Institute of Chemistry, Academia Sinica

Our research interests are primarily in the areas of organic synthesis and chemical biology. We are interested in using chemistry as tools to study and address in biology. The foremost focus centers on the developing novel chemical bioconjugations and related fluorescent smart probes for selective labeling of biomolecules in cells to understand cellular processes. In the field of organic synthesis, the Shie lab at IoC focuses on development new synthetic methodologies for the efficient and economical synthesis of biomedical significance glycoconjugates and carbohydrate-based small molecular inhibitors against infection diseases.

~ Antiviral and antibacterial drug discovery.
~ Fluorescence-forming probes and chemosensors upon chemical bioconjugation.
~ Development of novel chemical bioconjugation reactions in biological systems.
~ Fluorescent labeling chemistry of biomolecule in cell.

1. Shie, J.-J.; Liu, Y.-C.; Hsiao, J.-C.; Fang, J.-M.; Wong, C.-H. A cell-permeable and triazole-forming fluorescence probe for glycoconjugate imaging in live cells. Chem. Commun. 2017, 53, 1490.
2. Shie, J.-J.; Liu, Y.-C.; Lee, Y.-M.; Lim, C.; Fang, J.-M.; Wong, C.-H. An azido-BODIPY probe for glycosylation: initiation of strong fluorescence upon triazole formation. J. Am. Chem. Soc. 2014, 136, 9953.
3. Cheng, C.-K.; Tsai, C.-H.; Shie, J.-J.; Fang, J.-M. From neuraminidase inhibitors to conjugates: a step towards better anti-influenza drugs? Future Med. Chem. 2014, 6, 757. (Review)
4. Shie, J.-J.; Fang, J.-M. Phosphonate congeners of oseltamivir and zanamivir as effective anti-influenza drugs: design, synthesis and biological activity. J. Chin. Chem. Soc. 2014, 61, 127. (Review)
5. Shie, J.-J.; Fang, J.-M.; Lai, P.-T.; Wen, W.-H.; Wang, S.-Y.; Cheng, Y.-S. E.; Tsai, K.-C.; Yang, A.-S.; Wong, C.-H. A practical synthesis of zanamivir phosphonate congeners with potent anti-influenza activity. J. Am. Chem. Soc. 2011, 133, 17959.
6. Shie, J.-J.; Chen, C.-A.; Lin, C.-C.; Ku, A. F.; Cheng, T.-J. R.; Fang, J.-M.; Wong, C.-H. Regioselective synthesis of di-C-glycosylflavones possessing anti-inflammation activities. Org. Biomol. Chem. 2010, 8, 4451.
7. Shie, J.-J.; Fang, J.-M. The development of anti-influenza drugs: Rational structural-design neuraminidase inhibitors. Chemistry 2008, 66, 279. (Review in Chinese)
8. Kuo, C.-J.; Shie, J.-J.; Fang, J.-M.; Yen, G.-R.; Hsu, J. T.-A.; Liu, H.-G.; Tseng, S.-N.; Chang, S.-C.; Lee, C.-Y.; Shih, S.-R.; Liang, P.-H. Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents. Bioorg. Med. Chem. 2008, 16, 7388.
9. Shie, J.-J.; Fang, J.-M.; Wong, C.-H. A concise and flexible synthesis of the potent anti-influenza agents tamiflu and tamiphosphor. Angew. Chem. 2008, 120, 5872‒5875; Angew. Chem. Int. Ed. 2008, 47, 5788.
10. Shie, J.-J.; Fang, J.-M.; Wang, S.-Y.; Tsai, K.-C.; Cheng, Y.-S. E.; Yang, A.-S.; Hsiao, S.-C.; Su, C.-Y.; Wong, C.-H. Synthesis of tamiflu and its phosphonate congeners possessing potent anti-influenza activity. J. Am. Chem. Soc. 2007, 129, 11892.
11. Shie, J.-J.; Fang, J.-M. Microwave-assisted one-pot tandem reactions for direct conversion of primary alcohols and aldehydes to triazines and tetrazoles in aqueous media. J. Org. Chem. 2007, 72, 3141.
