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Mei-Chun Tseng (曾美郡)

Mass Anlysis

Mei-Chun Tseng (曾美郡)

    886-2-55728534
    886-2-55728682
    mei-chunchem.sinica.edu.tw
researcherid:C-8743-2015
ORCID id:0000-0002-7970-5278
Senior Research Specialist (2016-present)；Adjunct Associate Professor, Soochow University (2020-present) ；Secretary General, Taiwan Society for Mass Spectrometry (2021-present); Associate Research Specialist (2011-2016)；Assistant Research Specialist (2005-2010); Adjunct Assistant Professor, Soochow University (2007-2020) B. S.,Tamkang University (1999) ； Ph.D., National Taiwan University (2004)；Postdoctoral Research Associate, Academia Sinica (2004-2005)； Mass Spectrometry Technician Award, Taiwan Society for Mass Spectrometry (2012)；Excellent Service Performance, Academia Sinica, (2015, 2016, 2017)；
Research Interests

Study the electrospray ionization mechanism to improve the detection limit and contaminant tolerance of electrospray mass spectrometry.
Development of a new liquid chromatography/mass spectrometry and capillary electrophoresis/mass spectrometry interface with a higher sensitivity and capability for a variety of operation modes.
Trace chemical analysis of environmental pollutants.
Analysis of drug doping in Chinese medicine.
Analysis of polymer and additives.
Analysis of inorganic molecules (macrocyclic compounds and metal chelates) and organic molecules.



Awards & Honors
  • 中研院貴重儀器使用效益評估特優  (2017)
  • 中研院貴重儀器使用效益評估特優  (2016)
  • 中研院貴重儀器使用效益評估特優  (2015)
  • 2012年優秀質譜技術從業人員獎  (2012)
Selected Publications
Journal Paper
  1. Chan, Y, C,; Bai, Y.; Chen, W. C.; Chen, H. Y.; Li, C. Y.; Wu, Y. Y.; Tseng, M. C.; Yap, G. P. A.; Zhao, L.; Chen, H. Y.; Ong, T. G. Synergistic Catalysis via Bronsted Acid Modulated Frustrated Lewis Pair-Like Reaction in Carbodicarbene. Angew. Chem. Int. Ed., 2021.
  2. Lee, C. H.; Huang, H. C.; Tseng, M. C.; Chen, C. J. An Extractive Nanoelectrospray Ionization-Mass Spectrometry Method for Chinese Herbal Medicine Authentication. J. Food Drug Anal. 2021.
  3. Mernie, E. G.; Tolesa, L. D.; Lee, M. J.; Tseng, M. C.; Chen, Y. J. Direct Oligosaccharide Profiling using Thin-Layer Chromatography Coupled with Ionic Liquid-Stabilized Nanomatrix-Assisted Laser Desorption Ionization Mass Spectrometry. Anal. Chem. 2019, 91, 11544.
  4. Yu, H. T.; Chen, B. Y.; Li, B. Y.; Tseng, M. C.; Han, C. C.; Shyu, S. G. Efficient Pretreatment of Lignocellulosic Biomass with High Recovery of Solid Lignin and Fermentable Sugars using Fenton Reaction. Biotechnol Biofuels. 2018, 11, 287.
  5. Chatterjee, B.; Lin, M. H.; Chen, C. C.; Peng, K. L.; Wu, M. S.; Tseng, M. C.; Chen, Y. J.; Shen, J. C. K. Active DNA Demethylation by DNMT3A and DNMT3B in Vitro and of Methylated Episomal DNA in Transiently Transfected Cells. BBA. Gene. Regul. Mech. 2018, 1861, 1048.
  6. Yen, T. H.; He, Z. C.; Lee, G. H.; Tseng, M. C.; Shen, Y. H.; Tseng, T. W.; Liaw, W. F.; Chiang, M. H. Reduced Thione Ligation is Preferred Over Neutral Phosphine Ligation in Diiron Biomimics Regarding Electronic Functionality: A Spectroscopic and Computational Investigation. Chem. Commun., 2017, 53, 332. (Advance Article)
  7. Primadona, I.; Lai, Y. H.; Capangpangan, R. Y.; Obena, R. P.; Tseng, M. C.; Huang, M. F.; Chang, H. T.; Li, S. T.; Wu, C. Y.; Chien, W. T.; Lin, C. C.; Wang, Y. S.; Chen, Y. J. Functionalized HgTe nanoparticles promote laserinduced solid phase ionization/dissociation for comprehensive glycan sequencing. Analyst 2016, 141, 6093.
  8. Liu, Y. C.; Chu, K. T.; Huang, Y. L.; Hsu, C. H.; Lee, G. H.; Tseng, M. C.; Chiang, M. H. Protonation/Reduction of Carbonyl-Rich Diiron Complexes and the Direct Observation of Triprotonated Species: New Insights into the Electrocatalytic Mechanism of Hydrogen Formation. ACS Catal. 2016, 6, 2559.
  9. Chen, C. W.; Tsao, N.; Huang, L. Y.; Yen, Y.; Liu, X.; Wang Y H.; Tseng, M. C.; Chen, Y. J.; Ho, Y. C.; Chen, C. F.; Tien, S. C.; Chang, Z. F. The impact of dUTPase on ribonucleotide reductase-induced genome instability in cancer cells. Cell Reports 2016, 16, 1287.
