主框架
:::
陳長謙 (Sunney I. Chan)

生物化學

陳長謙 (Sunney I. Chan)

    886-2-55728654
    886-2-27831237
    sunneychanyahoo.com
    陳長謙 實驗室
(另開視窗)
特聘講座(95年~迄今);特聘研究員(86年~95年);46年自柏克萊加州大學化工系畢業;49年獲柏克萊加州大學化學系博士;49至50年任哈佛大學博士後研究;50至52年任加州大學河邊分校化學系助教授;52至53年轉任加州理工學院化學系助教授;53至57年任副教授;57至81年任教授;81年起擔任加州理工學院George Grant Hoag生物物理化學榮譽講座教授迄今;在就任加州理工學院教授期間,並曾於民國58年任牛津大學訪問教授; 65年任柏克萊加州大學訪問學者;66至69年及78至83年任加州理工學院化學系主任;70年任加州史丹佛大學訪問教授;72至87年任美國化學會誌副總編輯;76至78年任加州理工學院學務主管;80至83年任美國國家衛生研究院(NIH)物理生物化學研究組主席;83至85年任香港中文大學訪問教授;86至88年任中央研究院化學研究所所長;88至92年中央研究院副院長;85年至今任香港中文大學名譽教授;77年7月當選為中央研究院院士;並獲選81年American Association for Advancement of Science Fellow;82年獲Wilson Wang 傑出國際教授,另獲多項講座及獎項;民國86年應李遠哲院長邀請返國,為國際知名之核磁共振譜學專家暨生物細胞膜及膜蛋白權威;101獲第十四屆張昭鼎教授紀念講座;
研究領域

主要的研究方向為生物物理化學;細胞膜蛋白的結構及功能;核磁共振光譜;電子自旋光譜;X光繞射譜;生物無機化學;蛋白質結構;生物能量。

A tricopper complex capable of efficient conversion of methane into methanol at room temperature



重要獎項及殊榮
  • "總統科學獎"  (2021)
  • "台灣生物無機學會終生成就獎"  (2018)
  • "2018年台灣石化合成公司-學術貢獻獎"  (2018)
  • "台灣磁共振學會終身成就獎"  (2016)
  • "Acharya P.C. Ray Memorial Lecture Award in Chemistry"  (2015)
  • "第十四屆張昭鼎教授紀念講座"  (2012)
  • "N.C. Yang Memorial Lecture"  (2012)
  • "Elected Fellow of the International Academy of Physical Sciences"  (2011)
  • "美國國家人文暨科學院院士"  (2010)
  • "Elected Fellow of the Biophysical Society"  (2005)
  • "美國生物物理學學會CBNet獎章"  (2005)
  • "Fellow of Biophysical Society (U. S. A.)"  (2004)
  • "美國生物化學化學暨分子生物學學會William C. Rose獎章"  (2004)
  • "第三世界科學院院士"  (2004)
代表作
  1. Fellow, American Physical Society,1987.
  2. Elected Member of Academia Sinica, 1988.
  3. ASCIT Teaching Award, California Institute of Technology, 1991.
  4. Fellow of the American Association for the Advancement of Science, 1992.
  5. Wilson T. S. Wang Distinguished International Professor, Chinese University of Hong Kong, 1993.
  6. Richard M. Badger Teaching Prize, California Institute of Technology, 1994.
  7. Doctor of Science honoris causea, Hong Kong Baptist University, 2003.
  8. William C. Rose Award, American Society of Biochemistry and Molecular Biology, 2004.
  9. Member, Academy of Sciences for the Developing World, 2004.
  10. Fellow, Biophysical Society USA, 2004.
  11. CBNet Award in Biophysics, Biophysical Society, 2005.
  12. Fellow of the American Academy of Arts and Sciences, 2010.
  13. Fellow of the International Academy of Physical Sciences, 2011.

Selected Publications
  1. Liu, C.-C.; Janmanchi, D.; Wen, D.-R.; Oung, J.-N.; Mou, C.-Y.; Yu, S. S.-F.; Chan, S. I. Catalytic oxidation of light alkanes mediated at room temperature by a tricopper cluster complex immobilized in mesoporous silica nanoparticles. ACS Sustainable Chem. Eng. 2018, 6, 5431.