12. Shie, J.-J.; Fang, J.-M.; Kuo, T.-H.; Kuo, C.-J.; Liang, P.-H.; Huang, H.-J.; Wu, Y.-T.; Jan, J.-T.; Cheng, Y.-S. E.; Wong, C.-H. Inhibition of the severe acute respiratory syndrome 3CL protease by peptide- mimetic α,β-unsaturated esters. Bioorg. Med. Chem. 2005, 13, 5240.
13. Shie, J.-J.; Fang, J.-M.; Kuo, C.-J.; Kuo, T.-H.; Liang, P.-H.; Huang, H.-J.; Yang, W.-B.; Lin, C.-H.; Chen, J.-L.; Wu, Y.-T.; Wong, C.-H. Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease. J. Med. Chem. 2005, 48, 4469.
14. Shie, J.-J.; Workman, P. S.; Evans, W. J.; Fang, J.-M. Comparative study of TmI₂, SmI₂, and SmI₂/HMPA in the cross-coupling reactions of 2-acetylthiophene and thiophene-2-carboxylate with carbonyl compounds. Tetrahedron Lett. 2004, 45, 2703.
15. Shie, J.-J.; Fang, J.-M. Direct conversion of aldehydes to amides, tetrazoles, and triazines in aqueous media by one-pot tandem reactions. J. Org. Chem. 2003, 68, 1158.
16. Yang, S.-M.; Shie, J.-J.; Fang, J.-M.; Nandy, S. K.; Chang, H.-Y.; Lu, S.-H.; Wang, G. Synthesis of polysubstituted benzothiophenes and sulfur containing polycyclic aromatic compounds via samarium diiodide promoted three-component coupling reactions of thiophene-2-carboxylate. J. Org. Chem. 2002, 67, 5208.
17. Shie, J.-J.; Yang, S.-M.; Chen, C.-T.; Fang, J.-M. A novel photochromic system of 4,5-dialkenylthiophenes constructed by the samarium diiodide promoted coupling reactions of thiophene-2-carboxylate with aryl ketones. Org. Lett. 2002, 4, 1099.

Selected Patents:
1. Wong, C.-H.; Fang, J.-M.; Shie, J.-J. “Reactive labelling compounds and their uses thereof.” US Patent Application Publication (2015). Pub. No.: US 2015/0309041 A1.
2. Wong, C.-H.; Fang, J.-M.; Shie, J.-J. “Benzocyclooctyne compounds and their uses thereof.” US Patent Application Publication (2015). Pub. No.: US 2015/0241439 A1.
3. Wong, C.-H.; Fang, J.-M.; Cheng, Y.-S.; Shie, J.-J. “Zanamivir phosphonate congeners with anti-influenza activity and determining oseltamivir susceptibility of influenza viruses.” US Patent No. 9403855 (2016).
4. Wong, C.-H.; Fang, J.-M.; Shie, J.-J.; Cheng, Y.-S. E.; Jan, J.-T. “Synthesis of oseltamivir containing phosphonate congeners with anti-influenza activity.” US Patent No. US 7888337 (2011).

Update： 2023-11-07

1. Shwee Khuan Leong, Yi-Ju Chen, Jye-Chian Hsiao, Chun-Yi Tsai, Jiun-Jie Shie* Site-Specific and Multiple Fluorogenic Metabolic Glycan Labeling and Glycoproteomic Profiling in Live Cells. CHEMBIOCHEM 2023-07-25, 24, e202300522.
2. Ching-Han Lee, Yi-Yun Lee, Yu-Chu Chang, Wen-Li Pon, Sue-Ping Lee, Niaz Wali, Takehito Nakazawa, Yoichi Honda, Jiun-Jie Shie, Yen-Ping Hsueh* A Carnivorous Mushroom Paralyzes and Kills Nematodes via a Volatile Ketone. SCIENCE ADVANCES 2023-01-18, 9, eade4809.
3. Viktoryia Kolas, Jose Sandino A. Bandonil, Niaz Wali, Kuo‑Chiang Hsia, Jiun‑Jie Shie*, Bon‑chu Chung* A Synthetic Pregnenolone Analog Promotes Microtubule Dynamics and Neural Development. CELL AND BIOSCIENCE 2022-12-01, 12, 190.
