Development of new synthetic strategies and methods
Asymmetric Catalysis - interdisciplinary research that combines organic, inorganic, organometallic, and biomimetic chemistry
Total synthesis of natural products and designed molecules
Drug Discovery - Type 2 Diabetes, Neurodegenerative Disease

• "Thieme Chemistry Journals Award 2020"  (2020)
• "2017 Asian Core Program Lectureship Award, Singapore"  (2017-12)
• "2016 Asian Core Program Lectureship Award, Malaysia"  (2016-12)
• "2016 Outstanding Young Scholar, Shui-Mu Foundation of Chemistry"  (2016)
• "2015 Asian Core Program Lectureship Award, Hong Kong"  (2015-12)
• "2015 Asian Core Program Lectureship Award, Japan"  (2015-12)
• "2014 Asian Core Program Lectureship Award of Korea"  (2014-12)
• "2014 Asian Core Program Lectureship Award of China"  (2014-12)

1. King, K.; Lin, N.-P.; Cheng, Y.-H.; Chen, G.-H.; Chein, R.-J. Isolation of a Positive Modulator of GLP-1 Signaling from the Seed of Trigonella foenum-graecum (Fenugreek). J. Biol. Chem. 2015, 290, 26235.
2. Wang, S.-H.; Chein, R.-J. (Thiolan-2-yl)diphenylmethyl Benzyl Ether/N,N'-diarylurea Cocatalyzed Asymmetric Aziridination of Cinnamyl Bromide and Aryl Aldimine. Tetrahedron (Symposium-in-Print, Invited Article), 2015, DOI:10.1016/j.tet.2014.12.063.
3. Wang, D.; Chen, M.; Chein, R.-J.; Ching, W.-M.; Hung, C.-H.; Tzou, D.-L. M. Cations Specifically Induce a Conformational Change in trans-Dehydroandrosterone: A Solid-State NMR Study. Steroids, 2015, 96, 73.
4. Lo, H.-J.; Lin, C.-Y.; Tseng, M.-C.; Chein, R.-J. Lithiation of a Silyl Ether; Formation on an ortho-Fries Hydroxyketone. Angew. Chem. Int. Ed. 2014, 53, 9026.
5. Lin, C.-Y.; Chein, R.-J. Lithiation of a Silyl Ether: Anionic Si→C Alkyl Migration. SYNLETT 2014, 25, 2827.
6. Kumar, C. N. S. S. P.; Chein, R.-J. Synthesis of Labdane Diterpenes Galanal A and B from (+)-Sclareolide Org. Lett. 2014, 16, 2990.
7. Siddappa, R. K. G.; Chang, C.-W.; Chein, R.-J. From Precursor to Catalyst: The Involvement of [Ru(ƞ5-Cp*)Cl₂>]₂ in Highly Branch Selective Allylic Etherfication of Cinnamyl Chloride Tetrahedron Lett. 2014, 55, 1031.
8. Huang, M.-T.; Wu, H.-Y.; Chein, R.-J. Enantioselective Synthesis of Diaryl Aziridines Using Tetrahydrothiophene-Based Chiral Sulfides as Organocatalysts Chem. Commun. 2014, 50, 1101.
9. Wu, H.-Y.; Chang, C.-W.; Chein, R.-J. Enantioselective Synthesis of (Thiolan-2-yl)diphenylmethanol and Its Application in Asymmetric, Catalytic Sulfur Ylide-Mediated Epoxidation J. Org. Chem. 2013, 78, 5788.
10. Chang, C.-W.; Chein, R.-J. Absolute Configuration of Anti-HIV-1 Agent (−)-Concentricolide: Total Synthesis of (+)-(R)-Concentricolide. J. Org. Chem. 2011, 76, 4154.
11. Chein, R.-J.; Corey, E. J. Strong Conformational Preferences of Heteroaromatic Ethers and Electron Pair Repulsion. Organic Letters 2010, 12, 132.