  2. Thiyagarajan, N.; Janmanchi, D.; Tsai, Y.-F.; Wanna, W. H.; Ramu, R.; Chan, S. I.; Zen, J.-M.; Yu, S. S.-F. A carbon electrode functionalized by a tricopper cluster complex: Overcoming overpotential and production of hydrogen peroxide in the oxygen reduction reaction. Angew.Chem. Int. Ed. 2018, 57, 3612.
  3. Wang, V. C.-C.; Maji, S.; Chen, P. P.-Y.; Lee, H. K.; Yu, S. S.-F.; Chan, S. I. Alkane oxidation: Methane monooxygenases, related enzymes, and their biomimetics. Chem. Rev. 2017, 117, 8574.
  4. Liu, C.-C.; Ramu, R.; Chan, S. I.; Mou, C.-Y.; Yu, S S.-F. Chemistry in confined space: a strategy for selective oxidation of hydrocarbons with high catalytic efficiencies and conversion yields under ambient conditions. Catal. Sci. Technol. 2016, 6, 7623.
  5. Liu, C.-C.; Mou, C.-Y.; Yu, S. S.-F.; Chan, S. I. Heterogeneous formulation of the tricopper complex for efficient catalytic conversion of methane into methanol at ambient temperature and pressure. Energy Environ. Sci. 2016, 9, 1361.
  6. Pham, M. D.; Lin, Y.-P.; Vuong, Q. V.; Nagababu, P.; Chang, B. T.-A.; Ng, K. Y.; Chen, C.-H.; Han, C.-C.; Chen, C.-H.; Yu, S. S.-F; Chan, S. I. Inactivation of the particulate methane monooxygenase (pMMO) from Methylococcus capsulatus (Bath) by acetylene. Biochim. Biophys. Acta 2015, 1854, 1843.
  7. Chen, K. H.-C.; Chuankhyan, P.; Wu, H.-H.; Chen, C.-J.; Fukuda, M.; Yu, S. S.-F.; Chan, S. I. The bacteriohemerythrin from Methylococcus capsulatus (Bath): Crystal structures reveal Leu114 regulates a water tunnel. J. Inorg. Biochem. 2015, 150,
  8. Nagababu, P.; Yu, S. S.-F.; Maji, S.; Ramu, R.; Chan, S. I. An Efficient Catalyst for Controlled Oxidation of C1-C6 Hydrocarbons under Ambient Conditions. Catal. Sci. Tech. 2014, DOI: 10.1039/c3cy00884c.
  9. Chen, P. P.-Y.; Nagababu, P.; Yu, S. S.-F.; Chan, S. I. Development of the Tricopper Cluster as a Catalyst for Efficient Conversion of Methane into Methanol. ChemCatChem minireview 2014, 6, 429. DOI: 10.1002/cctc.201300473.
  10. Chan, S.I. Opportunities for Innovation in Chemical Education. The Chemical Education Journal 2013, 15, 1.
  11. Pham, M. D.; Yu, S. S.-F.; Han, C.-C.; Chan, S. I. Improved Mass Spectrometric Analysis of Membrane Proteins Based on Rapid and Versatile Sample Preparation on Nanodiamond Particles. Anal. Chem. 2013, 85, 6748.
  12. Chan, S. I.; Lu, Y.-J.; Nagababu, P.; Maji, S.; Hung, M.-C.; Lee, M. M.; Hsu, I.-J.; Pham, M. D.; Lai, J. C.-H.; Ng, K. Y.; Ramalingam, S.; Yu, S. S.-F.; Chan, M. K. Efficient Oxidation of Methane to Methanol by Dioxygen Mediated by Tricopper Clusters. Angew. Chem. Int. Ed. 2013, 52, 3731.
  13. Nagababu, P.; Maji, S.; Kumar, M. P.; Chen, P. P.-Y.; Yu, S. S.-F.; Chan, S. I. Efficent Room-temperature Oxidation of Hydrocarbons Mediated by Tricopper Cluster Complexes with Different Ligands. Adv. Synth. Catal. 2012, 354, 3275.
  14. Chan, S. I.; Chien, C. Y.-C.; Yu, C. S.-C.; Nagababu, P.; Maji, S.; Chen, P. P.-Y. Efficient Catalytic Oxidation of Hydrocarbons Mediated by a Tricopper Cluster under Mild Conditions. J. Catalysis 2012, 293, 186.