4. Jing Li, Shih-Yi Hsiung, Mu-Rong Kao, Xiaohui Xing, Shu-Chieh Chang, Damao Wang, Pei-Yun Hsieh, Pi-Hui Liang, Zaibiao Zhu, Ting-Jen Rachel Cheng, Jiun-Jie Shie, Jing-Ping Liou, D. Wade Abbott, Sung Won Kwon, Yves S. Y. Hsieh* Structural Compositions and Biological Activities of Cell Wall Polysaccharides in the Rhizome, Stem, and Leaf of Polygonatum odoratum (Mill.) Druce. CARBOHYDRATE RESEARCH 2022-09-01, 521, 108662.
5. Shwee Khuan Leong, Jye-Chian Hsiao, Jiun-Jie Shie* A Multiscale Molecular Dynamic Analysis Reveals the Effect of Sialylation on EGFR Clustering in a CRISPR/Cas9-Derived Model. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022-08-06, 23, 8754.
6. Cheng-Ting Shih, Bo-Hong Kuo, Chun-Yi Tsai, Mei-Chun Tseng, Jiun-Jie Shie* Dibenzocyclooctendiones (DBCDOs): Arginine-Selective Chemical Labeling Reagents Obtained through Benzilic Acid Rearrangement. ORGANIC LETTERS 2022-06-21, 24, 4694-4698.
7. Tzu-Tang Wei, Mark Chandy, Masataka Nishiga, Angela Zhang, Kaavya Krishna Kumar, Dilip Thomas, Amit Manhas, Siyeon Rhee, Johanne Marie Justesen, Ian Y. Chen, Hung-Ta Wo, Saereh Khanamiri, Johnson Y. Yang, Frederick J. Seidl, Noah Z. Burns, Chun Liu, Nazish Sayed, Jiun-Jie Shie, Chih-Fan Yeh, Kai-Chien Yang, Edward Lau, Kara L. Lynch, Manuel Rivas, Brian K. Kobilka, Joseph C. Wu* Cannabinoid Receptor 1 Antagonist Genistein Attenuates Marijuana-induced Vascular Inflammation. CELL 2022-05-12, 185, 1676-1693.
8. Chien-Chi Wu, Ram Ambre, Meng-Hsuan Lee, Jiun-Jie Shie* Flexible Construction Approach to the Synthesis of 1,5-Substituted Pyrrole-3-carbaldehydes from 5-Bromo-1,2,3-triazine. ORGANIC LETTERS 2022-04-06, 24, 2889-2893.
9. Kalyana Kumar Ponnapalli, Yi-Chi Ho, Mei-Chun Tseng, Bhanu Vijaya Sekhar Vasamsetti, Jiun-Jie Shie* One-Pot Glycosylation Strategy Assisted by Ion Mobility–Mass Spectrometry Analysis toward the Synthesis of N-Linked Oligosaccharides. JOURNAL OF ORGANIC CHEMISTRY 2022-04-04, 87, 5339-5357.
10. Pei-Hsuan Chou, Cong-Kai Luo, Niaz Wali, Wen-Yen Lin, Shang-Kok Ng, Chun-Hao Wang, Mingtao Zhao, Sheng-Wei Lin, Pei-Ming Yang, Pin-Jung Liu, Jiun-Jie Shie*, Tzu-Tang Wei* A Chemical Probe Inhibitor Targeting STAT1 Restricts Cancer Stem Cell Traits and Angiogenesis in Colorectal Cancer. JOURNAL OF BIOMEDICAL SCIENCE 2022-03-22, 29, 20.
11. Cheng-Hsin Ou Yang, Wan-Hsuan Liu, Sheng Yang, Yao-Yu Chiang, Jiun-Jie Shie* Copper-Mediated Synthesis of (E)-β-Aminoacrylonitriles from 1,2,3-Triazine and Secondary Amines. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2022-02-28, (12), e202200209.
12. Long-Zhi Lin, Sheng Yang, Wan-Hsuan Liu, Jiun-Jie Shie* Dichotomous Selectivity in Indium-Mediated Aza-Barbier-Type Allylation of 2-N-Acetyl Glycosyl Sulfinylimines in Brine: Convenient Access to Potent Anti-Influenza Agents. JOURNAL OF ORGANIC CHEMISTRY 2022-01-25, 87, 2324-2335.