  10. Liao, H. Y.; Tsai, F. J.; Lai, C. C.;Tseng, M. C.; Chen, Y. J. A Rapid Approach for Fabricating Hydrophobic Plate and Hydrophilic Plate or Sample Purification and Mass Spectrometry Analysis. Analyst 2016, 141, 2183.
  11. Obena, R. P.; Tseng, M. C.; Primadona, I.; Hsiao, J.; Li, I C.; Capangpangan, R. Y.; Lu, H. F.; Li, W. S.; Chao, I.; Lin, C. C.; Chen, Y. J. UV-activated multilayer nanomatrix provides onestep tunable carbohydrate structural characterization in MALDI-MS. Chem. Sci. 2015, 6, 4790. (Equal contribution as first author)
  12. Chu, K. T.; Liu, Y.C.; Huang, Y. L.; Lee, G. H.; Tseng, M. C.; Chiang, M. H. Redox Communication within Multinuclear Iron–Sulfur Complexes Related to Electronic Interplay in the Active Site of [FeFe] Hydrogenase. Chem. Eur. J. 2015, 21, 6852.
  13. Chen, H. J.; Tseng, M. C.; Hsu, I. J.; Chen, W. T.; Han, C. C.; Shyu, S. G. Ligand free copper(I)-catalyzed synthesis of diaryl ether with Cs2CO3 via a free radical path, Dalton Trans. 2015, 44, 12086
  14. Tseng, C. K.; Lee, C. R.; Tseng,  M. C.; Han, C. C.; Shyu, S. G.  Reactivity of [K3(phen)8][Cu(NPh2)2]3 a Possible Intermediate in the Copper(i)-catalyzed N-arylation of N-phenylaniline.  Dalton Trans. 2014, 43, 7020 (Cover story)
  15. Chen, H. J.; Hsu, I. J.; Tseng, M. C.; Shyu, S. G. Possible intermediates of Cu(phen)-catalyzed C–O cross-coupling of phenol with an aryl bromide by in situ ESI-MS and EPR studies  Dalton Trans., 2014, 43, 11410.
  16. Lo, H. J.; Lin, C. Y.; Tseng, M. C.; Chein, R. J. Lithiation of a Silyl Ether: Formation of an ortho-Fries Hydroxyketone.  Angew. Chem. Int. Ed., 2014, 53, 9026.
  17. Hossain, Md. M.; Tseng, M. C.; Lee, C. R.; Shyu, S. G. Synthesis, Structure, and Reactivity of [Cu(phen) 2]ClO2 Aerobic Oxidation of Cl- to ClO2- at Room Temperature. Eur. J. Inorg. Chem., 2014, 1, 36
  18. Chen, C. J.; Lai, C. C.; Tseng, M. C.; Liu, Y. C.; Liu, Y. H.; Chiou, L. W.; Tsai, F. J. A Novel Titanium Dioxide-Polydimethylsiloxane Plate for Phosphopeptide Enrichment and Mass Spectrometry Analysis. Anal. Chim. Acta 2014, 812, 105.
  19. Chen, C. J.; Lai, C. C.; Tseng, M. C.; Liu, Y. C.; Tsai, F. J. Simple Fabrication of Hydrophobic Surface Target for Increased Sensitivity and Homogeneity in MALDI-TOF Analysis of Peptides, Phosphopeptides, Carbohydrates and Proteins. Anal. Chim. Acta 2013, 789, 31.
  20. Hu, C. M.; Yeh, M. T.; Chen, C. W.; Tsao, N.; Gao, Q. Z.; Chang, C. Y.; Lee, M. H.; Fang, J. M.; Sheu, S. Y.; Lin, C. J.; Tseng, M. C.; Chen, Y. J.; Chang, Z. F. Tumor Cells Require Thymidylate Kinase to Prevent dUTP Incorporation During DNA Repair. Cancer Cell 2012, 22, 36.
  21. Chen, C. J.; Chen, W. Y.; Tseng, M. C.; Chen, Y. R. Tunnel Frit: A Non-Metallic In-Capillary Frit for nano-UHPLC-MS Applications, Anal. Chem. 2012, 84, 297.
  22. Ho, Y. C.; Tseng, M. C.; Lu, Y. W.; Lin, C. C.; Chen, Y. J.; Fuh, M. R. Nanoparticle-assisted MALDI-TOF MS combined with Seed-Layer Surface Preparation for Quantification of Small Molecules. Anal. Chim. Acta 2011, 697, 1. (Cover Story)
  23. Cheng, S. W.; Tseng, M. C.; Lii, K. H.; Lee, C. R.; Shyu, S. G. Intermediates of Copper(I)-Catalyzed C–S Cross Coupling of Thiophenol with Aryl Halide by in Situ ESI-MS Study. Chem. Commun. 2011, 47, 5599.
  24. Tseng, C. K ; Tseng, M. C.; Han, C. C.; Shyu, S. G. A Copper (II) Complex as an Intermediate of Copper(I)-Catalyzed C-N Cross Coupling of N-Phenylaniline with Aryl Halide by in situ ESI-MS Study. Chem. Commun. 2011, 47, 6686.
