中央研究院化學研究所

本實驗室之研究重點為多並苯類化合物之合成與其在材料科學上之應用。我們最近開發出了兩個十分有用的合成反應用於建構多並苯類結構。我們也合成出了一系列帶有多並苯類化結構單元的硫醇分子，將應用於含多並苯類化合物之自組裝單層薄膜。
在多並苯類化合物上之(醚-醚)及(醚-硫醚)交換反應
以重複加長法合成多並苯類化合物各類用於建構自組裝單層薄膜的多並苯類化合物硫醇分子

1. Lin, K.-H.; Pal, B.; Tsou, L.-D.; Lin, C.-H. Iterative Synthesis of Acene via Homo-elongation. Chem. Comm. 2009, 803.
2. Chen, J.-C.; Lee, T.-S.; Lin, C.-H. Syntheses of Ladder-Type Oligonaphthalene Derivatives and Their Photophysical and Electrochemical Properties. Chem. Eur. J. 2008, 14, 2777.
3. Tseng, Y. P.; Kuo, Y. H.; Hu, C. P.; Jeng, K. S.; D. Janmanchi, D.; Lin, C. H.; Chou, C. K.; Yeh, S. F. The Role of Helioxanthin in Inhibiting Human Hepatitis B Viral Replication and Gene Expression by Interfering with the Host Transcrioptional Machinery. Antiviral Res. 2008, 77, 206.
4. Tseng, P.-C.; Hsu, H.-C.; Janmanchi, D.; Lin, C.-H.; Kuo, Y.-H.; Chou, C.-K.; Yeh, S.-F. The Role of Helioxanthin in Inhibiting Interleukin-1β-induced MIP-1β Production in Human Hepatoma Cells by Reduction of c-Jun Expression and Subsequent Binding of the c-jun/CREB1 Complex to the AP-1/CRE Site of the MIP-1β Promoter. Biochem. Pharma. 2008, 76, 1121.
5. Lin, Y. C.; Lin, C. H. Synthesis of tetracene sulfoxide and tetracene sulfone via a cascade cyclization reaction. Org. Lett. 2007, 9, 2075.
6. Yang, H.-C.; Lin, S.-M.; Liu, Y.-H.; Wang, Y.; Chen, M.-M.; Sheu, H.-S.; Tsou, D.-L.; Lin, C-H.; Luh, T.-Y. Ring Opening Metathesis Polymerization of Bisnorbornene Derivatives Linked by Cp2Ni2(m-S)2 Bridge. J. Organometallic Chem. 2006, 691, 3196.
7. Radhakrishnan K; Lin, C-H. Synthesis of anthryl sulfides from anthryl methyl ethers via acid-catalyzed ether-sulfide exchange reaction. Synlett 2005, 14, 2179
8. Lin, C-H.; Radhakrishnan K. Synthesis of anthracene ethers from anthracene methyl ethers via an acid-catalyzed exchange reaction. Chem. Comm. 2005, 4, 504
9. Lin, C-H.; Tour, J. Hydrogen-Bond-Assisted p-Stacking of Shape-Persistent Cyclophanes. J. Org. Chem. 2002, 67, 7761.