13. Devi Wahyuningtyas, Wen-Hao Chen, Ruei-Yu He, Yung-An Huang, Chia-Kang Tsao, Yu-Jung He, Chu-Yi Yu, Po-Chao Lu, Yu-Cai Chen, Sheng-Hann Wang, Ka Chon Ng, Bryan Po-Wen Chen, Pei-Kuen Wei, Jiun-Jie Shie, Chun-Hong Kuo, Y. Henry Sun, and Joseph Jen-Tse Huang* Polyglutamine-Specific Gold Nanoparticle Complex Alleviates Mutant Huntingtin-Induced Toxicity. ACS APPLIED MATERIALS & INTERFACES 2021-12-16, 13, 60894-60906.
14. Danni Wu, Kathleen Joyce Carillo, Jiun-Jie Shie, Steve S.-F. Yu, Der-Lii M. Tzou* Resolving Entangled JH-H-Coupling Patterns for Steroidal Structure Determinations by NMR Spectroscopy. MOLECULES 2021-04-30, 26, 2643.
15. Tsung‐Shing Andrew Wang*, Ruo‐Yu Wu, Yu Hong, Zhe‐Chong Wang, Tsung‐Lin Li, Jiun‐Jie Shie, Cheng‐Chih Hsu Labeling and Characterization of Phenol‐Containing Glycopeptides Using Chemoselective Probes with Isotope Tags. ChemBioChem 2021-04-29, 22, 2415-2419.
16. Jing Li, Damao Wang, Shu-Chieh Chang, Pi-Hui Liang, Vaibhav Srivastava, Shih-Yun Guu, Jiun-Jie Shie, Kay-Hooi Khoo, Vincent Bulone, Yves S. Y. Hsieh* Production of Structurally Defined Chito-Oligosaccharides with a Single N-Acetylation at Their Reducing End Using a Newly Discovered Chitinase from Paenibacillus pabuli. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2021-03-10, 69, 3371-3379.
17. Jia-Tsrong Jan, Ting-Jen Rachel Cheng, Yu-Pu Juang, Hsiu-Hua Ma, Ying-Ta Wu, Wen-Bin Yang, Cheng-Wei Cheng, Xiaorui Chen, Ting-Hung Chou, Jiun-Jie Shie, Wei-Chieh Cheng, Rong-Jie Chein, Shi-Shan Mao, Pi-Hui Liang*, Che Ma*, Shang-Cheng Hung*, Chi-Huey Wong* Identification of Existing Pharmaceuticals and Herbal Medicines as Inhibitors of SARS-CoV-2 Infection. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2021-02-02, 118(5), e2021579118.
18. Yu-Pu Juang, You-Yu Lin, She-Hung Chan, Chun-Kai Chang , Jiun-Jie Shie, Yves SY Hsieh, Jih-Hwa Guh, Pi-Hui Liang* Synthesis, Distribution Analysis and Mechanism Studies of N-Acyl Glucosamine-Bearing Oleanolic Saponins. BIOORGANIC CHEMISTRY 2020-04, 99, 103835.
19. Ching-Han Lee, Han-Wen Chang, Ching-Ting Yang, Niaz Wali, Jiun-Jie Shie, Yen-Ping Hsueh* Sensory Cilia as the Achilles Heel of Nematodes When Attacked by Carnivorous Mushrooms. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2020-03, 117, 6014-6022.
20. Kathleen Joyce D. Carillo, Danni Wu, Su-Ching Lin, Shen-Long Tsai, Jiun-Jie Shie, Der-Lii M. Tzou* 1H/13C Chemical Shifts and Cation Binding Dataset of the Corticosteroid Prednisolone Titrated with Metal Cations. DATA IN BRIEF 2019-12, 27, 104620.
21. Jiun-Jie Shie, Jim-Min Fang* Development of Effective Anti-Influenza Drugs: Congeners and Conjugates – A Review. JOURNAL OF BIOMEDICAL SCIENCE 2019-10, 26, 84.
22. Kathleen D. Carillo, Danni Wu, Su-Ching Lin, Shen-Long Tsai, Jiun-Jie Shie, Der-Lii M.Tzou* Magnesium and Calcium Reveal Different Chelating Effects in a Steroid Compound: A Model Study of Prednisolone Using NMR Spectroscopy. STEROIDS 2019-10, 150, 108429.