  25. Ho, Y. C.; Tseng, M. C.; Lu, Y. W.; Lin, C. C.; Chen, Y. J.; Fuh, M. R. Nanoparticle-assisted MALDI-TOF MS Combined with Seed-Layer Surface Preparation for Quantification of Small Molecules, Anal. Chim. Acta 2011, 697, 1. (Cover Story)
  26. Chen, C. J.; Tseng, M. C.; Lin, H. J.; Lin, T. W.; Chen, Y. R. A Rapid Visual Indicator for Surfactant Abundance (VISA) in MS-Based Membrane and General Proteomics Applications. Anal. Chem. 2010, 82, 8283.
  27. Hsueh, Y. H.; Huang, J. L.; Tseng, M. C.; Her, G. R. Sensitivity Improvement of CE/ESI/MS Analysis of Gangliosides Using a Liquid-Junction/low-flow Interface. Electrophoresis 2010, 31, 1138.
  28. Tseng, M. C.; Obena, R.; Lu, Y. W.; Lin, P. C.; Lin, P. Y.; Yen, Y. S.; Lin, J. T.; Huang, L. D.; Lu, K. L.; Lai, L. L.; Lin, C. C.; Chen, Y. J. Dihydrobenzoic Acid Modified Nanoparticle as a MALDI MS Matrix for Soft Ionization and Structure Determination of Small Molecules with Diverse Structures. Journal of the American Society Mass Spectrometry 2010, 21, 1930. (Cover Story)
  29. Chen, C. Y.; Lin, T. P.; Chen, C. K.; Lin, S. C.; Tseng, M. C.; Wen,Y. S.; Sun, S. S. New Chromogenic and Fluorescent Probes for Anion Detection: Formation of a [2+2] Supramolecular Complex on Addition of Fluoride With Positive Homotropic Cooperativity. J. Org. Chem. 2008, 73, 900.
  30. Lin, P. C.; Tseng, M. C.; Su, A. K.; Chen, Y. J.; Lin, C. C. Functionalized Magnetic Nanoparticles for Small Molecule Isolation, Identification and Quantification. Anal. Chem. 2007, 79, 3401.
  31. Lin, P. C.; Ueng, S. H.; Tseng, M. C.; Ko, J. L.; Huang, K. T.; Yu, S. C.; Adak, A, K.; Chen, Y. J.; Lin, C. C. Site-specific protein modification through Cu-I-catalyzed 1,2,3-triazole formation and its implementation in protein microarray fabrication. Angew. Chem., Int. Ed. 2006, 45, 4286.
  32. Chen, Y. R.; Tseng, M. C.; Her, G. R. Design and Performance of a Low Flow CE/ESI-MS Interface Using an Emitter with Dual Beveled Edge. Electrophoresis 2005, 26, 1376.
  33. Tseng, M. C.; Chen, Y. R.; Her, G. R. A Low-Makeup Beveled Tip CE/EDI MS Interface for MEKC and Nonvolatile Buffer CE. Anal. Chem. 2004, 76, 6306.
  34. Tseng, M. C.; Chen, Y. R.; Her, G. R. A Beveled Tip Sheath Liquid Interface for CE/ESI MS. Electrophoresis 2004, 25, 2084.
  35. Chen, Y. R.; Tseng, M. C.; Chang, Y. Z.; Her, G. R. A Low-Flow CE/ESI-MS Interface for Capillary Zone Electrophoresis, Large Volume Sample Stacking and Micellar Electrokinetic Chromatography. Anal. Chem. 2003, 75, 503.
  36. Cheng, H. L.; Tseng, M. C.; Tsai, P. L.; Her, G. R. Analysis of Synthetic Chemical Drugs in Adulterated Chinese Medicine by Capillary Electrophoresis/Electrospray Mass Spectrometry. Rapid Commun. Mass Spectrometry 2001, 15, 1473.
Paper for Conference:
  1. Direct Oligosaccharide Profiling using Thin-Layer Chromatography Coupled with Ionic Liquid-Stabilized Nanomatrix-Assisted Laser Desorption-Ionization Mass Spectrometry; E. G. Mernie, L. D. Tolesa, M. J. Lee, M. C. Tseng,* Y. J. Chen*. 18th Human Proteome Organization World Congress. 2019, AU. 
  2. Thin-layer Chromatography Coupled with Nano-matrix Bsed MALDI-TOF Mass Spectrometry for Structural Elucidation of Carbohydrates; E. Gizaw, M. C. Tseng*; Y. J. Chen*. 22th International Mass Spectrometry Conference. 2018, IT.

Update： 2021-07-22

Journal Paper
  1. Tzu-Ho Chen, Kevin Garnir, Chong-Yan Chen, Cheng-Bang Jian, Hua-De Gao, Bill Cheng, Mei-Chun Tseng, Cécile Moucheron, Andrée Kirsch-De Mesmaeker*, Hsien-Ming Lee* A Toolkit for Engineering Proteins in Living Cells: Peptide with a Tryptophan-Selective Ru-TAP Complex to Regioselectively Photolabel Specific Proteins. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2022-09-22, 144(39), 18117-18125.
  2. Cheng-Ting Shih, Bo-Hong Kuo, Chun-Yi Tsai, Mei-Chun Tseng, Jiun-Jie Shie* Dibenzocyclooctendiones (DBCDOs): Arginine-Selective Chemical Labeling Reagents Obtained through Benzilic Acid Rearrangement. ORGANIC LETTERS 2022-06-21, 24(25), 4694-4698.
