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Hsiao-hua Yu (尤嘯華)

Organic and Polymer Materials, Nanobiotechnology, Cell Materials Interface

Hsiao-hua Yu (尤嘯華)


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Research Fellow(2019-);Associate Research Fellow (2014-2019);B.S., Department of Chemistry, National Taiwan University (1992-1996);Teaching assistant, Department of Chemistry, National Taiwan University (1996-1997); Ph.D., Department of Chemistry, Massachusetts Institute of Technology (1997-2003);Postdoctoral Researcher, Department of Chemical Engineering, Massachusetts Institute of Technology (2003-2004);Senior Research Scientist, Institute of Bioengineering and Nanotechnology, Singapore (2004-2008); Initiative Research Scientist, RIKEN, Japan(2008-2013);Associate Chief Scientist, RIKEN, Japan(2013-2014); Visiting Undergraduate Researcher, The Scripps research Institute (1995);Adjunct Assistant Professor, Division of Materials Technology, School of Materials Science and Engineering, Nanyang Technological University, Singapore (2008);Adjunct Associate Professor, Department of Electronic Chemistry, Interdisciplinary Graduate School of Science and Technology, Tokyo Institute of Technology, Japan (2010-2014);Academic Year 2nd Term Young Scholar Abroad Oustanding Scholarship from Foundation For The Advancement of Oustanding Scholarship(2013);
Research Interests

Design molecular architecture toward target functions and utilize green and efficient approaches to synthesize these molecules.
Control the nanostructure assembly for formation of nanomaterials and add in additional property-control components to derive desired properties.
Demonstrate the target functions (biomedical applications, energy, catalysis) and direct the materials for real applications.

Selected Publications
  1. Lin, H.-A.; Luo, S.-C.; Zhu, B.; Chen, C.; Yamashita, Y.; Yu, H.-h. Molecular structures or nano-assemblies? the deciding factor of surface properties in poly(3,4-ethylenedioxythiophene) nanorod array. Adv. Funct. Mater. 2013, 23, 3212.
  2. Hou, S.; Zhao, H.; Zhao, L.; Shen, Q.; Wei, K. S.; Suh D. Y.; Nakao, A.; Xiong B.; Luo, S.-C.; Tseng, H.-R.; Yu, H.-h. Capture and stimulated release of circulating tumor cells on polymer grafted silicon nanostructures. Adv. Mater. 2013, 25, 1547. (Press coverage by National Cancer Institute,, Sciencedaily.con, Nikkan Kogyo Shimbun, Nihon Keizai Shimbun, Yahoo Japan News, etc. RIKEN Research "Highlight of the Month". Selected as inside cover for Advanced Materials)
  3. Zhao, H.; Liu, C.-H.; Luo, S.-C.; Zhu, B.; Wang, T.-H.; Hsu, H.-F.; Yu, H.-h. Facile syntheses of dioxythiophene-based conjugated polymers by direct C-H arylation. Macromolecules 2012, 45, 7783.
  4. Luo, S.-C.; Zhu, B.; Kantchev, E. A. B.; Zhu, B.; Siang, Y. W.; Yu, H.-h. Tunable, dynamic and electrically stimulated lectin-carbohydrate recognition on a glycan-grafted conjugated polymer. Chem. Commun. 2012, 48, 6942.
  5. Sekine, J.; Luo, S.-C.; Wang, S.; Zhu, B.; Tseng, H.R.; Yu, H.-h. Functionalized conducting polymer nanodots for enhanced cell capturing: the synergistic effect of capture agents and nanostructures. Adv. Mater. 2011, 23, 4788. (Highlighted by RIKEN Research)
  6. Liu, C.-Y.; Zhao, H.; Yu, H.-h. Efficient synthesis of 3,4-Ethylenedioxythiophene (EDOT)-based functional π-conjugated molecules through direct C-H bond arylations. Org. Lett. 2011, 13, 4068.
  7. Luo, S.-C.; Zhu, B.; Nakao, A.; Nakatomi, R.; Yu, H.-h. Functionalized conducting polymer nano-networks from controlled oxidation polymerization toward cell engineering. Adv. Eng. Mater. (Advanced Biomaterials) 2011, 13, B423. (Invited article by E-MRS 2010 Spring Meeting. Selected as section cover for Advanced Biomaterials)
  8. Luo, S.-C.; Liour, S. S.; Yu, H.-h. Perfluoro-functionalized PEDOT films with controlled morphology as superhydrophobic coatings and biointerfaces with enhanced cell adhesion. Chem. Commun. 2010, 46, 4731.