23. Danni Wu, Kathleen Joyce D. Carillo, Shen‐Long Tsai, Jiun‐Jie Shie, Der‐Lii M. Tzou* Solid‐State Nuclear Magnetic Resonance Investigation of Neurosteroid Compounds and Magnesium Interactions. JOURNAL OF THE CHINESE CHEMICAL SOCIETY 2019-03, 66, 1318-1326.
24. Pei-Wen Lo, Jiun-Jie Shie, Chein-Hung Chen, Chung-Yi Wu, Tsui-Ling Hsu, Chi-Huey Wong* O-GlcNAcylation Regulates the Stability and Enzymatic Activity of the Histone Methyltransferase EZH2. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2018-07, 115, 7302-7307.
25. Yu-Hin Ho, Sheng-Yang Ho, Cheng-Chih Hsu, Jiun-Jie Shie, Tsung-Shing Andrew Wang* Utilizing An Iron(iii)-Chelation Masking Strategy to Prepare Mono- and Bis-functionalized Aerobactin Analogues for Targeting Pathogenic Bacteria. CHEMICAL COMMUNICATIONS 2017-08, 53, 9265-9268.
26. Vathan Kumar, Jin Soo Shin, Jiun-Jie Shie, Keun Bon Ku, Chonsaeng Kim, Yun Young Go, Kai-Fa Huang, Meehyein Kim*, Po-Huang Liang* Identification and Evaluation of Potent Middle East Respiratory Syndrome Coronavirus (MERS-CoV) 3CLPro Inhibitors. Antiviral Research 2017-03, 141, 101-106.
27. Jiun-Jie Shie*, Ying-Chih Liu, Jye-Chian Hsiao, Jim-Min Fang, Chi-Huey Wong* A Cell-Permeable and Triazole-Forming Fluorescent Probe for Glycoconjugate Imaging in Live Cells . CHEMICAL COMMUNICATIONS 2017-01, 53, 1490-1493.
28. Jiun-Jie Shie, Ying-Chih Liu, Yu-Ming Lee, Carmay Lim, Jim-Min Fang, Chi-Huey Wong* An Azido-BODIPY Probe for Glycosylation: Initiation of Strong Fluorescence upon Triazole Formation. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2014-07, 136, 9953-9961.
29. Chun-Lin Chen, Tzu-Chen Lin, Shi-Yun Wang, Jiun-Jie Shie, Keng-Chang Tsai, Yih-Shyun E. Cheng, Jia-Tsrong Jan, Chun-Jung Lin*, Jim-Min Fang*, Chi-Huey Wong* Tamiphosphor Monoesters as Effective Anti-influenza Agents. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2014-06, 81, 106-118.
30. Chung-Kai Cheng, Chen-Hsuan Tsai, Jiun-Jie Shie, Jim-Min Fang* From Neuraminidase Inhibitors to Conjugates: A Step towards Better Anti-Influenza Drugs. Future Medicinal Chemistry 2014-05, 6, 757-774.
31. Yuan-Siao Chen, Hui-Ming Yu, Jiun-Jie Shie, Ting-Jen Rachel Cheng, Chung-Yi Wu*, Jim-Min Fang*, Chi-Huey Wong* Chemical Constituents of Plectranthus Amboinicus and the Synthetic Analogs Possessing Anti-Inflammatory Activity. BIOORGANIC & MEDICINAL CHEMISTRY 2014-03, 22, 1766-1772.
32. Jiun-Jie Shie, Jim-Min Fang* Phosphonate Congeners of Oseltamivir and Zanamivir as Effective Anti-influenza Drugs: Design, Synthesis and Biological Activity. JOURNAL OF THE CHINESE CHEMICAL SOCIETY 2014-01, 61, 127-141.
33. Ting-Jen R. Cheng, Steven Weinheimer, E. Bart Tarbet, Jia-Tsrong Jan, Yih-Shyun E. Cheng, Jiun-Jie Shie, Chun-Lin Chen, Chih-An Chen, Wei-Che Hsieh, Pei-Wei Huang, Wei-Hao Lin, Shi-Yun Wang, Jim-Min Fang*, Oliver Yoa-Pu Hu*, Chi-Huey Wong* Development of Oseltamivir Phosphonate Congeners as Anti-Influenza Agents. JOURNAL OF MEDICINAL CHEMISTRY 2012-10, 55, 8657-8670.