  3. Kalyana Kumar Ponnapalli, Yi-Chi Ho, Mei-Chun Tseng, Bhanu Vijaya Sekhar Vasamsetti, Jiun-Jie Shie* One-Pot Glycosylation Strategy Assisted by Ion Mobility-Mass Spectrometry Analysis toward the Synthesis of N-linked Oligosaccharides. JOURNAL OF ORGANIC CHEMISTRY 2022-04-04, 87(8), 5339-5357.
  4. Pin-An Hsieh, Peng-Jen Chen, Lian-Ming Lyu, Sheng-Yu Chen, Mei-Chun Tseng, Mei-Ying Chung, Wei-Hung Chiang, Jeng-Lung Chen, and Chun-Hong Kuo Enhanced Production of Formic Acid in Electrochemical CO2 Reduction over Pd-Doped BiOCl Nanosheets. ACS Applied Materials & Interfaces 2021-12-03, 13(49), 58799-58808.
  5. Chia-Hsin Lee, Hui-Chi Huang, Mei-Chun Tseng, Chao-Jung Chen* An Extractive Nanoelectrospray Ionization-Mass Spectrometry Method for Chinese Herbal Medicine Authentication. JOURNAL OF FOOD AND DRUG ANALYSIS 2021-09-15, 9(3), 468-489.
  6. Yi-Chen Chan, Yuna Bai, Wen-Ching Chen, Hsing-Yin Chen, Chen-Yu Li, Ying-Yann Wu, Mei-Chun Tseng, Glenn P. A. Yap, Lili Zhao*, Hsuan-Ying Chen*, Tiow-Gan Ong*, Synergistic Catalysis via Brønsted Acid Modulated Frustrated Lewis Pair‐Like Reaction in Carbodicarbene. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2021-09-01, 60(36), 19949-19956.
  7. Elias Gizaw Mernie, Mei-Chun Tseng, Wen-Ti Wu, Tzu-Ming Liu, Yu-Ju Chen* Nanoprobe-Based Mass Spectrometry and Fourier Transform Infrared Spectroscopy for Rapid Phospholipid Profiling. JOURNAL OF THE CHINESE CHEMICAL SOCIETY 2021-08-23, 1, 1-13.
  8. Yi-Chih Chiu, Mei-Chun Tseng, Chun-Hua Hsu* Expanding the Substrate Specificity of Macro Domains toward 3〃-Isomer of O-Acetyl –ADP-Ribose. ACS CATALYSIS 2021-08-21, 11, 11075-11090.
  9. E. G. Mernie, L. D. Tolesa, M. J. Lee, M. C. Tseng*, Y. J. Chen* Direct Oligosaccharide Profiling using Thin-Layer Chromatography Coupled with Ionic Liquid-Stabilized Nanomatrix-Assisted Laser Desorption Ionization Mass Spectrometry. ANALYTICAL CHEMISTRY 2019-08-20, 91, 11544-11552.
  10. C. C. Hsieh, Y. C. Liu, M. C. Tseng, M. H. Chiang, Y. C. Horng* Dioxygen Activation by a Dinuclear Thiolate-ligated Fe(II) Complex. DALTON TRANSACTIONS 2019, 48, 379-386.
  11. 2. Biswanat Chatterjee, Miao-Hsia Lin, Chun-Chang Chen, Kai-Lin Peng, Mu-Sheng Wu, Mei-Chun Tseng, Yu-Ju Chen, Che-Kun James Shen* Active DNA Demethylation by DNMT3A and DNMT3B In Vitro and of Methylated Episomal DNA in Transiently Transfected Cells. BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 2018-11, 1861, 1048-1061.
  12. Hui-Tse Yu, Bo-Yu Chen, Bing-Yi Li, Mei-Chun Tseng, Chien-Chung Han and Shin-Guang Shyu Efficient Pretreatment of Lignocellulosic Biomass with High Recovery of Solid Lignin and Fementable Sugars using Fenton Reactrion. Biotechnol Biofuels 2018-10-20, 11, 287-298.
  13. 3. Kai-Chi Chang, Chan-Yu Chen, Tzu-Pin Lin, Po-Jen Ku, Chun-Lin Chen, Chih-Ming Wang, Hsiu-Mei Lin, Mei-Chun Tseng, Ashutosh S. Singha, Shih-Sheng Sun Platinum(II)-directed Self-assembly Loop Complexes for Anion Recognition and Sensing. J. Chin. Chem. Soc. 2018-02, 65, 141-148.
  14. Tao-Hung Yen, Zong-Cheng He, Gene-Hsiang Lee, Mei-Chun Tseng, Yu-Hsuan Shen, Tien-Wen Tseng*, Wen-Feng Liaw*, Ming-Hsi Chiang* Reduced thione ligation is preferred over neutral phosphine ligation in diiron biomimics regarding electronic functionality: a spectroscopic and computational investigation. Chemical Communications 2017, 53(2), 332-335.
  15. Indah Primadona, Yin-Hung Lai, Rey Y. Capangpangan, Rofeamor P. Obena, Mei-Chun Tseng, Ming-Feng Huang, Huan-Tsung Chang, Shiou-Ting Li, Chung-Yi Wu, Wei-Ting Chien, Chun-Cheng Lin, Yi-Sheng Wang*, Yu-Ju Chen* Functionalized HgTe Nanoparticles Promote Laser-Induced Solid Phase Ionization/Dissociation for Comprehensive Glycan Sequencing. ANALYST 2016-08, 141, 6093-6103.
