC CHEMISTRY 2022-01-25, 87, 2324-2335.
19. Devi Wahyuningtyas, Wen-Hao Chen, Ruei-Yu He, Yung-An Huang, Chia-Kang Tsao, Yu-Jung He, Chu-Yi Yu, Po-Chao Lu, Yu-Cai Chen, Sheng-Hann Wang, Ka Chon Ng, Bryan Po-Wen Chen, Pei-Kuen Wei, Jiun-Jie Shie, Chun-Hong Kuo, Y. Henry Sun, and Joseph Jen-Tse Huang* Polyglutamine-Specific Gold Nanoparticle Complex Alleviates Mutant Huntingtin-Induced Toxicity. ACS APPLIED MATERIALS & INTERFACES 2021-12-16, 13, 60894-60906.
20. Danni Wu, Kathleen Joyce Carillo, Jiun-Jie Shie, Steve S.-F. Yu, Der-Lii M. Tzou* Resolving Entangled JH-H-Coupling Patterns for Steroidal Structure Determinations by NMR Spectroscopy. MOLECULES 2021-04-30, 26, 2643.
21. Tsung‐Shing Andrew Wang*, Ruo‐Yu Wu, Yu Hong, Zhe‐Chong Wang, Tsung‐Lin Li, Jiun‐Jie Shie, Cheng‐Chih Hsu Labeling and Characterization of Phenol‐Containing Glycopeptides Using Chemoselective Probes with Isotope Tags. ChemBioChem 2021-04-29, 22, 2415-2419.
22. Jing Li, Damao Wang, Shu-Chieh Chang, Pi-Hui Liang, Vaibhav Srivastava, Shih-Yun Guu, Jiun-Jie Shie, Kay-Hooi Khoo, Vincent Bulone, Yves S. Y. Hsieh* Production of Structurally Defined Chito-Oligosaccharides with a Single N-Acetylation at Their Reducing End Using a Newly Discovered Chitinase from Paenibacillus pabuli. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2021-03-10, 69, 3371-3379.
23. Jia-Tsrong Jan, Ting-Jen Rachel Cheng, Yu-Pu Juang, Hsiu-Hua Ma, Ying-Ta Wu, Wen-Bin Yang, Cheng-Wei Cheng, Xiaorui Chen, Ting-Hung Chou, Jiun-Jie Shie, Wei-Chieh Cheng, Rong-Jie Chein, Shi-Shan Mao, Pi-Hui Liang*, Che Ma*, Shang-Cheng Hung*, Chi-Huey Wong* Identification of Existing Pharmaceuticals and Herbal Medicines as Inhibitors of SARS-CoV-2 Infection. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2021-02-02, 118(5), e2021579118.
24. Yu-Pu Juang, You-Yu Lin, She-Hung Chan, Chun-Kai Chang , Jiun-Jie Shie, Yves SY Hsieh, Jih-Hwa Guh, Pi-Hui Liang* Synthesis, Distribution Analysis and Mechanism Studies of N-Acyl Glucosamine-Bearing Oleanolic Saponins. BIOORGANIC CHEMISTRY 2020-04, 99, 103835.
25. Ching-Han Lee, Han-Wen Chang, Ching-Ting Yang, Niaz Wali, Jiun-Jie Shie, Yen-Ping Hsueh* Sensory Cilia as the Achilles Heel of Nematodes When Attacked by Carnivorous Mushrooms. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2020-03, 117, 6014-6022.
26. Kathleen Joyce D. Carillo, Danni Wu, Su-Ching Lin, Shen-Long Tsai, Jiun-Jie Shie, Der-Lii M. Tzou* 1H/13C Chemical Shifts and Cation Binding Dataset of the Corticosteroid Prednisolone Titrated with Metal Cations. DATA IN BRIEF 2019-12, 27, 104620.
27. Jiun-Jie Shie, Jim-Min Fang* Development of Effective Anti-Influenza Drugs: Congeners and Conjugates – A Review. JOURNAL OF BIOMEDICAL SCIENCE 2019-10, 26, 84.
28. Kathleen D. Carillo, Danni Wu, Su-Ching Lin, Shen-Long Tsai, Jiun-Jie Shie, Der-Lii M.Tzou* Magnesium and Calcium Reveal Different Chelating Effects in a Steroid Compound: A Model Study of Prednisolone Using NMR Spectroscopy. STEROIDS 2019-10, 150, 108429.