34. Jiun-Jie Shie, Jim-Min Fang*, Po-Ting Lai, Wen-Hsien Wen, Shi-Yun Wang, Yih-Shyun E. Cheng, Keng-Chang Tsai, An-Suei Yang, Chi-Huey Wong* A Practical Synthesis of Zanamivir Phosphonate Congeners with Potent Anti-Influenza Activity. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2011-11, 133, 17959-17965.
35. Jiun-Jie Shie, Chih-An Chen, Chih-Chien Lin, Angela Fay Ku, Cheng, T.-J. R.; Ting-Jen R. Cheng, Jim-Min Fang*, Chi-Huey Wong* Regioselective Synthesis of Di-C-Glycosylflavones Possessing Anti-Inflammation Activities. ORGANIC & BIOMOLECULAR CHEMISTRY 2010-10, 8, 4451-4462.
36. Chia-Ching Cho, Jia-Nan Liu, Chung-Hsun Chien, Jiun-Jie Shie, Ting-Chu Chen, Jim-Min Fang* Direct Amidation of Aldoses and Decarboxylative Amidation of α-Keto Acids: An Efficient Conjugation Method for Carbohydrate Molecules. JOURNAL OF ORGANIC CHEMISTRY 2009-02, 74, 1549-1556.
37. Ching-Yao Su, Shi-Yun Wang, Jiun-Jie Shie, King-Song Jeng, Nigel J. Temperton, Jim-Min Fang, Chi-Huey Wong, Yih-Shyun E. Cheng* In Vitro Evaluation of Neuraminidase Inhibitors Using the Neuraminidase-Dependent Release Assay of Hemagglutinin-Pseudotyped Viruses. ANTIVIRAL RESEARCH 2008-09, 79, 199-205.
38. Chih-Jung Kuo, Jiun-Jie Shie, Jim-Min Fang*, Guei-Rung Yen, John T.-A. Hsu, Hun-Ge Liu, Sung-Nain Tseng, Shih-Cheng Chang, Ching-Yin Lee, Shin-Ru Shih, Po-Huang Liang* Design, Synthesis, and Evaluation of 3C Protease Inhibitors as Anti-Enterovirus 71 Agents. BIOORGANIC & MEDICINAL CHEMISTRY 2008-08, 16, 7388-7398.
39. Jiun-Jie Shie, Jim-Min Fang*, Chi-Huey Wong A Concise and Flexible Synthesis of the Potent Anti-Influenza Agents Tamiflu and Tamiphosphor. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2008-06, 47, 5788-5791.
40. Jin-Ching Lee, Shin-Ru Shih, Ten-Yuan Chang, Huan-Yi Tseng, Ya-Feng Shih, Kuei-Jung Yen, Wei-Chun Chen, Jiun-Jie Shie, Jim-Min Fang, Po-Huang Liang, Yu-Sheng Chao, John T.-A. Hsu* A Mammalian Cell-Based Reverse Two-Hybrid System for Functional Analysis of 3C Viral Protease of Human Enterovirus 71. ANALYTICAL BIOCHEMISTRY 2008-04, 375, 115-123.
41. 謝俊結, 方俊民* 流感藥物的設計與發展. 化學 2008, 第六十六卷第四期, 頁279-292.
42. Cheng-Chung Lee, Chih-Jung Kuo, Min-Feng Hsu, Po-Huang Liang, Jim-Min Fang, Jiun-Jie Shie, Andrew H.-J. Wang* Structural Basis of Mercury- and Zinc-Conjugated Complexes as SARS-CoV 3C-Like Protease Inhibitors. FEBS LETTERS 2007-11, 581, 5454-5458.
43. Jiun-Jie Shie, Jim-Min Fang*, Shi-Yun Wang, Keng-Chang Tsai, Yih-Shyun E. Cheng, An-Suei Yang, Shih-Chia Hsiao, Ching-Yao Su, Chi-Huey Wong Synthesis of Tamiflu and Its Phosphonate Congeners Possessing Potent Anti-Influenza Activity. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2007-10, 129, 11892-11893.
44. Jiun-Jie Shie, Jim-Min Fang* Microwave-Assisted One-Pot Tandem Reactions for Direct Conversion of Primary Alcohols and Aldehydes to Triazines and Tetrazoles in Aqueous Media. JOURNAL OF ORGANIC CHEMISTRY 2007-04, 72, 3141-3144.