  15. Maji, S.; Lee, J. C.-M.; Lu, Y.-J.; Chen, C.-L.; Hung, M.-C.; Chen, P. P.-Y.; Yu, S. S.-F.; Chan, S. I. Activation of a Trinuclear CuICuICuI Cluster Capable of Mediating Facile Oxidation of Organic Substrates: Competition between O-Atom Transfer and Abortive Inter-complex Reduction. Chem. Eur. J. 2012, 18, 3955.
  16. Huang, J. J.-H.; Larsen, R. W.; Chan, S. I. The Interplay of Turn Formation and Hydrophobic Interactions on the Early Kinetic Events in Protein Folding. Chem. Comm. (Feature Article), (Royal Society of Chemistry) 2012, 48, 487.
  17. Chan, S. I. Proton Pumping in Cytochrome c Oxidase: The Coupling between Proton and Electron Gating. Proc. Nat. Acad. Sci. USA 2010, 107, 8505.
  18. Chan, S. I. A Physical Chemist's Expedition to Explore the World of Membrane Proteins. Annual Review of Biophysics 2009, 38, 1.

Update: 2019-01-23

期刊論文
  1. Brett K.‐Y. Chu, Ruei‐Fong Tsai, Chien‐Lun Hung, Yun‐Hsuan Kuo, Eric H.‐L. Chen, Yun‐Wei Chiang*, Sunney I. Chan*, Rita P.‐Y. Chen* Location of the cross‐β structure in prion fibrils: A search by seeding and electron spin resonance spectroscopy. Protein Science 2022-06, 31(6).
  2. Yi-Fang Tsai, Thiyagarajan Natarajan, Zhi-Han Lin, I-Kuen Tsai, Damodar Janmanchi, Sunney I. Chan*, Steve S.-F. Yu* Voltage-Gated Electrocatalysis of Efficient and Selective Methane Oxidation by Tricopper Clusters under Ambient Conditions. Journal of the American Chemical Society 2022-05-27, doi.org/10.1021/jacs.2c01169.
  3. Sunney I. Chan*, Vincent C.‐C. Wang, Peter P.‐Y. Chen, Steve S.‐F. Yu* Methane oxidation by the copper methane monooxygenase: Before and after the cryogenic electron microscopy structure of particulate methane monooxygenase from <i>Methylococcus capsulatus</i> (Bath). Journal of the Chinese Chemical Society 2022-05-23,  1-12.
  4. W.-H. Chang, H.-H. Lin, I-K. Tsai, S.-H. Huang, S.-C. Chung, I-P. Tu, S. S.-F. Yu, S. I. Chan Copper Centers in the Cryo-EM Structure of Particulate Methane Monooxygenase Reveal the Catalytic Machinery of Methane Oxidation. Journal of the American Chemical Society 2021143(26), 9922-9932.
  5. Sunney I. Chan, Phimonphan Chuankhayan, Pavan Kumar Reddy Nareddy, I-Kuen Tsai, Yi-Fang Tsai, Kelvin H.-C. Chen, Steve S.-F. Yu, Chun-Jung Chen Mechanism of Pyrroloquinoline Quinone-Dependent Hydride Transfer Chemistry from Spectroscopic and High-Resolution X-ray Structural Studies of the Methanol Dehydrogenase from Methylococcus capsulatus (Bath). Journal of the American Chemical Society 2021143(9), 3359-3372.
  6. Chen Yu‐Hsuan, Wu Chang‐Quan, Sung Pei‐Hua, Chan Sunney I.*, Chen Peter Ping‐Yu Turnover of a Methane Oxidation Tricopper Cluster Catalyst: Implications for the Mechanism of the Particulate Methane Monooxygenase (pMMO). ChemCatChem 2020-06-0512(11), 3088-3096.
  7. Chan Sunney I.*, Yu Steve S.-F., Liu Chih-Cheng, Mou Chung-Yuan Selective oxidation of light alkanes under mild conditions. Current Opinion in Green and Sustainable Chemistry 2020-0422, 39-46.
  8. Liu Chih-Cheng, Chou Hao-Ju, Lin Chan-Yi, Janmanchi Damodar, Chung Po-Wen, Mou Chung-Yuan, Yu Steve S.-F., Chan Sunney I.* The oversolubility of methane gas in nano-confined water in nanoporous silica materials. Microporous and Mesoporous Materials 2020-02293, 109793.