29. Danni Wu, Kathleen Joyce D. Carillo, Shen‐Long Tsai, Jiun‐Jie Shie, Der‐Lii M. Tzou* Solid‐State Nuclear Magnetic Resonance Investigation of Neurosteroid Compounds and Magnesium Interactions. JOURNAL OF THE CHINESE CHEMICAL SOCIETY 2019-03, 66, 1318-1326.
30. Pei-Wen Lo, Jiun-Jie Shie, Chein-Hung Chen, Chung-Yi Wu, Tsui-Ling Hsu, Chi-Huey Wong* O-GlcNAcylation Regulates the Stability and Enzymatic Activity of the Histone Methyltransferase EZH2. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2018-07, 115, 7302-7307.
31. Yu-Hin Ho, Sheng-Yang Ho, Cheng-Chih Hsu, Jiun-Jie Shie, Tsung-Shing Andrew Wang* Utilizing An Iron(iii)-Chelation Masking Strategy to Prepare Mono- and Bis-functionalized Aerobactin Analogues for Targeting Pathogenic Bacteria. CHEMICAL COMMUNICATIONS 2017-08, 53, 9265-9268.
32. Vathan Kumar, Jin Soo Shin, Jiun-Jie Shie, Keun Bon Ku, Chonsaeng Kim, Yun Young Go, Kai-Fa Huang, Meehyein Kim*, Po-Huang Liang* Identification and Evaluation of Potent Middle East Respiratory Syndrome Coronavirus (MERS-CoV) 3CLPro Inhibitors. Antiviral Research 2017-03, 141, 101-106.
33. Jiun-Jie Shie*, Ying-Chih Liu, Jye-Chian Hsiao, Jim-Min Fang, Chi-Huey Wong* A Cell-Permeable and Triazole-Forming Fluorescent Probe for Glycoconjugate Imaging in Live Cells . CHEMICAL COMMUNICATIONS 2017-01, 53, 1490-1493.
34. Jiun-Jie Shie, Ying-Chih Liu, Yu-Ming Lee, Carmay Lim, Jim-Min Fang, Chi-Huey Wong* An Azido-BODIPY Probe for Glycosylation: Initiation of Strong Fluorescence upon Triazole Formation. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2014-07, 136, 9953-9961.
35. Chun-Lin Chen, Tzu-Chen Lin, Shi-Yun Wang, Jiun-Jie Shie, Keng-Chang Tsai, Yih-Shyun E. Cheng, Jia-Tsrong Jan, Chun-Jung Lin*, Jim-Min Fang*, Chi-Huey Wong* Tamiphosphor Monoesters as Effective Anti-influenza Agents. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2014-06, 81, 106-118.
36. Chung-Kai Cheng, Chen-Hsuan Tsai, Jiun-Jie Shie, Jim-Min Fang* From Neuraminidase Inhibitors to Conjugates: A Step towards Better Anti-Influenza Drugs. Future Medicinal Chemistry 2014-05, 6, 757-774.
37. Yuan-Siao Chen, Hui-Ming Yu, Jiun-Jie Shie, Ting-Jen Rachel Cheng, Chung-Yi Wu*, Jim-Min Fang*, Chi-Huey Wong* Chemical Constituents of Plectranthus Amboinicus and the Synthetic Analogs Possessing Anti-Inflammatory Activity. BIOORGANIC & MEDICINAL CHEMISTRY 2014-03, 22, 1766-1772.
38. Jiun-Jie Shie, Jim-Min Fang* Phosphonate Congeners of Oseltamivir and Zanamivir as Effective Anti-influenza Drugs: Design, Synthesis and Biological Activity. JOURNAL OF THE CHINESE CHEMICAL SOCIETY 2014-01, 61, 127-141.