  16. Chih-Wei Chen, Ning Tsao, Lin-Yi Huang, Yun Yen, Xiyong Liu, Christine Lehman, Yuh-Hwa Wang, Mei-Chun Tseng, Yu-Ju Chen, Yi-Chi Ho, Chian-Feng Chen, Zee-Fen Chang The Impact of dUTPase on Ribonucleotide Reductase-Induced Genome Instability in Cancer Cells. Cell Report 2016-08, 16, 1287–1299.
  17. Yu-Chiao Liu, Kai-Ti Chu, Yi-Lan Huang, Cheng-Huey Lee, Mei-Chun Tseng, Ming-Hsi ChiangHsu, Gene-Hsiang  Protonation/Reduction of Carbonyl-Rich Diiron Complexes and the Direct Observation of Triprotonated Species: Insights into the Electrocatalytic Mechanism of Hydrogen Formation. ACS Catalysis 2016-03, 6(4), 2559–2576.
  18. Hsin-Yi Liao, Fuu-Jen Tsai, Chien-Chen Lai, Mei-Chun Tseng, Chung Y. Hsue, Chao-Jung Chen Rapid Fabrication of Functionalized Plates for Peptides, Glycopeptides and Protein Purification and Mass Spectrometry Analysis. ANALYST 2016-02, 141, 2183-2190.
  19. Chih-Wen Yang, Shih-Cheng Hsu, Mei-Ying Chung, Mei-Chun Tseng, Te-Wei Chiu, Chun-Hong Kuo* Serial Morphological Transformations of Au Nanocrystals via Post-Synthetic Galvanic Dissolution and Recursive Growth. The Journal of Physical Chemistry C 2015-12, 119, 29006-29014.
  20. Rofeamor P. Obena, Mei-Chun Tseng, Indah Primadona, Jun Hsiao, I-Che Li, Rey Y. Capangpangan, Hsiu-Fong Lu, Wan-Sheung Li, Ito Chao, Chun-Cheng Lin, Yu-Ju Chen* UV-Activated Multilayer Nanomatrix Provides One-Step Tunable Carbohydrate Structural Characterization in MALDI-MS. Chemical Science 2015-05, 6, 4790-4800.
  21. Hong-Jie Chen, Mei-Chun Tseng, I-Jui Hsu, Wei-Ting Chen, Chien-Chung Han*, Shin-Guang Shyu*  Ligand Free Copper(I)-Catalyzed Synthesis of Diaryl Ether with Cs2CO3 via a Free Radical Path. DALTON TRANSACTIONS 2015-03, 44, 12086-12090.
  22. Kai-Ti Chu, Yu-Chiao Liu, Yi-Lan Huang, Gene-Hsiang Lee, Mei-Chun Tseng, Ming-Hsi Chiang* Redox Communication within Multinuclear Iron–Sulfur Complexes Related to Electronic Interplay in the Active Site of [FeFe] Hydrogenase. Chemistry - A European Journal 2015-03, 21, 6852-6861.
  23. Hong-Jay Lo, Chin-Yin Lin, Mei-Chun Tseng, Rong-Jie Chein* Lithiation of a Silyl Ether: Formation of an ortho-Fries Hydroxyketone . ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2014-06, 53, 9026-9029.
  24. Hong-Jie Chen, I-Jui Hsu, Mei-Chun Tseng, Shin-Guang Shyu* Possible Intermediates of Cu(phen)-Catalyzed C–O Cross-Coupling of Phenol with an Aryl Bromide by in situ ESI-MS and EPR Studies. DALTON TRANSACTIONS 2014-05, 46, 11410-11417.
  25. Chia-Kai Tseng, Chi-Rung Lee, Mei-Chun Tseng, Chien-Chung Han*, Shin-Guang Shyu* Reactivity of [K3(phen)8][Cu(NPh2)2]3—a Possible Intermediate in the Copper(I)-Catalyzed N-Arylation of N-Phenylaniline. DALTON TRANSACTIONS 2014-05, 43(19), 7020–7027.
  26. Chao-Jung Chen∗, Chien-Chen Lai, Mei-Chun Tseng, Yu-Ching Liu, Yu-Huei Liu, Liang-Wei Chiou, Fuu-Jen Tsai A Novel Titanium Dioxide-Polydimethylsiloxane Plate for Phosphopeptide Enrichment and Mass Spectrometry Analysis. ANALYTICA CHIMICA ACTA 2014-02, 812, 105– 113.
  27. Md. Munkir Hossain, Mei-Chun Tseng, Chi-Rung Lee, Shin-Guang Shyu* Synthesis, Structure, and Reactivity of [Cu(phen)2]ClO2: Aerobic Oxidation of Cl– to ClO2 – at Room Temperature. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY 2014-01, 2014(1), 36-40.
  28. Chao-Jung Chen, Chien-Chen Lai, Mei-Chun Tseng, Yu-Ching Liu, Shih-Yi Lin, Fuu-Jen Tsai* Simple Fabrication of Hydrophobic Surface Target for Increased Sensitivity and Homogeneity in MALDI-TOF Analysis of Peptides, Phosphopeptides, Carbohydrates and Proteins. ANALYTICA CHIMICA ACTA 2013-06, 783(14), 31-38.