  9. Guan Hong-Hsiang,Hsieh Yin-Cheng, Lin Pei-Ju, Huang Yen-Chieh, Yoshimura Masato, Chen Li-Ying, Chen Shao-Kang, Chuankhayan Phimonphan, Lin Chien-Chih, Chen Nai-Chi, Nakagawa Atsuhi, Chan Sunney I., and Chen Chun-Jung* Structural insights into the electron/proton transfer pathways in the quinol:fumarate reductase from Desulfovibrio gigas. SCIENTIFIC REPORTS 2018-10-088, 14935.
  10. Yeh Chen-Hao, Yu Steve S.-F., Chan Sunney I., and Jyh Chiang Jiang* Quantum Chemical Studies of Methane Oxidation to Methanol on a Biomimetic Tricopper Complex: Mechanistic Insights. Chemistry Select 2018-05-143(18), 5113-5122.
  11. Liu Chih-Cheng, Janmanchi Damodar, Wen Da-Ren, Oung Jung-Nan, Mou Chung-Yuan, Yu Steve S.-F., Chan Sunney I.* Catalytic oxidation of light alkanes mediated at room temperature by a tricopper cluster complex immobilized in mesoporous silica nanoparticles. ACS SUSTAINABLE CHEMISTRY &amp; ENGINEERING 2018-03-136 (4), 5431&ndash;5440.
  12. Thiyagarajan Natarajan, Janmanchi Damodar, Tsai Yi-Fang, Wanna Wondemagegn Hailemichael, Ramu Ravirala, Chan Sunney I.*, Zen Jyh-Myng*, Yu Steve S.-F.* A carbon electrode functionalized by a tricopper cluster complex: Overcoming overpotential and production of hydrogen peroxide in the oxygen reduction reaction. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2018-02-0257(14), 3612-3616.
  13. Wang Vincent C.-C., Maji Suman, Chen Peter P.-Y., Lee Hung Kay, Yu Steve S.-F., Chan Sunney I. Alkane Oxidation: Methane Monooxygenases, Related Enzymes, and Their Biomimetics. Chemical Reviews 2017117(13), 8574-8621.
  14. Liu Chih-Cheng, Ramu Ravirala, Chan Sunney I., Mou Chung-Yuan, Yu Steve S.-F. Chemistry in confined space: a strategy for selective oxidation of hydrocarbons with high catalytic efficiencies and conversion yields under ambient conditions. Catalysis Science & Technology 20166(20), 7623-7630.
  15. Liu Chih-Cheng, Mou Chung-Yuan, Yu Steve S.-F., Chan Sunney I. Heterogeneous formulation of the tricopper complex for efficient catalytic conversion of methane into methanol at ambient temperature and pressure. Energy & Environmental Science 20169(4), 1361-1374.
  16. Chen Kelvin H.-C., Chuankhayan Phimonphan, Wu Hsin-Hui, Chen Chun-Jung, Fukuda Mitsuhiro, Yu Steve S.-F., Chan Sunney I. The bacteriohemerythrin from Methylococcus capsulatus (Bath): Crystal structures reveal that Leu114 regulates a water tunnel. Journal of Inorganic Biochemistry 2015150, 81-89.
  17. Pham Minh D., Lin Ya-Ping, Van Vuong Quan, Nagababu Penumaka, Chang Brian T.-A., Ng Kok Yaoh, Chen Chein-Hung, Han Chau-Chung, Chen Chung-Hsuan, Li Mai Suan, Yu Steve S.-F., Chan Sunney I. Inactivation of the particulate methane monooxygenase (pMMO) in Methylococcus capsulatus (Bath) by acetylene. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 20151854(12), 1842-1852.
  18. Chen Nai-Chi, Yoshimura Masato, Guan Hong-Hsiang, Wang Ting-Yu, Misumi Yuko, Lin Chien-Chih, Chuankhayan Phimonphan, Nakagawa Atsushi, Chan Sunney I., Tsukihara Tomitake, Chen Tzong-Yueh, Chen Chun-Jung Crystal Structures of a Piscine Betanodavirus: Mechanisms of Capsid Assembly and Viral Infection. PLOS Pathogens 201511(10), e1005203.
  19. Lin Nai-Ti, Satyanarayana Kamani, Chen Chih-Hsien, Tsai Yi-Fang, Yu Steve Sheng-Fa, Chan Sunney I., Luh Tien-Yau Controlling the Orientation of Pendants in Two-Dimensional Comb-Like Polymers by Varying Stiffness of Polymeric Backbones. Macromolecules 201447(18), 6166-6172.