12. Chein, R.-J.; Yeung, Y.-Y.; Corey, E. J. Highly Enantioselective Oxazaborolidine-Catalyzed Reduction of 1,3-Dicarbonyl Compounds: Role of the Additive Diethylaniline. Organic Letters 2009, 11, 1611.
13. Kurti, L.; Chein, R.-J.; Corey, E. J. Conformational Energetics of Cationic Backbone Rearrangements in Triterpenoid Biosynthesis Provide an Insight into Enzymatic Control of Product. J. Am. Chem. Soc. 2008, 130, 9031.
14. Yeung, Y.-Y.; Chein, R.-J.; Corey, E. J. Conversion of Torgov’s Synthesis of Estrone into a Highly Enantioselective and Efficient Process. J. Am. Chem. Soc. 2007, 129, 10346.
15. Ho, T.-L.; Chein, R.-J. Ritter Reaction of 1-Aryl-1-fluoro-2-haloethanes. J. Chin. Chem. Soc. 2006, 53, 429.
16. Ho, T.-L.; Chein, R.-J. Total Synthesis of (+)-β-Himachalene. Helv. Chim. Act. 2006, 89, 231.
17. Ho, T.-L.; Chein, R.-J. Unusual Thionation via Fragmentation. J. Chin. Chem. Soc. 2005, 52, 1223.
18. Ho, T.-L.; Chein, R.-J. Intervention of Phenonium Ion in Ritter Reactions. J. Org. Chem. 2004, 69, 591.
19. Ho, T.-L.; Kung, L.-R.; Chein, R.-J. Total Synthesis of (±)-2-Isocyanoallopupukeanane. J. Org. Chem. 2000, 65, 5774.
20. Ho, T.-L.; Chein, R.-J. A Synthesis of 6-Myoporol. J. Nat. Prod. 1997, 60, 493.
21. Ho, T.-L.; Chein, R.-J. Synthesis of (-)-Furodysinin from (+)-Limonene. Chem. Commun. 1996, 1147.

Update： 2016-01-06

1. Rou-Jie Huang, Tiow-Gan Ong, Rong-Jie Chein* Total synthesis of cassane-type diterpenoid pikrosalvin. JOURNAL OF THE CHINESE CHEMICAL SOCIETY 2023-11-14, DOI: 10.1002/jccs.202300384, 1-9.
2. Kuei-Wei Chiu, Rong-Jie Chein* Exploring the Power of Sulfur, Silicon, and Organocatalysis: Innovative Strategies for Asymmetric Synthesis and Advanced Synthetic Methodology. SYNLETT 2023-05-24, DOI: 10.1055/a-2099-6478, 1-7.
3. Kuei-Wei Chiu, Yu-Hsun Tseng, Ying-Xin Li, Rong-Jie Chein* Biomimetic Total Synthesis of Clavicipitic Acid: A DDQ-Mediated Intramolecular Cross-Dehydrogenative Coupling Approach. ORGANIC LETTERS 2023-05-06, https://doi.org/10.1021/acs.orglett.3c01029, 1-5.
4. Chia-Yi Lin, Kuo-Yen Huang, Shih-Han Kao, Ming-Shiu Lin, Chih-Chien Lin, Shuenn-Chen Yang, Wei-Chia Chung, Ya-Hsuan Chang, Rong-Jie Chein, Pan-Chyr Yang* Small-molecule PIK-93 modulates the tumor microenvironment to improve immune checkpoint blockade response. SCIENCE ADVANCES 2023-04-07, 9, eade994-9.
5. Tzu-Ho Chen, Chien-Ting Chen, Chi-Fang Lee, Rou-Chein Chen, Kuan-Lin Chen, Yuan-Chun Lu, Suh-Yuen Liang, Mai-Truc Pham, Yerra Koteswara Rao, Shih-Hsiung Wu, Rong-Jie Chein, Hsiao-Ching Lin* The Biosynthetic Gene Cluster of Mushroom-Derived Antrocin Encodes Two Dual Functional Haloacid Dehalogenase-Like Terpene Cyclases. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2022-12-30, https://doi.org/10.1002/anie.202215566, 1-9.