  29. Chun-Mei Hu, Ming-Tyng Yeh, Ning Tsao, Chih-Wei Chen, Quan-Ze Gao, Chia-Yun Chang, Ming-Hsiang Lee, Jim-Min Fang, Sheh-Yi Sheu, Chow-Jaw Lin, Mei-Chun Tseng, Yu-Ju Chen, Zee-Fen Chang* Tumor Cells Require Thymidylate Kinase to Prevent dUTP Incorporation During DNA Repair. CANCER CELL 2012-07, 22, 1.
  30. Chao-Jung Chen, Wei-Yun Chen, Mei-chun Tseng, Yet-Ran Chen* Tunnel Frit: A Non-Metallic In-Capillary Frit for Nano-UHPLC-MS Applications. ANALYTICAL CHEMISTRY 2012-01, 84, 297-303.
  31. Chia-Kai Tseng, Mei-Chun Tseng, Chien-Chung Han, Shin-Guang Shyu* A Copper (II) Complex as An Intermediate of Copper(I)-Catalyzed C-N Cross Coupling of N-Phenylaniline with Aryl Halide by in Situ ESI-MS Study. CHEMICAL COMMUNICATIONS 2011-04, 47, 6686-6688.
  32. Yi-Chi Ho, Mei-Chun Tseng, Ying-Wei Lu, Chun-Cheng Lin, Yu-Ju Chen, Ming-Ren Fuh∗ Nanoparticle-Assisted MALDI-TOF MS Combined with Seed-Layer Surface Preparation for Quantification of Small Molecules. ANALYTICA CHIMICA ACTA 2011-04, 697, 1-7.
  33. Shao-Wen Cheng, Mei-Chun Tseng, Kwang-Hwa Lii, Chi-Rung Lee, Shin-Guang Shyu* Intermediates of Copper(I)-Catalyzed C–S Cross Coupling of Thiophenol with Aryl Halide by in Situ ESI-MS Study. CHEMICAL COMMUNICATIONS 2011-03, 47, 5599-5601.
  34. Mei-Chun Tseng, Rofeamor Obena, Ying-Wei Lu, Po-Chiao Lin, Ping-Yu Lin, Yung-Sheng Yen, Jiann-Tsuen Lin, Li-De Huang, Kuang-Lieh Lu, Long-Li Lai, Chun-Cheng Lin, Yu-Ju Chen* Dihydrobenzoic Acid Modified Nanoparticle as A MALDI-TOF MS Matrix for Soft Ionization and Structure Determination of Small Molecules with Diverse Structures. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY 2010-11, 21, 1930-1939.
  35. Chao-Jung Chen, Mei-Chun Tseng, Han-Jia Lin, Ting-Wei Lin, Yet-Ran Chen* Visual Indicator for Surfactant Abundance in MS-Based Membrane and General Proteomics Applications. ANALYTICAL CHEMISTRY 2010-10, 82,8283-8290.
  36. Yun-Hung Hsueh, Ju-Li Huang, Mei-Chun Tseng, Guor-Rong Her* Sensitivity Improvement of CE/ESI/MS Analysis of Gangliosides Using A Liquid-Junction/Low-Flow Interface. ELECTROPHORESIS 2010-09, 31, 1138-1143.
  37. Chan-Yu Chen, Tzu-Pin Lin, Chine-Kun Chen, Su-Ching Lin, Mei-Chun Tseng, Yuh-Sheng Wen, Shih-Sheng Sun* “New Chromogenic and Fluorescent Probes for Anion Detection: Formation of A [2+2] Supramolecular Complex on Addition of Fluoride with Positive Homotropic Cooperativity” . JOURNAL OF ORGANIC CHEMISTRY 2008, 73, 900.
  38. Po-Chiao Lin, Mei-Chun Tseng, An-Kai Su, Yu-Ju Chen, Chung-Cheng Lin*  “Functionalized Magnetic Nanoparticles for Small Molecule Isolation, Identification and Quantification” . Analytical Chemistry 2007, 79, 3401.
  39. Po-Chiao Lin, Shau-Hua Ueng, Mei-Chun Tseng, Jia-Ling Ko, Kuo-Ting Huang, Sheng-Chieh Yu, Avijit Kumar Adak, Yu-Ju Chen, Chun-Cheng Lin* “Site-Specific Protein Modification through Cu-Catalyzed 1,2,3-Triazole Formation and Its Implementation in Protein Microarray Fabrication” . ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2006, 45, 4286.
  40. Yet-Ran Chen, Mei-Chun Tseng, Guor-Rong Her* “Design and Performance of a Low Flow CE/ESI-MS Interface Using an Emitter with Dual Beveled Edge” . Electrophoresis 2005, 26, 1376.
  41. Mei-Chun Tseng, Yet-Ran Chen, Guor-Rong Her*  "A Beveled Tip Sheath Liquid Interface for CE/ESI MS". Electrophoresis 2004, 25, 2084.
  42. Mei-Chun Tseng, Yet-Ran Chen, Guor-Rong Her* “A Low-Makeup Beveled Tip CE/ESI MS Interface for MEKC and Nonvolatile Buffer CE” . ANALYTICAL CHEMISTRY 2004, 76, 6306.
  43. Yet-Ran Chen, Mei-Chun Tseng, Yan-Zin Chang, Guor-Rong Her* A Low-Flow CE/ESI-MS Interface for Capillary Zone Electrophoresis, Large Volume Sample Stacking and Micellar Electrokinetic Chromatography". ANALYTICAL CHEMISTRY 2003, 75, 503-507.