39. Ting-Jen R. Cheng, Steven Weinheimer, E. Bart Tarbet, Jia-Tsrong Jan, Yih-Shyun E. Cheng, Jiun-Jie Shie, Chun-Lin Chen, Chih-An Chen, Wei-Che Hsieh, Pei-Wei Huang, Wei-Hao Lin, Shi-Yun Wang, Jim-Min Fang*, Oliver Yoa-Pu Hu*, Chi-Huey Wong* Development of Oseltamivir Phosphonate Congeners as Anti-Influenza Agents. JOURNAL OF MEDICINAL CHEMISTRY 2012-10, 55, 8657-8670.
40. Jiun-Jie Shie, Jim-Min Fang*, Po-Ting Lai, Wen-Hsien Wen, Shi-Yun Wang, Yih-Shyun E. Cheng, Keng-Chang Tsai, An-Suei Yang, Chi-Huey Wong* A Practical Synthesis of Zanamivir Phosphonate Congeners with Potent Anti-Influenza Activity. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2011-11, 133, 17959-17965.
41. Jiun-Jie Shie, Chih-An Chen, Chih-Chien Lin, Angela Fay Ku, Cheng, T.-J. R.; Ting-Jen R. Cheng, Jim-Min Fang*, Chi-Huey Wong* Regioselective Synthesis of Di-C-Glycosylflavones Possessing Anti-Inflammation Activities. ORGANIC & BIOMOLECULAR CHEMISTRY 2010-10, 8, 4451-4462.
42. Chia-Ching Cho, Jia-Nan Liu, Chung-Hsun Chien, Jiun-Jie Shie, Ting-Chu Chen, Jim-Min Fang* Direct Amidation of Aldoses and Decarboxylative Amidation of α-Keto Acids: An Efficient Conjugation Method for Carbohydrate Molecules. JOURNAL OF ORGANIC CHEMISTRY 2009-02, 74, 1549-1556.
43. Ching-Yao Su, Shi-Yun Wang, Jiun-Jie Shie, King-Song Jeng, Nigel J. Temperton, Jim-Min Fang, Chi-Huey Wong, Yih-Shyun E. Cheng* In Vitro Evaluation of Neuraminidase Inhibitors Using the Neuraminidase-Dependent Release Assay of Hemagglutinin-Pseudotyped Viruses. ANTIVIRAL RESEARCH 2008-09, 79, 199-205.
44. Chih-Jung Kuo, Jiun-Jie Shie, Jim-Min Fang*, Guei-Rung Yen, John T.-A. Hsu, Hun-Ge Liu, Sung-Nain Tseng, Shih-Cheng Chang, Ching-Yin Lee, Shin-Ru Shih, Po-Huang Liang* Design, Synthesis, and Evaluation of 3C Protease Inhibitors as Anti-Enterovirus 71 Agents. BIOORGANIC & MEDICINAL CHEMISTRY 2008-08, 16, 7388-7398.
45. Jiun-Jie Shie, Jim-Min Fang*, Chi-Huey Wong A Concise and Flexible Synthesis of the Potent Anti-Influenza Agents Tamiflu and Tamiphosphor. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2008-06, 47, 5788-5791.
46. Jin-Ching Lee, Shin-Ru Shih, Ten-Yuan Chang, Huan-Yi Tseng, Ya-Feng Shih, Kuei-Jung Yen, Wei-Chun Chen, Jiun-Jie Shie, Jim-Min Fang, Po-Huang Liang, Yu-Sheng Chao, John T.-A. Hsu* A Mammalian Cell-Based Reverse Two-Hybrid System for Functional Analysis of 3C Viral Protease of Human Enterovirus 71. ANALYTICAL BIOCHEMISTRY 2008-04, 375, 115-123.
47. 謝俊結, 方俊民* 流感藥物的設計與發展. 化學 2008, 第六十六卷第四期, 頁279-292.
48. Cheng-Chung Lee, Chih-Jung Kuo, Min-Feng Hsu, Po-Huang Liang, Jim-Min Fang, Jiun-Jie Shie, Andrew H.-J. Wang* Structural Basis of Mercury- and Zinc-Conjugated Complexes as SARS-CoV 3C-Like Protease Inhibitors. FEBS LETTERS 2007-11, 581, 5454-5458.
49. Jiun-Jie Shie, Jim-Min Fang*, Shi-Yun Wang, Keng-Chang Tsai, Yih-Shyun E. Cheng, An-Suei Yang, Shih-Chia Hsiao, Ching-Yao Su, Chi-Huey Wong Synthesis of Tamiflu and Its Phosphonate Congeners Possessing Potent Anti-Influenza Activity. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2007-10, 129, 11892-11893.