  20. Liu Chih-Cheng, Lin Tien-Sung, Chan Sunney I., Mou Chung-Yuan A room temperature catalyst for toluene aliphatic C–H bond oxidation: Tripodal tridentate copper complex immobilized in mesoporous silica. Journal of Catalysis 2014322, 139-151.
  21. Chen Yao-Sheng, Luo Wen-I, Yang Chung-Ling, Tu Yi-Jung, Chang Chun-Wei, Chiang Chih-Hsiang, Chang Chi-Yao, Chan Sunney I., Yu Steve S.-F. Controlled oxidation of aliphatic CH bonds in metallo-monooxygenases: Mechanistic insights derived from studies on deuterated and fluorinated hydrocarbons. Journal of Inorganic Biochemistry 2014134, 118-133.
  22. Nagababu Penumaka, Yu Steve S.-F., Maji Suman, Ramu Ravirala, Chan Sunney I. Developing an efficient catalyst for controlled oxidation of small alkanes under ambient conditions. Catal. Sci. Technol. 20134(4), 930-935.
  23. Chen Peter P.-Y., Nagababu Penumaka, Yu Steve S.-F., Chan Sunney I. Development of the Tricopper Cluster as a Catalyst for the Efficient Conversion of Methane into MeOH. ChemCatChem 20136(2), 429-437.
  24. Liu IPC, Chen PPY, Chan SI Models for the trinuclear copper(II) cluster in the particulate methane monooxygenase from methanotrophic bacteria: Synthesis, spectroscopic and theoretical characterization of trinuclear copper(II) complexes. Comptes Rendus Chimie 2012-0315, 214-224.
  25. Lo FC, Lee JF, Liaw WF, Hsu IJ, Tsai YF, Chan SI, Yu SS The metal core structures in the recombinant Escherichia coli transcriptional factor SoxR. CHEMISTRY-A EUROPEAN JOURNAL 2012-01, 18(9)2665-2577.
  26. Lin KF, Sun CS, Huang YC, Chan SI, Koubek J, Wu TH, Huang JJ Cotranslational protein folding within the ribosome tunnel influences trigger-factor recruitment.. Biophysical journal 2012102(12), 2818-27.
  27. Huang JJ, Larsen RW, Chan SI The interplay of turn formation and hydrophobic interactions on the early kinetic events in protein folding.. Chemical communications 201248(4), 487-497.
  28. Chen KH, Wu HH, Ke SF, Rao YT, Tu CM, Chen YP, Kuei KH, Chen YS, Wang VC, Kao WC, Chan SI Bacteriohemerythrin bolsters the activity of the particulate methane monooxygenase (pMMO) in Methylococcus capsulatus (Bath).. Journal of inorganic biochemistry 2012111, 10-7.
  29. Maji S, Lee JC, Lu YJ, Chen CL, Hung MC, Chen PP, Yu SS, Chan SI Dioxygen activation of a trinuclear Cu(I)Cu(I)Cu(I) cluster capable of mediating facile oxidation of organic substrates: competition between O-atom transfer and abortive intercomplex reduction.. Chemistry (Weinheim an der Bergstrasse, Germany) 201218(13), 3955-68.
  30. Jou-Yin Fang, Yuan-Lan Chiang, Yin-Cheng Hsieh, Vincent C.-C. Wang, Yen-Chieh Huang, Phimonphan Chuankhayan, Ming-Chi Yang, Ming-Yih Liu, Sunney I. Chan, and Chun-Jung Chen Crystallization of Adenylylsulfate Reductase from Desulfovibrio gigas: A Strategy Based on Controlled Protein Oligomerization. CRYSTAL GROWTH & DESIGN 2011-0411, 2127-2134.
  31. Pei-Fen Su, Chin-Jin Li, Chih-Chien Hsu, Spencer Benson, Sheng-Yang Wang, Kandan Aravindaram, Sunney I. Chan, Shih-Hsiung Wu, Feng-Ling Yang, Wen-Ching Huang, Lie-Fen Shyur, and Ning-Sun Yang Dioscorea Phytocompounds Enhance Murine Splenocyte Proliferation Ex Vivo and Improve Regeneration of Bone Marrow Cells In Vivo. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2011, 1-11.