  9. Luo, S.-C.; Mohamed Ali, E.; Tansil, N. C.; Yu, H.-h.; S. Gao, Kantchev, E. A. B.; Ying, J. Y. PEDOT nanobiointerfaces: thin, ultrasmooth, and functionalized poly(3,4-ethylenedioxythiophene) films with in vitro and in vivo biocompatibility. Langmuir 2008, 24, 8071.

Update: 2015-03-23

Journal Paper
  1. Syed Atif Ali, Hailemichael Ayalew, Bhaskarchand Gautam, Baskar Selvaraj, Jia-Wei She, Jayakrishnan Aerathupalathu Janardhanan, Hsiao-hua Yu * Detection of SARS-CoV-2 Spike Protein using Micropatterned 3D-Poly(3,4 Ethylenedioxythiophene) Nanorods Decorated with Gold Nanoparticles. ACS APPLIED MATERIALS & INTERFACES 2024-01-09, .
  2. Ali Syed Atif, Ayalew Hailemichael, Gautam Bhaskarchand, Selvaraj Baskar, She Jia-Wei, Janardhanan Jayakrishnan Aerathupalathu, Yu Hsiao-hua Detection of SARS-CoV-2 Spike Protein Using Micropatterned 3D Poly(3,4-Ethylenedioxythiophene) Nanorods Decorated with Gold Nanoparticles. ACS Applied Materials & Interfaces 2024,  .
  3. Udesh Dhawan*, Wei-Li Wang, Yuh-Charn Lin, Ruey-Bing Yang, Matthew J. Dalby, Manuel Salmeron-Sanchez*, Hsiao-hua Yu* Mechanostimulation-induced integrin αvβ6 and latency associated peptide coupling activates TGF-β and regulates cancer metastasis and stemness. Nano Today 2023-0650, 101882.
  4. Gautam Bhaskarchand, Huang Meng-Ru, Ali Syed Atif, Yan Ai-Ling, Yu Hsiao-hua, Chen Jiun-Tai Smart Thermoresponsive Electrospun Nanofibers with On-Demand Release of Carbon Quantum Dots for Cellular Uptake. ACS Applied Materials & Interfaces 2022-08-2214(35), 40322-40330.
  5. Zhu Yicheng, Lin Hsing-An*, Zhang Shouyan, Pan Qichao, Qian Sihao, Zhang Shuhua, Zhang Yaqiong, Luo Shyh-Chyang*, Yu Hsiao-Hua*, Zhu Bo* A straightforward strategy to spatially organize repulsive and attractive cues on Zwitterionic PEDOTs. Colloid and Interface Science Communications 2022-08-0550, 100656.
  6. Jayakrishnan Aerathupalathu Janardhanan, Ying-Lin Chen, Chun-Ting Liu, Hsueh-Sheng Tseng, Po-I Wu, Jia-Wei She, Yu-Sheng Hsiao*, Hsiao-hua Yu* Sensitive detection of sweat cortisol using an organic electrochemical transistor featuring nanostruc-tured poly(3,4-ethylenedioxythiophene) derivatives in the channel layer. ANALYTICAL CHEMISTRY 2022-05-1994, 7584-7593.
  7. Na Sun, Benjamin V. Tran, Zishan Peng, Jing Wang, Ceng Zhang, Peng Yang, Tiffany X. Zhang, Josephine Widjaja, Ryan Y. Zhang, Wenxi Xia, Alexandra Keir, Jia-Wei She, Hsiao-hua Yu, Jing-Jong Shyue, Hongguang Zhu, Vatche G. Agopian, Renjun Pei,* James S. Tomlinson, Jeffrey A Toretsky, Steven J. Jonas, Noah Federman, Shaohua Lu,* Hsian-Rong Tseng,* and Yazhen Zhu* Coupling Lipid Labeling and Click Chemistry Enables Isolation of Extracellular Vesicles for Noninvasive Detection of Oncogenic Gene Alterations. ADVANCED SCIENCE 2022-03-099, 2105853.
  8. Jayakrishnan Aerathupalathu Janardhanan, Anusha Valaboju, Udesh Dhawan, Tharwat Hassan Mansoure, Ching-Cher Sanders Yan, Chou-Hsun Yang, Bhaskarchand Gautam, Chao-Ping Hsu*, Hsiao-hua Yu* Molecular and nano structures of chiral PEDOT derivatives influence the enantiorecognition of biomolecules. In silico analysis of chiral recognition. The Analyst 2021-12, 146(23) 7118-7125.