6. Yu-Chen Guo, Kuei-Wei Chiu, Rong-Jie Chein* (Thiolan-2-yl)diphenylmethanol Benzyl Ether-Catalyzed Asymmetric Cyclopropanation of Chalcones. JOURNAL OF ORGANIC CHEMISTRY 2022-12-21, https://doi.org/10.1021/acs.joc.2c02573, 1-4.
7. Soumendranath Mukhopadhyay, Ramalingam Boobalan, Rong-Jie Chein* Oxathiaborolium-Catalyzed Enantioselective [2+2] Cycloadditions. ORGANIC & BIOMOLECULAR CHEMISTRY 2022-10-18, DOI: 10.1039/d2ob01779b, 1-5.
8. Suhas Ravindra Bavikar, Hong-Jay Lo, Chebolu Naga Sesha Sai Pavan Kumar, Rong-Jie Chein* Total Synthesis of (–)-Panduratin D. CHEMICAL COMMUNICATIONS 2022-07-05, 58, 8564-8567.
9. Ding-Nan Shih, Ramalingam Boobalan, Yi-Hung Liu, Rong-Jie Chein*, Ching-Wen Chiu* [B−Cl−B]+ Cations: Chloroborane Masked Chiral Borenium Ions. INORGANIC CHEMISTRY 2021-10-21, 60, 16266-16272.
10. Pei-Tung Cheng, Yu-Hsun Tseng, Rong-Jie Chein* Organoselenium-Catalyzed Asymmetric Cyclopropanations of (E)-Chalcones. ORGANIC LETTERS 2021-10-06, 23(20), 8104-8108.
11. Ramalingam Boobalan, Rong-Jie Chein* Oxathiaborolium-Catalyzed Enantioselective [4 + 2] Cycloaddition and Its Application in Lewis Acid Coordinated and Chiral Lewis Acid Catalyzed [4 + 2] Cycloaddition. ORGANIC LETTERS 2021-08, 23(17), 6760-6764.
12. Ching-Pei Hsu, Yi-Hung Liu, Ramalingam Boobalan, Ya-Fan Lin, Rong-Jie Chein*, Ching-Wen Chiu* Chiral Tetra-coordinate Aluminum Cation in Catalysis. Organometallics 2021-04-22, 40(9), 1244-1251.
13. Ranuka T. Hewage, Rou-Jie Huang, Shu-Jung Lai, Ya-Chu Lien, Shao-Hsing Weng, Dehai Li, Yu-Ju Chen, Shih-Hsiung Wu, Rong-Jie Chein*, Hsiao-Ching Lin* An Enzyme-Mediated Aza-Michael Addition Is Involved in the Biosynthesis of an Imidazoyl Hybrid Product of Conidiogenone B. ORGANIC LETTERS 2021-02-11, 23(5), 1904-1909.
14. Jia-Tsrong Jan, Ting-Jen Rachel Cheng, Yu-Pu Juang, Hsiu-Hua Ma, Ying-Ta Wu, Wen-Bin Yang, Cheng-Wei Cheng, Xiaorui Chen, Ting-Hung Chou, Jiun-Jie Shie, Wei-Chieh Cheng, Rong-Jie Chein, Shi-Shan Mao, Pi-Hui Liang*, Che Ma*, Shang-Cheng Hung*, Chi-Huey Wong* Identification of Existing Pharmaceuticals and Herbal Medicines as Inhibitors of SARS-CoV-2 Infection. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2021-02-02, 118(5), e2021579118.
15. Nai-Pin Lina, Rong-Jie Chein* Total synthesis and absolute structure of N55, a positive modulator of GLP-1 signaling. ORGANIC & BIOMOLECULAR CHEMISTRY 2020-10-21, 18, 8899-8907.
16. 陳榮傑 瑞德西韋藥物相關緣由以及化學有機合成資訊. 化學 2020-06-01, 78(20, 163-166.