45. Chung-Yi Wu, Ke-Yung King, Chih-Jung Kuo, Jim-Min Fang, Ying-Ta Wu, Ming-Yi Ho, Chung-Lin Liao, Jiun-Jie Shie, Po-Huang Liang, Chi-Huey Wong* Stable Benzotriazole Esters Mechanism-Based Inactivators of the Severe Acute Respiratory Syndrome 3CL Protease. CHEMISTRY & BIOLOGY 2006-03, 13, 261-268.
46. Jiun-Jie Shie, Jim-Min Fang*, Tun-Hsun Kuo, Chih-Jung Kuo, Po-Huang Liang*, Hung-Jyun Huang, Ying-Ta Wu, Jia-Tsrong Jan, Yih-Shyun E. Cheng, Chi-Huey Wong Inhibition of the Severe Acute Respiratory Syndrome 3CL Protease by Peptidomimetic α,β-Unsaturated Esters. BIOORGANIC & MEDICINAL CHEMISTRY 2005-09, 13, 5240-5252.
47. Jiun-Jie Shie, Jim-Min Fang*, Chih-Jung Kuo, Tun-Hsun Kuo, Po-Huang Liang*, Hung-Jyun Huang, Wen-Bin Yang, Chun-Hung Lin, Jiun-Ling Chen, Yin-Ta Wu, Chi-Huey Wong Discovery of Potent Anilide Inhibitors Against the Severe Acute Respiratory Syndrome 3CL Protease. JOURNAL OF MEDICINAL CHEMISTRY 2005-06, 48, 4469-4473.
48. Jiun-Jie Shie, Penny S Workman, William J Evans, Jim-Min Fang* Comparative Study of TmI2, SmI2, and SmI2/HMPA in the Cross-Coupling Reactions of 2-Acetylthiophene and Thiophene-2-carboxylate with Carbonyl Compounds. TETRAHEDRON LETTERS 2004-03, 45, 2703-2707.
49. Ming‐Yi Chen, Jue‐Liang Hsu, Jiun‐Jie Shie, Jim‐Min Fang* Direct Oxidative Amidation of Aldoses by Iodine in Ammonia Water. JOURNAL OF THE CHINESE CHEMICAL SOCIETY 2003-02, 50, 129-133.
50. Jiun-Jie Shie, Jim-Min Fang* Direct Conversion of Aldehydes to Amides, Tetrazoles, and Triazines in Aqueous Media by One-Pot Tandem Reactions . JOURNAL OF ORGANIC CHEMISTRY 2003-02, 68,1158-1160.
51. Shyh-Ming Yang, Jiun-Jie Shie, Jim-Min Fang*, Sandip Kumar Nandy, Hung-Yu Chang, Syn-Hung Lu, Gladys Wang Synthesis of Polysubstituted Benzothiophenes and Sulfur-Containing Polycyclic Aromatic Compounds via Samarium Diiodide Promoted Three-Component Coupling Reactions of Thiophene-2-carboxylate. JOURNAL OF ORGANIC CHEMISTRY 2002-07, 67, 5208-5215.
52. Jiun-Jie Shie, Shyh-Ming Yang, Chao-Tsen Chen, Jim-Min Fang* A Novel Photochromic System of 4,5-Dialkenylthiophenes Constructed by the Samarium Diiodide Promoted Coupling Reactions of Thiophene-2-carboxylate with Aryl Ketones. ORGANIC LETTERS 2002-04, 4, 1099-1102.
53. Adam Shih-Yuan Lee*, Hsiu-Chih Yeh, Jiun-Jie Shie A Novel, Highly Efficient and Selective Desilylating Method for Trialkylsilyl Ethers. TETRAHEDRON LETTERS 1998-07, 39, 5249-5252.

• Zanamivir phosphonate congeners with anti-influenza activity and determining oseltamivir susceptibility of influenza viruses
  USA:US 9874562 2018
• Reactive labelling compounds and their uses thereof
  USA:US 9759726 2017
• Benzocyclooctyne compounds and their uses thereof
  USA:US 9547009 2017
• Synthesis of oseltamivir containing phosphonate congeners with anti-influenza activity
  USA:US 7888337 2011