  32. Wu LL, Yang CL, Lo FC, Chiang CH, Chang CW, Ng KY, Chou HH, Hung HY, Chan SI, Yu SS Tuning the regio- and stereoselectivity of C-H activation in n-octanes by cytochrome P450 BM-3 with fluorine substituents: evidence for interactions between a C-F bond and aromatic pi systems.. Chemistry - A European Journal 201117(17), 4774-4787.
  33. Chan SI, Nguyen HH, Chen KH, Yu SS Overexpression and purification of the particulate methane monooxygenase from Methylococcus capsulatus (Bath).. Methods in enzymology 2011495, 177-193.
  34. Chan SI Proton pumping in cytochrome c oxidase: the coupling between proton and electron gating.. Proceedings of the National Academy of Sciences of the United States of America 2010107(19), 8505-8506.
  35. Lee MM, Isaza CE, White JD, Chen RP, Liang GF, He HT, Chan SI, Chan MK Insight into the substrate length restriction of M32 carboxypeptidases: characterization of two distinct subfamilies.. Proteins 200977(3), 647-657.
  36. Chan SI A physical chemist's expedition to explore the world of membrane proteins.. Annual review of biophysics 200938, 1-27.
  37. Chen HL, Huang YF, Lim TS, Su CH, Chen PH, Su AC, Wong KT, Chao TC, Chan SI, Fann W Excited-state backbone twisting of polyfluorene as detected from photothermal after-effects.. JOURNAL OF PHYSICAL CHEMISTRY B 2009113(25), 8527-31.
  38. Ho CC, Lee LY, Huang KT, Lin CC, Ku MY, Yang CC, Chan SI, Hsu RL, Chen RP Tuning the conformational properties of the prion peptide.. Proteins 200976(1), 213-225.
  39. Isaza CE, Zhong X, Rosas LE, White JD, Chen RP, Liang GF, Chan SI, Satoskar AR, Chan MK A proposed role for Leishmania major carboxypeptidase in peptide catabolism.. Biochemical and biophysical research communications 2008373(1), 25-29.
  40. Chan SI, Yu SS Controlled oxidation of hydrocarbons by the membrane-bound methane monooxygenase: the case for a tricopper cluster.. Accounts of chemical research 200841(8), 969-979.
  41. Kao WC, Wang VC, Huang YC, Yu SS, Chang TC, Chan SI Isolation, purification and characterization of hemerythrin from Methylococcus capsulatus (Bath).. Journal of inorganic biochemistry 2008102(8), 1607-1614.
  42. Ng KY, Tu LC, Wang YS, Chan SI, Yu SS Probing the hydrophobic pocket of the active site in the particulate methane monooxygenase (pMMO) from Methylococcus capsulatus (Bath) by variable stereoselective alkane hydroxylation and olefin epoxidation.. Chembiochem : a European journal of chemical biology 20089(7), 1116-1123.
  43. Chen PP, Yang RB, Lee JC, Chan SI Facile O-atom insertion into C-C and C-H bonds by a trinuclear copper complex designed to harness a singlet oxene.. Proceedings of the National Academy of Sciences of the United States of America 2007104(37), 14570-14575.
  44. Chen SH, Liao HK, Chang CY, Juo CG, Chen JH, Chan SI, Chen YJ Targeted protein quantitation and profiling using PVDF affinity probe and MALDI-TOF MS.. Proteomics 20077(17), 3038-3050.
  45. Yu SS, Ji CZ, Wu YP, Lee TL, Lai CH, Lin SC, Yang ZL, Wang VC, Chen KH, Chan SI The C-terminal aqueous-exposed domain of the 45 kDa subunit of the particulate methane monooxygenase in Methylococcus capsulatus (Bath) is a Cu(I) sponge.. Biochemistry 200746(48), 13762-74.
  46. Liang, FC, Chen, RPY, Lin, CC, Huang, KT and Chan, SI Tuning the conformation properties of a peptide by glycosylation and phosphorylation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2006342(2), 482-488.
  47. Tseng, CF, Burger, A, Mislin, GLA, Schalk, IJ, Yu, SSF, Chan, SI and Abdallah, MA Bacterial siderophores: the solution stoichiometry and coordination of the Fe(III) complexes of pyochelin and related compounds. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 200611(4), 419-432.
  48. Chen, PPY and Chan, SI Theoretical modeling of the hydroxylation of methane as mediated by the particulate methane monooxygenase. JOURNAL OF INORGANIC BIOCHEMISTRY 2006100(4), 801-809.