17. Yu-Rong Chen, Annavareddi Naresh, Suh-Yuen Liang, Chun-Hung Lin, Rong-Jie Chein* and Hsiao-Ching Lin* Discovery of a Dual Function Cytochrome P450 that Catalyzes Enyne Formation in Cyclohexanoid Terpenoid Biosynthesis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2020-04-28, 59, 13537-13541.
18. Kuan-Lin Chen, Chen-Yu Lai, Mai-Truc Pham, Rong-Jie Chein, Yi Tang, and Hsiao-Ching Lin* Enzyme-Catalyzed Azepinoindole Formation in Clavine Alkaloid Biosynthesis. ORGANIC LETTERS 2020-04-03, 22(8), 3302-3306.
19. Chia-Yi Lin, Hsin-Yi Wu, Yuan-Ling Hsu, Ting-Jen Rachel Cheng, Jyung-Hurng Liu, Rou-Jie Huang, Tzu Hung Hsiao, Chia-Jen Wang, Pei-Fang Hung, Albert Lan, Szu-Hua Pan*, Rong-Jie Chein*, Chi-Huey Wong, Pan-Chyr Yang Suppression of Drug-Resistant Non-Small-Cell Lung Cancer with Inhibitors Targeting Minichromosomal Maintenance Protein. JOURNAL OF MEDICINAL CHEMISTRY 2020-03-03, 63(6), 3172-3187.
20. Ting-Hung Chou, Bo-Hung Yu, Rong-Jie Chein* ZnI2/Zn(OTf)2–TsOH: A Versatile Combined-Acid System for Catalytic Intramolecular Hydrofunctionalization and Polyene Cyclization. Chemical Communications 2019-11-21, 55, 13522.
21. Ming-Shiu Lin, Tse-Ming Hong, Ting-Hung Chou, Shuenn-Chen Yang, Wei-Chia Chung, Chia-Wei Weng, Mei-Ling Tsai, Ting-Jen Rachel Cheng, Jeremy J. W. Chen, Te-Chang Lee, Chi-Huey Wong, Rong-Jie Chein*, Pan-Chyr Yang* 4(1H)-quinolone derivatives overcome acquired resistance to anti-microtubule agents by targeting the colchicine site of β-tubulin. European Journal of Medicinal Chemistry 2019-11-01, 181, 111584.
22. Singam Naveen Kumar, Suhas Ravindra Bavikar, Chebolu Naga Sesha Sai Pavan Kumar, Isaac Furay Yu, Rong-Jie Chein* From Carbamate to Chalcone: Consecutive Anionic Fries Rearrangement, Anionic Si → C Alkyl Rearrangement, and Claisen–Schmidt Condensation. Organic Letters 2018-08-27, 20(17), 5362-5366.
23. Hao-Wei Cheng, Rong-Jie Chein, Ting-Jen Cheng, Pei-Shan Wu, Hsin-Yi Wu, Pei-Fang Hung, Chia-Jen Wang, Yuan-Ling Hsu, Jau-Min Wong, Ang Yuan, Chi-Huey Wong, Pan-Chyr Yang, Szu-Hua Pan* The 2-anilino-4-amino-5-aroylthiazole-type compound AS7128 inhibits lung cancer growth through decreased iASPP and p53 interaction. CANCER SCIENCE 2017-12-25, .
24. Singam Naveen Kumar, Isaac Furay Yu, Rong-Jie Chein* Oxathiaborolium: a Type of Chiral Lewis Acid Catalyst and Its Application in Catalytic and Highly Enantioselective Diels−Alder Reactions. ORGANIC LETTERS 2017-01, 19, 22-25.
25. Shih-Che Lin, Rong-Jie Chein* Total Synthesis of the Labdane Diterpenes Galanal A and Galanal B from Geraniol. JOURNAL OF ORGANIC CHEMISTRY 2016-1, 82, 1575-1583.
26. Shang-Hua Wang, and Rong-Jie Chein* (Thiolan-2-yl)diphenylmethyl Benzyl Ether/N,N'-diarylurea Cocatalyzed Asymmetric Aziridination of Cinnamyl Bromide and Aryl Aldimine. TETRAHEDRON 2016-03, 72, 2607-2615.