  44. Shih-Tsung Hsiao, Mei-Chun Tseng, Yet-Ran Chen, Guor-Rong Her* Analysis of Polymer Additives by Matrix-Assisted Laser Desorption Ionization / Time of Flight Mass Spectrometer Using Delayed Extraction and Collision Induced Dissociation" . Journal of the Chinese Chemical Society 2001, 48, 1017.
  45. Hsing-Ling Cheng, Mei-Chun Tseng, Pei-Lun Tsai, Guor-Rong Her* “Analysis of Synthetic Chemical Drugs in Adulterated Chinese Medicine by Capillary Electrophoresis/Electrospray Mass Spectrometry”. Rapid Communications in Mass Spectrometry 2001, 15, 1473.
Book/Papers
  1. 何國榮、陳玉如、廖寶琦、王亦生、陳逸然、「曾美郡」、黃友利、賴建成、彭文平、何彥鵬、許邦弘、李福安、陳朝榮、林俊利、陳頌方、李茂榮、謝建台、卓群恭、王家麟、丁望賢、游鎮烽、陳皓君、王勝盟、蔡東湖、陳月枝、卓怡孜，2015，《質譜分析技術原理與應用》，共512頁，新北市：全華圖書。
Chapter of Publication
Paper of Conference (or Symposium)
  1. E. Gizaw, M. C. Tseng*; Y. J. Chen*, 2018, “Thin-layer Chromatography Coupled with Nano-matrix Bsed MALDI-TOF Mass Spectrometry for Structural Elucidation of Carbohydrates”, paper presented at 22th International Mass Spectrometry Conference., 義大利佛羅倫斯: International Mass Spectrometry, 2018-08-25 ~ 2018-08-31.
  2. M. C. Tseng; L. C. Lee; J. H. Wang; Y. J. Chen; C. P. W. Chung, 2017, “Structural Characterization of Glycoconjugates by Using Functional Carbon Materials with Hydrolysis Reaction in MALDI-MS”, paper presented at 16 th Human Proteome Organization World Congress, Ireland、Dublin: Human Proteome Organization, 2017-09-16 ~ 2017-09-21.
  3. Mei-Chun Tseng, Ling-Chieh Lee, Jia-Hui Wang, Yu-Ju Chen, Cedric Po-Wen Chung, 2016, “Functional Carbon Surface for Structural Characterization of Disaccharides by Matrix-assisted Laser Desorption/Ionization-Mass Spectrometry”, paper presented at 21th International Mass Spectrometry Conference, Canada: IMSC, 2016-08-20 ~ 2016-08-26.
  4. Mei-Chun Tseng, Rofeamor P. Obena,Yi-Chi Ho, Ying-Ru Luo, Chun-Cheng Lin, Yu-Ju Chen, Ming-Ren Fuh, 2015, “Nanoparticle Seed-Layer for Laser Desorption/Ionization Mass Spectrometry in the Quantification of Various Polarity Drugs ”, paper presented at The 2015 International Chemical Congress of Pacific Basin Societies, HAWAII: PACIFICHEM 2015, 2015-12-14 ~ 2015-12-20.
  5. M. C. Tseng; C. S. Sun; C. H. Hsu; G. C. H. Lin; C. Y. H. Wang; Y. R. Chen; J. J. T. Huang, 2014, “Ion-Mobility Mass Spectrometry Analysis of the Conformational Conversion of Amyloid Aggregation”, paper presented at 20th International Mass Spectrometry Conference, Switzerland: International Mass Spectrometry, 2014-08-24 ~ 2014-08-29.
  6. M. C. Tseng; C. S. Sun; C. Y. H. Wang; J. J. T. Huang; Y. R. Chen*, 2013, “The Conformational Conversion of Amyloid Derived from TDP-43 Revealed by Ion Mobility–Mass Spectrometry”, paper presented at 5th EMBO Meeting 2013 – Advancing the life science, Netherlands: EMBO, 2013-09-21 ~ 2013-09-24.
  7. Wei Hsu, Yi-Chi Ho,Mei-Chun Tseng, An-Kai Su, Ping-Yu Lin, Huan-Ting Wu, Chun-Cheng Lin, Ming-Ren Fuh, Yu-Ju Chen*, 2012, “Metal Modified Nanoparticle as a Probe for Quantitative Analysis of Clodronate Drug by MALDI-MS in Human Plasma”, paper presented at 19th International Mass Spectrometry Conference, Japan: International Mass Spectrometry, 2012-09-15 ~ 2012-09-21.
  8. I.C. Li, Rofe-Amor, M.C. Tseng, Y.W. Lu, C.C. Lin, Y.J. Chen*, 2012, “Structure Characterization of Isomeric Oligosaccharide by One-step Tunable Nanoparticles-Assistanted MALDI TOF MS”, paper presented at 60th American Society Mass Spectrometry, Vancouver: American Society Mass Spectrometry, 2012-05-19 ~ 2012-05-24.
  9. Wei Hsu, Yi-Chi Ho, Mei-Chun Tseng, An-Kai Su, Huan-Ting Wu, Chun-Cheng Lin, Ming-Ren Fuh, Yu-Ju Chen*, 2011, “ Quantitative Analysis of Dichloromethylene-Bisphosphonic Acid”, paper presented at 59th ASMS Conference on Mass Spectrometry, 美國，丹佛: American Society for Mass Spectrometry, 2011-06-04 ~ 2011-06-10.