Update： 2019-08-27

1. Ting-Yu Li, Yi-Chun Lin, Yu-Huei Song, Hsiu-Feng Lu, Ito Chao*, Chih-Hsiu Lin* Synthesis and Physical Study of Perylene and Anthracene Polynitrile as Electron Acceptors. Organic Letters 2019-07-19, 21(14) 5397-5401.
2. Jhih-Liang Huang, BillaBhargava Rao, Manyam Praveen Kumar, Hsiu-Feng Lu, Ito Chao*, Chih-Hsiu Lin* Dicyclopenta[ghi,pqr]perylene as a Structural Motif for Bowl-Shaped Hydrocarbons: Synthetic and Conformational Studies. Organic Letters 2019-04-19, 21(8) 2504-2508.
3. Bikash Pal, Chun-Hsiung Chang, Cian-Jhe Zeng, Chih-Hsiu Lin* Template-Assisted Benzannulation Route to Pentacene and Tetracene Derivatives and its Application to Construct Amphiphilic Acenes That Self-Assemble into Helical Wires. Chemistry - A European Journal 2017-12-01, 23(69) 17542-17548.
4. Bikash Pal, Bo-Chao Lin, Mark Vincent Carreon dela Cerna, Chao-Ping Hsu*, Chih-Hsiu Lin* Face-to-Face Packing of 2,3,9,10-Tetrasubstituted Pentacene Derivatives Revealed through a Solid State [4 + 4] Thermal Cycloaddition and Molecular Dynamic Simulation. The Journal of Organic Chemistry 2016-08-05, 81(15) 6223-6234.
5. Chih-Hsiu Lin, Gregory S. Ferguson, Manoj K. Chaudhury* Electrokinetics of polar liquids in contact with nonpolar surfaces.. Langmuir : the ACS journal of surfaces and colloids 2013-06-25, 29(25), 7793-801.
6. Damodar Janmanchi, Chih Hsiu Lin*, Jui-yu Hsieh, Ya-ping Tseng, Tai-an Chen, Hong-jhih Jhuang, Sheau Farm Yeh* Synthesis and biological evaluation of helioxanthin analogues. Bioorganic & Medicinal Chemistry 2013-04-01, 21, 2163-2176.
7. Billa Bhargava Rao , Jun-Ru Wei , and Chih-Hsiu Lin, New Synthetic Routes to Z-Shape Functionalized Perylenes. ORGANIC LETTERS 2012-06, 14, 3640-3643.
8. Yi-Chun Lin , Chih-Hsiu Lin , Chan-Yu Chen , Shih-Sheng Sun and Bikash Pal Synthesis of electron deficient acene derivatives via a bidirectional iterative elongation reaction. ORGANIC & BIOMOLECULAR CHEMISTRY 2011-04, 9,4507-4517.
9. Damodar Janmanchi, Ya Ping Tseng, Kuei-Chen Wang, Ray Ling Huang, Chih Hsiu Lin, Sheau Farn Yeh Synthesis and the biological evaluation of arylnaphthalene lignans as anti-hepatitis B virus agents. BIOORGANIC & MEDICINAL CHEMISTRY 2010-02, 18,1213-1266.
10. Chih-hsiu Lin, Tong-Tsou Hsu Synthesis of Benzo[c] and Naphtho[c]heterocycle Diesters and Dinitriles via Homoelongation. JOURNAL OF ORGANIC CHEMISTRY 2009-11, 74 (23), 9180-9187.
11. Ke-Han Lin, Bikash Pal, Li-Der Tsou, Chih-Hsiu Lin* Iterative synthesis of acenes via homo-elongation . Chem.Comm. 2009-02, 803-805.
12. Pei-Chi Tseng, Hsing-Chih Hsu, Damodar Janmanchi, Chih-Hsiu Lin, Yueh-Hsiung Kuo, Chen-Kung Chou* Sheau-Farn Yeh* The Role of Helioxanthin in Inhibiting Interleukin-1β-induced MIP-1β Production in Human Hepatoma Cells by Reduction of c-Jun Expression and Subsequent Binding of the c-jun/CREB1 Complex to the AP-1/CRE Site of the MIP-1β Promoter. Biochem. Pharma. 2008-10, 76, 1121-1133.
13. Y. P. Tseng, Y. H. Kuo, C. P. Hu, K. S. Jeng, D. Janmanchi, C. H. Lin, C. K. Chou* S. F. Yeh* The role of helioxanthin in inhibiting human hepatitis B viral replication and gene expression by interfering with the host transcrioptional machinery . Antiviral Res. 2008-05, 77, 206-214.
14. Jun-Chun Chen, Tsi-Shi Lee, Chih-Hsiu Lin* Syntheses of Ladder-Type Oligonaphthalene Derivatives and Their Photophysical and Electrochemical Properties. CHEMISTRY-A EUROPEAN JOURNAL 2008-02, 14, 2777-2787.
15. Yi-Chun Lin, Chih-Hsiu Lin* Synthesis of tetracene sulfoxide and tetracene sulfone via a cascade cyclization reaction. Org. Lett. 2007-04, 9, 2075-2078.
16. Yang, HC, Lin, SM, Liu, H, Wang, Y, Chen, MM, Sheu, HS, Tsou, DL, Lin, CH and Luh, TY Ring opening metathesis polymerization of bisnorbornene derivatives linked by Cp2Ni2(mu-S)(2) bridge. JOURNAL OF ORGANOMETALLIC CHEMISTRY 2006-07, 691(14), 3196-3200.
17. C-H Lin* and K. Radhakrishnan Synthesis of anthracene ethers from anthracene methyl ethers via an acid-catalyzed exchange reaction.. Chem. Comm. 2005, 4, 504-506.
18. K. Radhakrishnan and C.-H. Lin* Synthesis of anthryl sulfides from anthryl methyl ethers via acid-catalyzed ether-sulfide exchange reaction.. Synlett 2005, 14, 2179-2182.