  49. S.I. Chan*, J.J.-T. Huang, R.W. Larsen, R.S. Rock and K.C. Hansen “Early Kinetics Events in Protein Folding: The Development and Applications of Caged Peptides” in Dynamic Studies in Biology. Phototriggers, Photoswitches, and Caged Biomolecules. Goeldner, M. and Givens. R. (eds), Wiley-VCH GmbH & Co. (Germany).  2005, 479-494.
  50. N.N.-W. Kuo, J. Huang, J. Miksovska, P.-Y. Chen, R. Larsen and S.I. Chan* Effects of turn stability on the kinetics of refolding of a hairpin in β-sheet.. J. Am. Chem. Soc. 2005127(48), 16945-16954.
  51. Y.Y. Chen, S.Y. Luo, S.C. Hung, S.I. Chan* and D.L. Tzou 13C solid-state NMR chemical shift anisotropy analysis of the anomeric carbon in carbohydrates.. Carbohydr Res. 2005340(4), 723-729.
  52. Chen RP, Huang JJ, Chen HL, Jan H, Velusamy M, Lee CT, Fann W, Larsen RW, Chan SI Measuring the refolding of beta-sheets with different turn sequences on a nanosecond time scale.. Proceedings of the National Academy of Sciences of the United States of America 2004101(19), 7305-10.
  53. S.I. Chan*, K.H.C. Chen, S.S.F. Yu, C.L. Chen and S.S.J. Kuo Toward delineating the structure and function of the particulate methane monooxygenase from methanotrophic bacteria.. Biochemistry 200443, 4421-4430.
  54. R.S. Rock, K.C. Hansen, R.W. Larsen and S.I. Chan* Rapid photochemical triggering of protein unfolding in a nondenaturing environment.. J. Chem. Phys. 2004307, 201-208.
  55. M.S. Vinchurkar, K.H.C. Chen, S.S.F. Yu, S.J. Kuo, H.C. Chiu, S.H. Chien and S.I. Chan* Polarized ATR-FTIR spectroscopy of the membrane-embedded domains of the particulate methane monooxygenase.. Biochemistry 200443, 13283-13292.
  56. W.C. Kao, Y.R. Chen, E.C. Yi, H. Lee, Q. Tian, K.M. Wu, S.F. Tsai, S.S.F. Yu, Y.J. Chen, R. Aebersold and S.I. Chan* Quantitative proteomic analysis of metabolic regulation by copper ions in Methylococcus capulatus (Bath).. J. Biol. Chem. 2004279, 51554-51560.
  57. C.L. Chen, K.H.C. Chen, S.C. Ke, S.S.F. Yu and S.I. Chan* Preparation and characterization of a (Cu, Zn)-pMMO from Methylococcus capsulatus (Bath).. J. Inorg. Biochem. 200498, 2125-2130.
  58. Pavlova SV, Chen KH, Chan SI Spectroscopic characterization of the oxo-transfer reaction from a bis(mu-oxo)dicopper(III) complex to triphenylphosphine.. Dalton transactions (Cambridge, England : 2003) 2004(20), 3261-72.
  59. S.S.F. Yu, L.Y. Wu, K.H.C. Chen, W.I. Luo, D.S. Huang and S.I. Chan* The stereospecific hydroxylation of [2,2-2h2]butane and chiral dideuteriobutanes by the particulate methane monooxygenase from Methylococcus capsulatus (Bath).. J. Biol. Chem. 2003278, 40658-40669.
  60. S.S.F. Yu, L.Y. Wu, K.H.C. Chen, M.Y.H. Tseng, Y.S. Wang, C.F. Tseng, Y.J. Chen, D.S. Huang and S.I. Chan* Production of high quality pMMO in high yields from Methylococcus capsulatus (Bath) with a hollow-fiber membrane bioreactor.. J. Bacteriol. 2003185, 5915-5924.
專利
  • 可催化碳氫化合物氧化之分子催化劑與氧化碳氫化合物的方法 Molecular Catalyst Capable of Catalyzing Oxidation of Hydrocarbons and Methods for Oxidizing Hydrocarbons
    USA-regular:10,005,746 2018
  • 可催化碳氫化合物氧化之分子催化劑與氧化碳氫化合物的方法 Molecular Catalyst Capable of Catalyzing Oxidation of Hydrocarbons and Methods for Oxidizing Hydrocarbons
    Taiwan:I625164 2018