  10. Ying-Ru Luo, Mei-Chun Tseng, Ying-Wei Lu, Chun-Cheng Lin, Yu-Ju Chen, Ming-Ren Fuh*, 2010, “Nanoparticle-Assisted Seed-Layer Sample Preparation for Quantification of Small Molecule by MALDI-TOF MS”, paper presented at 58th ASMS Conference on Mass Spectrometry, Salt Lake City,USA: American Society for Mass Spectrometry, 2010-05-22 ~ 2010-05-27.
  11. Chao-Jung Chen, Mei-Chun Tseng, Yet-Ran Chen*, 2010, “A Tunnel Frit: a Robust and Low Backpressure On-Column Frit for nanoUPLC-MS/MS Applications”, paper presented at 58rd ASMS Conference on Mass Spectrometry, USA: American Society for Mass Spectrometry, 2010.
  12. Mei-Chun Tseng, Rofe-Amor Obena, Ying-Wei Lu, Po-Chiao Lin,Chun-Cheng Lin, Yu-Ju Chen*, 2009, “Background-Free MALDI Analysis for Accurate Small Characterization”, paper presented at 18th International Mass Spectrometry Conference, Bremen, Germany: International Mass Spectrometry, 2009-08-30 ~ 2009-09-04.
  13. Han-Tsung Huang, Mei-Chun Tseng, Wei Hsu, Po-Chiao Lin, Ching-Wen Ho, Chun-Cheng Lin, Chun-Hung Lin, Yu-Ju Chen*, 2009, “Inhibitor Encapsulated Nanoparticles for Rapid Fucosidase Identification and Binding-Eptiopes Mapping”, paper presented at 57th ASMS Conference on Mass Spectrometry, Philadelphia, USA: American Society for Mass Spectrometry, 2009-05-30 ~ 2009-06-04.
  14. Chao-Jung Chen, Mei-Chun Tseng, Yet-Ran Chen*, 2009, “A Rapid Visualized Indicator of Surfactant Residual (VISR) for the Generic and Membrane Proteomics Application”, paper presented at 57th ASMS Conference on Mass Spectrometry, Philadelphia, USA: American Society for Mass Spectrometry, 2009-05-30 ~ 2009-06-04.
  15. Ying Lan Chen, Mei-chun Tseng, Yet-ran Chen*, 2009, “Development of the Plant Signaling Peptides Discovery Platform Using Mass Spectrometry”, paper presented at 57th ASMS Conference on Mass Spectrometry, Philadelphia, USA: American Society for Mass Spectrometry, 2009-05-30 ~ 2009-06-04.
  16. Rofe-Amor Obena, Mei-chun Tseng, Ying-Wei Lu, Po-Chiao Lin, Chun-Cheng Lin, Yu-Ju Chen*, 2009, “Nanoparticle-Induced Fragmentation for Structure Determination of Carbohydrates by MALDI-TOF MS”, paper presented at 57th ASMS Conference on Mass Spectrometry, Philadelphia, USA: American Society for Mass Spectrometry, 2009-05-30 ~ 2009-06-04.
  17. Chi-Yi Ho, Po-Chiao Lin, Chun-Cheng Lin, Ying-Wei Lu, Mei-Chun Tseng, Yu-Ju Chen, Ming-Ren Fuh*, 2009, “Quantification of Illegal Drugs in Urine Using Magnetic Nanoprobes and MALDI-TOF MS”, paper presented at 57th ASMS Conference on Mass Spectrometry, Philadelphia, USA: American Society for Mass Spectrometry, 2009-05-30 ~ 2009-06-04.
  18. Mei-Chun Tseng, Rofe-Amor Obena, Ying-Wei Lu, Po-Chiao Lin, Chia-Chun Chen, Chun-Cheng Lin, Yu-Ju Chen*, 2008, “Functionalized Magnetic Nanoparticle for Rapid Screening and Structure Determination of Small Molecules by MALDI MS”, paper presented at 56rd ASMS Conference on Mass Spectrometry, Denver, USA: American Society for Mass Spectrometry, 2008-05-31 ~ 2008-06-06.
  19. Han-Tsung Huang, Mei-Chun Tseng, Shu-Hua Chen, Po-Chiao Lin, Ching-Wen Ho, Der-Lii Tzou, Chun-Cheng Lin, Chun-Hung Lin, Yu-Ju Chen*, 2008, “Epitope mapping for carbohydrate-protein interaction by nanoprobe-based affinity mass spectrometry ”, paper presented at 56th ASMS Conference on Mass Spectrometry, Denver, USA: American Society for Mass Spectrometry, 2008-05-31 ~ 2008-06-06.
  20. Mei-Chun Tseng, Po-Chiao Lin, An-Kai Su, Yu-Ju Chen, Chun-Cheng Lin*, 2007, “Functionalized Magnetic Nanoparticles for small-Molecule Isolation, Identification, and Quantification using MALDI-TOF mass spectrometry”, paper presented at 55th ASMS Conference on Mass Spectrometry, Indiana, USA: American Society for Mass Spectrometry, 2007-06-02 ~ 2007-06-07.
  21. Mei-Chun Tseng, Gour-Rong Her*, 2006, “Analysis of Gangliosides by Capillary Electrophoresis / Electrospray Ionization Mass Spectrometry with Volatile Buffers”, paper presented at 54th ASMS Conference on Mass Spectrometry, Seattle, USA: American Society for Mass Spectrometry, 2006-05-28 ~ 2006-06-01.
Science Report
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