  9. Bhaskarchand Gautam, Syed Atif Ali, Jiun-Tai Chen*, Yu Hsiao-hua* Hybrid "Kill and Release" Antibacterial Cellulose Papers Obtained via Surface-Initiated Atom Transfer Radical Polymerization. ACS Applied Bio Materials 2021-10, 4(11) 7893-7902.
  10. Mohamed Hammad Elsayed, Jayachandran Jayakumar, Mohamed Abdellah, Tharwat Hassan Mansoure, Kaibo Zheng, Ahmed M. Elewa, Chih-Li Chang, Li-Yu Ting, Wei-Cheng Lin, Hsiao-hua Yu, Wen-Hsin Wang, Chih-Chia Chung, Ho-Hsiu Chou* Visible-light-driven hydrogen evolution using nitrogen-doped carbon quantum dot-implanted polymer dots as metal-free photocatalysts. Applied Catalysis B: Environmental 2021-04283, 119659.
  11. Bhaskarchand Gautam, Hsiao-Hua Yu  Self-Cleaning Cotton Obtained after Grafting Thermoresponsive Poly(N-vinylcaprolactam) through Surface-Initiated Atom Transfer Radical Polymerization. POLYMERS 2020-122020, 12(12).
  12. Bhaskarchand Gautam Hailemichael Ayalew Udesh Dhawan Jayakrishnan Aerathupalathu Janardhanan Hsiao‐hua Yu Layer‐by‐layer assembly and electrically controlled disassembly of water‐soluble Poly(3,4‐ethylenedioxythiophene) derivatives for bioelectronic interface. JOURNAL OF THE CHINESE CHEMICAL SOCIETY 2020-0867(9), 1602-1610.
  13. Ya-Qiong ZhangYa-Qiong Zhang State Key Laboratory for Modification of Chemical Fibers and Polymer Materials & College of Materials Science and Engineering, Donghua University, 2999 Renmin North Road, Songjiang, Shanghai 201600, China School of Materials Science and Engineering, Shanghai University, 99 Shangda Road, Baoshan, Shanghai 200444, China More by Ya-Qiong Zhang , Hsing-An Lin*, Qi-Chao Pan, Si-Hao Qian, Shu-Hua Zhang, Gao Qiu, Shyh-Chyang Luo*, Hsiao-hua Yu*, and Bo Zhu* Tunable Protein/Cell Binding and Interaction with Neurite Outgrowth of Low-Impedance Zwitterionic PEDOTs. ACS APPLIED MATERIALS & INTERFACES 2020-022020, 12.
  14. Dhawan Udesh, Wang Wei‐Li, Gautam Bhaskarchand, Aerathupalathu Janardhanan Jayakrishnan, Hsiao Po‐Chiang, Tu Hsiung‐Lin, Yu Hsiao‐Hua Mechanotactic Activation of TGF‐β by PEDOT Artificial Microenvironments Triggers Epithelial to Mesenchymal Transition. Advanced Biosystems 2020-01,  1900165.
  15. Jiantong Dong, Yu Jen Jan, Ju Cheng, Ryan Y. Zhang, Meng Meng, Matthew Smalley, Pin-Jung Chen, Xinghong Tang, Patrick Tseng, Lirong Bao, Tzu-Yang Huang, Dongjing Zhou, Yupin Liu, Xiaoshu Chai, Haibo Zhang, Anqi Zhou, Vatche G. Agopian, Edwin M. Posadas, Jing-Jong Shyue, Steven J. Jonas, Paul S. Weiss, Mengyuan Li*, Guangjuan Zheng*, Hsiao-hua Yu*, Meiping Zhao*, Hsian-Rong Tseng*, Yazhen Zhu* Covalent chemistry on nanostructured substrates enables noninvasive quantification of gene rearrangements in circulating tumor cells. SCIENCE ADVANCES 2019-075, eaav9186.
  16. Jia-An Chou†, Chieh-Lin Chung†, Po-Cheng Ho†, Chun-Hao Luo, Yu-Han Tsai, Chung-Kuan Wu, Chiung-Wen Kuo, Yu-Sheng Hsiao*, Hsiao-hua Yu* and Peilin Chen* Organic Electrochemical Transistors/SERS-Active Hybrid Biosensors Featuring Gold Nanoparticles Immobilized on Thiol-Functionalized PEDOT Films. frontiers in Chemistry 2019-04, 7:281.