50. Jiun-Jie Shie, Jim-Min Fang* Microwave-Assisted One-Pot Tandem Reactions for Direct Conversion of Primary Alcohols and Aldehydes to Triazines and Tetrazoles in Aqueous Media. JOURNAL OF ORGANIC CHEMISTRY 2007-04, 72, 3141-3144.
51. Chung-Yi Wu, Ke-Yung King, Chih-Jung Kuo, Jim-Min Fang, Ying-Ta Wu, Ming-Yi Ho, Chung-Lin Liao, Jiun-Jie Shie, Po-Huang Liang, Chi-Huey Wong* Stable Benzotriazole Esters Mechanism-Based Inactivators of the Severe Acute Respiratory Syndrome 3CL Protease. CHEMISTRY & BIOLOGY 2006-03, 13, 261-268.
52. Jiun-Jie Shie, Jim-Min Fang*, Tun-Hsun Kuo, Chih-Jung Kuo, Po-Huang Liang*, Hung-Jyun Huang, Ying-Ta Wu, Jia-Tsrong Jan, Yih-Shyun E. Cheng, Chi-Huey Wong Inhibition of the Severe Acute Respiratory Syndrome 3CL Protease by Peptidomimetic α,β-Unsaturated Esters. BIOORGANIC & MEDICINAL CHEMISTRY 2005-09, 13, 5240-5252.
53. Jiun-Jie Shie, Jim-Min Fang*, Chih-Jung Kuo, Tun-Hsun Kuo, Po-Huang Liang*, Hung-Jyun Huang, Wen-Bin Yang, Chun-Hung Lin, Jiun-Ling Chen, Yin-Ta Wu, Chi-Huey Wong Discovery of Potent Anilide Inhibitors Against the Severe Acute Respiratory Syndrome 3CL Protease. JOURNAL OF MEDICINAL CHEMISTRY 2005-06, 48, 4469-4473.
54. Jiun-Jie Shie, Penny S Workman, William J Evans, Jim-Min Fang* Comparative Study of TmI2, SmI2, and SmI2/HMPA in the Cross-Coupling Reactions of 2-Acetylthiophene and Thiophene-2-carboxylate with Carbonyl Compounds. TETRAHEDRON LETTERS 2004-03, 45, 2703-2707.
55. Ming‐Yi Chen, Jue‐Liang Hsu, Jiun‐Jie Shie, Jim‐Min Fang* Direct Oxidative Amidation of Aldoses by Iodine in Ammonia Water. JOURNAL OF THE CHINESE CHEMICAL SOCIETY 2003-02, 50, 129-133.
56. Jiun-Jie Shie, Jim-Min Fang* Direct Conversion of Aldehydes to Amides, Tetrazoles, and Triazines in Aqueous Media by One-Pot Tandem Reactions . JOURNAL OF ORGANIC CHEMISTRY 2003-02, 68,1158-1160.
57. Shyh-Ming Yang, Jiun-Jie Shie, Jim-Min Fang*, Sandip Kumar Nandy, Hung-Yu Chang, Syn-Hung Lu, Gladys Wang Synthesis of Polysubstituted Benzothiophenes and Sulfur-Containing Polycyclic Aromatic Compounds via Samarium Diiodide Promoted Three-Component Coupling Reactions of Thiophene-2-carboxylate. JOURNAL OF ORGANIC CHEMISTRY 2002-07, 67, 5208-5215.
58. Jiun-Jie Shie, Shyh-Ming Yang, Chao-Tsen Chen, Jim-Min Fang* A Novel Photochromic System of 4,5-Dialkenylthiophenes Constructed by the Samarium Diiodide Promoted Coupling Reactions of Thiophene-2-carboxylate with Aryl Ketones. ORGANIC LETTERS 2002-04, 4, 1099-1102.
59. Adam Shih-Yuan Lee*, Hsiu-Chih Yeh, Jiun-Jie Shie A Novel, Highly Efficient and Selective Desilylating Method for Trialkylsilyl Ethers. TETRAHEDRON LETTERS 1998-07, 39, 5249-5252.

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