27. Chia-I Yen, Szu-Mam Liu, Wei-Shang Lo, Jhe-Wei Wu, Yi-Hsin Liu, Rong-Jie Chein, Renqiang Yang, Kevin C.-W. Wu, Jih Ru Hwu, Nianhan Ma,* Fa-Kuen Shieh* Cytotoxicityof Postmodified Zeolitic-Imidazolate Framework-90 (ZIF-90) Nanocrystals: Correlation between Functionality and Toxicity. CHEMISTRY-A EUROPEAN JOURNAL 2016-01, 22, 2925-2929.
28. Klim King*, Nai-Pin Lin, Yu-Hong Cheng, Gao-Hui Chen, Rong-Jie Chein* Isolation of Positive Modulator of Glucagon-like Peptide-1 Signaling from Trigonella foenum-graecum (Fenugreek) Seed. JOURNAL OF BIOLOGICAL CHEMISTRY 2015-09, doi:10.1074/jbc.M115.684274.
29. Darong Wang, Meiman Chen, Rong-Jie Chein, Wei-Min Ching, Chen-Hsiung Hung, Der-Lii M. Tzou* Cation ion specifically induces a conformational change in trans-dehydroandrosterone – A solid-state NMR study. STEROIDS 2015-04, 96, 73-80.
30. Chin-Yin Lin, Rong-Jie Chein* Lithiation of a Silyl Ether: Anionic Si→C Alkyl Migration. SYNLETT 2014-12, 25, 2827–2830.
31. Chebolu Naga Sesha Sai Pavan Kumar, Rong-Jie Chein* Synthesis of Labdane Diterpenes Galanal A and B from (+)–Sclareolide. ORGANIC LETTERS 2014-06, 16, 2990−2992.
32. Ravi Kumara Guralamatta Siddappa, Chih-Wei Chang, Rong-Jie Chein From Precursor to Catalyst: The Involvement of [Ru(ƞ5-Cp*)Cl2]2 in Highly Branch Selective Allylic Etherfication of Cinnamyl Chloride. TETRAHEDRON LETTERS 2014-01, 55, 1031-1035.
33. Meng-Ting Huang, Hsin-Yi Wu, Rong-Jie Chein* Enantioselective Synthesis of Diaryl Aziridines Using Tetrahydrothiophene-Based Chiral Sulfides as Organocatalysts. CHEMICAL COMMUNICATIONS 2014-01, 50, 1101-1103.
34. Hong-Jay Lo, Chin-Yin Lin, Mei-Chun Tseng, and Rong-Jie Chein* Lithiation of a Silyl Ether; Formation on an ortho-Fries Hydroxyketone. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2014, 53, 9026 –9029.
35. Hsin-Yi Wu, Chih-Wei Chang, Rong-Jie Chein* Enantioselective Synthesis of (Thiolan-2-yl)diphenylmethanol and Its Application in Asymmetric, Catalytic Sulfur Ylide-Mediated Epoxidation. JOURNAL OF ORGANIC CHEMISTRY 2013-05, 78, 5788-5793.
36. Chih-Wei Chang, Rong-Jie Chein* The Absolute Configuration of Anti-HIV-1 Agent (-)-Concentricolide : Total Synthesis of (+)-(R)-Concentricolide. JOURNAL OF ORGANIC CHEMISTRY 2011-04, 76(10), 4154-4157.
37. Rong-Jie Chein, E. J. Corey* Strong Conformational Preferences of Heteroaromatic Ethers and Electron Pair Repulsion. ORGANIC LETTERS 2010-01, 12(1), 132-135.

• 良薑化合物及其類似物之合成 SYNTHESIS OF GALANAL COMPOUNDS AND ANALOGUES THEREOF
  Taiwan: I516474 2016
• 良薑化合物及其類似物之合成 SYNTHESIS OF GALANAL COMPOUNDS AND ANALOGUES THEREOF
  USA-regular: US 9193665 B2 2015