  17. Tara Bahadur K. C., Seiichi Tada, Liping Zhu, Takanori Uzawa, Noriko Minagawa, Shyh-Chyang Luo, Haichao Zhao, Hsiao-hua Yu, Toshiro Aigaki, Yoshihiro Ito* In vitro selection of electrochemical peptide probes using bioorthogonal tRNA for influenza virus detection. CHEMICAL COMMUNICATIONS 2018-05-2154(21), 5201-5204.
  18. Hsing-An Lin, Bo Zhu,* Yu-Wei Wu, Jun Sekine, Aiko Nakao, Shyh-Chyang Luo,* Yoshiro Yamashita,* Hsiao-Hua Yu* Dynamic Poly(3,4-ethylenedioxythiophene)s Integrate Low Impedance with Redox-Switchable Biofunction. ADVANCED FUNCTIONAL MATERIALS 2018-03-2128(12), 1703890.
  19. Mo‐Yuan Shen, Jie‐Fu Chen, Chun‐Hao Luo, Sangjun Lee, Cheng‐Hsuan Li, Yung‐Ling Yang, Yu‐Han Tsai, Bo‐Cheng Ho, Li‐Rong Bao, Tien‐Jung Lee, Yu Jen Jan, Ya‐Zhen Zhu, Shirley Cheng, Felix Y. Feng, Peilin CHen, Shuang Hou*, Vatche Agopian*, Yu‐Sheng Hsiao*,  Glycan Stimulation Enables Purification of Prostate Cancer Circulating Tumor Cells on PEDOT NanoVelcro Chips for RNA Biomarker Detection. ADVANCED HEALTHCARE MATERIALS 2018-02-077(3), 1700701.
  20. Yu Jen Jan, Jie-Fu Chen, Yazhen Zhu, Yi-Tsung Lu, Szu Hao Chen, Howard Chung, Matthew Smalley, Yen-Wen Huang, Jiantong Dong, Li-Ching Chen, Hsiao-Hua Yu, James S. Tomlinson, Shuang Hou, Vatche G. Agopian, Edwin M. Posadas, Hsian-Rong Tseng* NanoVelcro rare-cell assays for detection and characterization of circulating tumor cells. ADVANCED DRUG DELIVERY REVIEWS 2018-02-01125, 78-93.
  21. Xiaomeng Liu, Tongfang Xiao, Fei Wu, Mo-Yuan Shen, Meining Zhang*, Hsiao-hua Yu*, Lanqun Mao* Ultrathin Cell-Membrane-Mimic Phosphorylcholine Polymer Film Coating Enables Large Improvements for In Vivo Electrochemical Detection. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2017-08-0356, 11802-11806.
  22. Shuang Hou, Jie-Fu Chen, Min Song, Yazhen Zhu, Yu Jen Jan, Szu Hao Chen, Tzu-Hua Weng, Dean-An Ling, Shang-Fu Chen, Tracy Ro, An-Jou Liang, Tom Lee, Helen Jin, Man Li, Lian Liu, Yu-Sheng Hsiao, Peilin Chen, Hsiao-Hua Yu, Ming-Song Tsai*, 
Margareta D. P Imprinted NanoVelcro Microchips for Isolation and Characterization of Circulating Fetal Trophoblasts: Toward Noninvasive Prenatal Diagnostics. ACS NANO 2017-07-1911, 8167-8177.
  23. Zha Li, Pan He, Hui Chong, Akihiro Furube, Kazuhiko Seki, Hsiao-hua Yu, Keisuke Tajima, Yoshihiro Ito*, Masuki Kawamoto* Direct Aqueous Dispersion of Carbon Nanotubes Using Nanoparticle-Formed Fullerenes and Self-Assembled Formation of p/n Heterojunctions with Polythiophene. ACS Omega 20172(4), 1625-1632.
  24. Jin-sil Choi, Yazhen Zhu, Hongsheng Li, Parham Peyda, Thuy Tien Nguyen, Mo Yuan Shen, Yang Michael Yang, Jingyi Zhu, Mei Liu, Mandy M. Lee, Shih-Sheng Sun, Yang Yang, Hsiao-hua Yu, Kai Chen*, Gary S. Chuang*, and Hsian-Rong Tseng* Cross-Linked Fluorescent Supramolecular Nanoparticles as Finite Tattoo Pigments with Controllable Intradermal Retention Times. ACS NANO 2016-11-3011, 153-162.
  25. Ching-Yuan Liu , Hui Chong , Hsing-An Lin , Yoshiro Yamashita , Bin Zheng , Kuo-Wei Huang , Daisuke hashizume and Hsiao-hua Yu* Palladium-Catalyzed Direct C-H Arylations of Dioxythiophenes Bearing Reactive Functional Groups: A Step-Economical Approach for Functional π-Conjugated Oligoarenes. ORGANIC & BIOMOLECULAR CHEMISTRY 2015-0613, 8505-8511.
  26. Hui Chong, Hsing-An Lin, Mo-Yuan Shen, Ching-Yuan Liu, Haichao Zhao, and Hsiao-hua Yu* Step-Economical Syntheses of Functional BODIPY-EDOT π-Conjugated Materials through Direct C–H Arylation. ORGANIC LETTERS 2015-0617 (13), 3198-3201.
  27. Pan He, Kyoji Hagiwara, Hui Chong, Hsiao-hua Yu*, Yoshihiro Ito* Low-Molecular-Weight Polyethyleneimine Grafted Polythiophene for Efficient siRNA Delivery. BIOMED RESEARCH INTERNATIONAL 2015-06, Article ID 406389.
  28. Yu-Sheng Hsiao*, Bo-Cheng Ho, Hong-Xin Yan, Chiung-Wen Kuo, Di-Yen Chueh, Hsiao-hua Yu and Peilin Chen* Integrated 3D conducting polymer-based bioelectronics for capture and release of circulating tumor cells. JOURNAL OF MATERIALS CHEMISTRY B 2015-053, 5103-5110.
  29. Zunfu Ke*, Millicent Lin, Jie-Fu Chen, Jin-sil Choi, Yang Zhang, Anna Fong, An-Jou Liang, Shang-Fu Chen, Qingyu Li, Wenfeng Fang, Pingshan Zhang, Mitch A. Garcia, Tom Lee, Min Song, Hsing-An Lin, Haichao Zhao, Shyh-Chyang Luo, Shuang Hou*, Hsiao-hua Yu* Programming Thermoresponsiveness of NanoVelcro Substrates Enables Effective Purification of Circulating Tumor Cells in Lung Cancer Patients. ACS Nano 2015-019(1), 62-70.
  30. Jae-Eun Lee, Shyh-Chyang Luo, Bo Zhu, Joon Won Park*, Hsiao-hua Yu* Nanoscale analysis of functionalized polythiophene surfaces: the effects of electropolymerization methods and thermal treatment. RSC Advances 2014-114, 62666-62672.
  31. Bo Zhu, Shyh-Chyang Luo, Haichao Zhao, Hsing-An Lin, Jun Sekine, Aiko Nakao, Chi Chen, Yoshiro Yamashita, Hsiao-hua Yu* Large enhancement in neurite outgrowth on a cell membrane-mimicking conducting polymer. Nature Communications 2014-075 , 4523.
  32. Jae-Eun Lee, Ju-Won Kwak, Joon Won Park, Shyh-Chyang Luo, Bo Zhu, Hsiao-hua Yu* Nanoscale Analysis of a Functionalized Polythiophene Surface by Adhesion Mapping. ANALYTICAL CHEMISTRY 2014-0686, 6865−6871.
  33. Bor-Ran Li, Mo-Yuan Shen, Hsiao-hua Yu, Yaw-Kuen Li* Rapid construction of an effective antifouling layer on a Au surface via electrodeposition. CHEMICAL COMMUNICATIONS 2014-0550, 6793-6796.
  34. Yu-Sheng Hsiao*, Shyh-Chyang Luo, Shuang Hou, Bo Zhu, Jun S ekine, Chiung-Wen Kuo, Di-Yen Chueh, Hsiao-hua Yu*, Hsian-Rong Tseng*, Peilin Chen* 3D Bioelectronic Interface: Capturing Circulating Tumor Cells onto Conducting Polymer-Based Micro/Nanorod Arrays with Chemical and Topographical Control. SMALL 2014-0410(15), 3012–3017.
  35. Zha Li, Takanori Uzawa, Haichao Zhao, Shyh-Chyang Luo, Hsiao-hua Yu, Eiry Kobatake, Yoshihiro Ito* In vitro selection of peptide aptamers using a ribosome display for a conducting polymer. JOURNAL OF BIOSCIENCE AND BIOENGINEERING 2014117(4), 501-503.